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Título
Whole body and hematopoietic ADAM8 deficiency does not influence
advanced atherosclerotic lesion development, despite its association
with human plaque progression
Autor(es)
Theodorou, Kosta | van der Vorst, Emiel P. C. | Gijbels, Marion J. | Wolfs, Ine M. J. | Jeurissen, Mike | Theelen, Thomas L. | Sluimer, Judith C. | Wijnands, Erwin | Cleutjens, Jack P. | Li, Yu | Jansen, Yvonne | Weber, Christian | Ludwig, Andreas | Bentzon, Jacob F CNIC | Bartsch, Joerg W. | Biessen, Erik A. L. | Donners, Marjo M. P. C.
Fecha de publicación
2017
Cita
Sci Rep. 2017; 7(1):11670
Idioma
Inglés
Tipo de documento
journal article
Resumen
Although A Disintegrin And Metalloproteinase 8 (ADAM8) is not crucial
for tissue development and homeostasