Mostrar el registro sencillo del ítem

dc.contributor.authorDavidson, Sean M.
dc.contributor.authorArjun, Sapna
dc.contributor.authorBasalay, Maryna V.
dc.contributor.authorBell, Robert M.
dc.contributor.authorBromage, Daniel I.
dc.contributor.authorBotker, Hans Erik
dc.contributor.authorCarr, Richard D.
dc.contributor.authorCunningham, John
dc.contributor.authorGhosh, Arjun K.
dc.contributor.authorHeusch, Gerd
dc.contributor.authorIbáñez, Borja 
dc.contributor.authorKleinbongard, Petra
dc.contributor.authorLecour, Sandrine
dc.contributor.authorMaddock, Helen
dc.contributor.authorOvize, Michel
dc.contributor.authorWalker, Malcolm
dc.contributor.authorWiart, Marlene
dc.contributor.authorYellon, Derek M.
dc.date.accessioned2018-10-26T07:59:24Z
dc.date.available2018-10-26T07:59:24Z
dc.date.issued2018
dc.identifierISI:000447137600001
dc.identifier.citationBasic Res Cardiol. 2018; 113(6):43
dc.identifier.issn0300-8428
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6528
dc.description.abstractDue to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy. Consequently, strategies designed to protect the heart from lethal cell injury have the potential to be applicable across all three pathologies. The investigators meeting at the 10th Hatter Cardiovascular Institute workshop examined the parallels between ST-segment elevation myocardial infarction (STEMI), ischaemic stroke, and other pathologies that cause the loss of cardiomyocytes including cancer therapeutic cardiotoxicity. They examined the prospects for protection by remote ischaemic conditioning (RIC) in each scenario, and evaluated impasses and novel opportunities for cellular protection, with the future landscape for RIC in the clinical setting to be determined by the outcome of the large ERIC-PPCI/CONDI2 study. It was agreed that the way forward must include measures to improve experimental methodologies, such that they better reflect the clinical scenario and to judiciously select combinations of therapies targeting specific pathways of cellular death and injury.
dc.description.sponsorshipNIHR Biomedical Research Council (SD) and the British Heart Foundation PG/18/44/33790, PG/16/85/32471 (SD, DY). German Research Foundation SFB 1116 B08 (GH, PK). This work has been supported by the OPeRa program (ANR-10-IBHU-0004 OPeRa) and completed within the framework of the RHU MARVELOUS (ANR-16-RHUS-0009) (MO).
dc.language.isoeng
dc.publisherSpringer 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAnthracycline cardiotoxicity
dc.subjectCardioprotection
dc.subjectIschaemic stroke
dc.subjectMyocardial ischaemia
dc.subjectNeuroprotection
dc.subjectReperfusion
dc.subjectMITOCHONDRIAL PERMEABILITY TRANSITION
dc.subjectST-SEGMENT ELEVATION
dc.subjectPERCUTANEOUS CORONARY INTERVENTION
dc.subjectRANDOMIZED CONTROLLED-TRIAL
dc.subjectARTERY-BYPASS SURGERY
dc.subjectHEART POSITION PAPER
dc.subjectNO-REFLOW PHENOMENON
dc.subjectREPERFUSION INJURY
dc.subjectWORKING GROUP
dc.subjectCEREBRAL-ISCHEMIA
dc.titleThe 10th Biennial Hatter Cardiovascular Institute workshop: cellular protectionevaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30310998
dc.format.volume113
dc.identifier.doi10.1007/s00395-018-0704-z
dc.contributor.funderBritish Heart Foundation 
dc.contributor.funderDeutsche Forschungsgemeinschaft (Alemania) 
dc.description.peerreviewed
dc.identifier.e-issn1435-1803
dc.relation.publisherversionhttps://doi.org/10.1007/s00395-018-0704-z
dc.identifier.journalBasic Research in Cardiology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.repisalud.institucionCNIC
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional