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dc.contributor.authorKlein, Alison P
dc.contributor.authorWolpin, Brian M
dc.contributor.authorRisch, Harvey A
dc.contributor.authorStolzenberg-Solomon, Rachael Z
dc.contributor.authorMocci, Evelina
dc.contributor.authorZhang, Mingfeng
dc.contributor.authorCanzian, Federico
dc.contributor.authorChilds, Erica J
dc.contributor.authorHoskins, Jason W
dc.contributor.authorJermusyk, Ashley
dc.contributor.authorZhong, Jun
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorWhite, Emily
dc.contributor.authorYu, Herbert
dc.contributor.authorYu, Kai
dc.contributor.authorZheng, Wei
dc.contributor.authorKraft, Peter
dc.contributor.authorLi, Donghui
dc.contributor.authorObazee, Ofure
dc.contributor.authorPetersen, Gloria M
dc.contributor.authorBrais, Lauren
dc.contributor.authorAmundadottir, Laufey T
dc.contributor.authorAndreotti, Gabriella
dc.contributor.authorArslan, Alan A
dc.contributor.authorBuring, Julie
dc.contributor.authorBabic, Ana
dc.contributor.authorBamlet, William R
dc.contributor.authorBeane-Freeman, Laura
dc.contributor.authorChaffee, Kari G
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorBlackford, Amanda
dc.contributor.authorChung, Charles C
dc.contributor.authorBorges, Michael
dc.contributor.authorBorgida, Ayelet
dc.contributor.authorBracci, Paige M
dc.contributor.authorBrennan, Paul
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorCampa, Daniele
dc.contributor.authorCapurso, Gabriele
dc.contributor.authorCavestro, Giulia Martina
dc.contributor.authorCleary, Sean
dc.contributor.authorCotterchio, Michelle
dc.contributor.authorGoodman, Gary E
dc.contributor.authorDijk, Frederike
dc.contributor.authorDuell, Eric J
dc.contributor.authorForetova, Lenka
dc.contributor.authorHartge, Patricia
dc.contributor.authorFuchs, Charles
dc.contributor.authorFunel, Niccola
dc.contributor.authorGallinger, Steven
dc.contributor.authorHerman, Joseph
dc.contributor.authorM Gaziano, J Michael
dc.contributor.authorGazouli, Maria
dc.contributor.authorHolcatova, Ivana
dc.contributor.authorGiles, Graham G
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGoggins, Michael
dc.contributor.authorGoodman, Phyllis J
dc.contributor.authorHackert, Thilo
dc.contributor.authorHaiman, Christopher
dc.contributor.authorHasan, Manal
dc.contributor.authorHegyi, Peter
dc.contributor.authorHelzlsouer, Kathy J
dc.contributor.authorHolly, Elizabeth A
dc.contributor.authorHoover, Robert
dc.contributor.authorKurtz, Robert J
dc.contributor.authorHung, Rayjean J
dc.contributor.authorJacobs, Eric J
dc.contributor.authorJamroziak, Krzysztof
dc.contributor.authorLee, I-Min
dc.contributor.authorJanout, Vladimir
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorMambrini, Andrea
dc.contributor.authorKlein, Eric A
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorMannisto, Satu
dc.contributor.authorKooperberg, Charles
dc.contributor.authorKulke, Matthew H
dc.contributor.authorKupcinskas, Juozas
dc.contributor.authorLaheru, Daniel
dc.contributor.authorLandi, Stefano
dc.contributor.authorLawlor, Rita T
dc.contributor.authorLeMarchand, Loic
dc.contributor.authorLu, Lingeng
dc.contributor.authorMalats, Núria
dc.contributor.authorMilne, Roger L
dc.contributor.authorMohelníková-Duchoňová, Beatrice
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorNeale, Rachel E
dc.contributor.authorNeoptolemos, John P
dc.contributor.authorOberg, Ann L
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorOlson, Sara H
dc.contributor.authorOrlow, Irene
dc.contributor.authorPasquali, Claudio
dc.contributor.authorSund, Malin
dc.contributor.authorPatel, Alpa V
dc.contributor.authorPeters, Ulrike
dc.contributor.authorTalar-Wojnarowska, Renata
dc.contributor.authorPezzilli, Raffaele
dc.contributor.authorPorta, Miquel
dc.contributor.authorReal Arribas, Francisco 
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorSesso, Howard D
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorSilverman, Debra
dc.contributor.authorSmith, Jill P
dc.contributor.authorSoucek, Pavel
dc.contributor.authorTavano, Francesca
dc.contributor.authorThornquist, Mark D
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorTobias, Geoffrey S
dc.contributor.authorVan Den Eeden, Stephen K
dc.contributor.authorVashist, Yogesh
dc.contributor.authorChanock, Stephen
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorVodicka, Pavel
dc.contributor.authorWactawski-Wende, Jean
dc.contributor.authorChen, Fei
dc.contributor.authorWang, Zhaoming
dc.date.accessioned2018-10-25T07:55:15Z
dc.date.available2018-10-25T07:55:15Z
dc.date.issued2018-02-08
dc.identifier.citationNat Commun. 2018; 9(1): 556.es_ES
dc.identifier.issn2041-1723es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6511
dc.description.abstractIn 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.es_ES
dc.description.sponsorshipThis work was supported by RO1 CA154823, the Lustgarten Foundation, and federal funds from the NCI, US NIH under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, and mention of trade names, commercial products, or organizations does not imply endorsement by the US government. Geno-typing Services were provided by the CIDR and the NCIs CGR. CIDR is fully funded through a federal contract from the NIH to the Johns Hopkins University, contract number HHSN268201100011I. The IARC/Central Europe study was supported by a grant from the US NCI at the NIH (R03 CA123546-02) and grants from the Ministry of Health of the Czech Republic (NR 9029-4/2006, NR9422-3, NR9998-3, and MH CZ- DRO-MMCI 00209805). The work at Johns Hopkins University was supported by the NCI Grants P50CA062924 and R01CA97075. Additional support was provided by, Susan Wojcicki, and Dennis Troper, and the Sol Goldman Pancreas Cancer Research Center. The Mayo Clinic Biospecimen Resource for Pancreas Research study is supported by the Mayo Clinic SPORE in Pancreatic Cancer (P50 CA102701). The Memorial Sloan Ket- tering Cancer Center Pancreatic Tumor Registry is supported by P30CA008748, the Geoffrey Beene Foundation, the Arnold and Arlene Goldstein Family, Foundation, and the Society of MSKCC. The PACIFIC Study was supported by RO1CA102765, Kaiser Permanente, and Group Health Cooperative. The Queensland Pancreatic Cancer Study was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC; Grant number 442302). R.E.N. is supported by a NHMRC Senior Research Fellowship (#1060183). The UCSF pancreas study was supported by NIH-NCI grants (R01CA1009767, R01CA109767-S1, and R0CA059706) and the Joan Rombauer Pancreatic Cancer Fund. Collection of cancer incidence data was supported by the California Department of Public Health as part of the statewide cancer reporting pro- gram; the NCIs SEER Program under contract HSN261201000140C awarded to CPIC; and the CDCs National Program of Cancer Registries, under agreement #U58DP003862-01 awarded to the California Department of Public Health. The Yale (CT) pancreas cancer study is supported by NCI at the U.S. NIH, grant 5R01CA098870. The cooperation of 30 Connecticut hospitals, including Stamford Hospital, in allowing patient access is gratefully acknowledged. The Connecticut Pancreas Cancer Study was approved by the State of Connecticut Department of Public Health Human Investigation Committee. Certain data used in that study were obtained from the Connecticut Tumor Registry in the Connecticut Department of Public Health. The authors assume full responsibility for analyses and interpretation of these data. Studies included in PAN- DoRA were partly funded by the Czech Science Foundation (No. P301/12/1734), the Internal Grant Agency of the Czech Ministry of Health (IGA NT 13 263); the Baden- Württemberg State Ministry of Research, Science and Arts (Professor H. Brenner), the Heidelberger EPZ-Pancobank (Professor M.W. Büchler and team: Professor T. Hackert, Dr. N. A. Giese, Dr. Ch. Tjaden, E. Soyka, M. Meinhardt; Heidelberger. Stiftung Chir- urgie and BMBF grant 01GS08114), the BMBH (Professor P. Schirmacher; BMBF grant 01EY1101), the “ 5 × 1000 ” voluntary contribution of the Italian Government, the Italian Ministry of Health (RC1203GA57, RC1303GA53, RC1303GA54, and RC1303GA50), the Italian Association for Research on Cancer (Professor A. Scarpa; AIRC n. 12182), the Italian Ministry of Research (Professor A. Scarpa; FIRB - RBAP10AHJB), the Italian FIMP-Ministry of Health (Professor A. Scarpa; 12 CUP_J33G13000210001), and by the National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, UK. We would like to acknowledge the contribution of Dr. Frederike Dijk and Professor Oliver Busch (Academic Medical Center, Amsterdam, the Netherlands). Assistance with genotype data quality control was provided by Cecelia Laurie and Cathy Laurie at the University of Washington Genetic Analysis Center. The American Cancer Society (ACS) funds the creation, maintenance, and updating of the Cancer Prevention Study II cohort. Cancer incidence data for CLUE were provided by the Maryland Cancer Registry, Center for Cancer Surveillance and Control, Department of Health and Mental Hygiene, 201 W. Preston Street, Room 400, Baltimore, MD 21201, http://phpa.dhmh.maryland.gov/ cancer , 410-767-4055. We acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund, and the National Program of Cancer Registries of the Centers for Disease Control and Prevention for the funds that support the collection and availability of the cancer registry data. We thank all the CLUE participants. The Melbourne Col- laborative Cohort Study (MCCS) recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057 and 396414 and by the infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. The NYU study (AZJ and AAA) was funded by NIH R01 CA098661, UM1 CA182934 and center grants P30 CA016087 and P30 ES000260. The PANKRAS II Study in Spain was supported by research grants from Instituto de Salud Carlos III-FEDER, Spain: Fondo de Investigaciones Sanitarias (FIS; #PI13/00082 and #PI15/01573) and Red Temática de Investigación Cooperativa en Cáncer, Spain (#RD12/ 0036/0050); and European Cooperation in Science and Technology (COST Action #BM1204: EU_Pancreas), Ministerio de Ciencia y Tecnología (CICYT SAF 2000-0097), Fondo de Investigación Sanitaria (95/0017), Madrid, Spain; Generalitat de Catalunya(CIRIT—SGR);“Red temática de investigación cooperativa de centros en Cáncer (C03/10),“Red temática de investigación cooperativa de centros en Epidemiología y salud pública(C03/09), and CIBER de Epidemiología (CIBERESP), Madrid. The Physicians ’Health Study was supported by research grants CA-097193, CA-34944, CA-40360, HL- 26490, and HL-34595 from the NIH, Bethesda, MD, USA. The Womens Health Study was supported by research grants CA-047988, HL-043851, HL-080467, and HL-099355 from the NIH, Bethesda, MD, USA. Health Professionals Follow-up Study is supported by NIH grant UM1 CA167552 from the NCI, Bethesda, MD, USA. Nurses ’ Health Study is supported by NIH grants UM1 CA186107, P01 CA87969, and R01 CA49449 from the NCI, Bethesda, MD, USA. Additional support from the Hale Center for Pancreatic Cancer Research, U01 CA21017 from the NCI, Bethesda, MD, USA, and the United States Department of Defense CA130288, Lustgarten Foundation, Pancreatic Cancer Action Network, Noble Effort Fund, Peter R. Leavitt Family Fund, Wexler Family Fund, and Promises for Purple to B.M. Wolpin is acknowledged. The WHI program is funded by the National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. The authors thank the WHI investigators and staff for their dedication, and the study participants for making the program possible. A full listing of WHI investigators can be found at http://www.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Long%20List.pdf . We thank Laurie Burdett, Aurelie Vogt, BelyndaHicks, Amy Hutchinson, Meredith Yeager, and other staff at the NCI’s Division ofEpidemiology and Genetics (DECG) CGR for GWAS genotyping. We also thank Bao Tran, Jyoti Shetty, and other members of the NCI Center for Cancer Research (CCR) Sequencing Facility for sequencing RNA from histologically normal pancreatic tissue samples (LTG samples). This study utilized the high-performance computational cap- abilities of the Biowulf Linux cluster at the NIH, Bethesda, MD, USA (http://biowulf.nih.gov). The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the NIH, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The data used for the analyses described in this manuscript were obtained from the pancreatic tissue data from the GTEx Portal on 05/04/17. The results published here are in part based upon data generated by The Cancer Genome Atlas (TCGA) managed by the NCI and NHGRI. Information about TCGA can be found at http://cancergenome.nih.gov/. We acknowledge the clinical contributors that provided PDAC samples and the data producers of RNA-seq and GWAS genotype data from TCGA Research Network. The data set used for the analyses described in this manuscript was obtained by formal permission through the TCGA Data Access Committee (DAC)es_ES
dc.language.isoenges_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBODY-MASS INDEXes_ES
dc.subjectASSOCIATION ANALYSESes_ES
dc.subjectGENE-EXPRESSIONes_ES
dc.subjectTRANSCRIPTION FACTORSes_ES
dc.subjectRISKes_ES
dc.subjectIMPUTATIONes_ES
dc.subjectDISEASEes_ES
dc.subjectADENOCARCINOMAes_ES
dc.titleGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic canceres_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29422604es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page556es_ES
dc.identifier.doi10.1038/s41467-018-02942-5es_ES
dc.contributor.funderLung Cancer Research Foundation 
dc.contributor.funderSol Goldman Pancreas Cancer Research Center
dc.contributor.funderGeoffrey Beene Foundation 
dc.contributor.funderArnold and Arlene Goldstein Family Foundation 
dc.contributor.funderNational Health and Medical Research Council (Australia) 
dc.contributor.funderCzech Science Foundation 
dc.contributor.funderJoan Rombauer Pancreatic Cancer Foundation 
dc.contributor.funderNIH - National Cancer Institute (NCI) (Estados Unidos) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Ciencia y Tecnología (España) 
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (RTICC) (España) 
dc.contributor.funderCentro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública) 
dc.description.peerreviewed
dc.identifier.e-issn2041-1723es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41467- 018-02942-5es_ES
dc.identifier.journalNature communicationses_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigaciónes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Carcinogénesis Epiteliales_ES
dc.rights.accessRightsopen accesses_ES


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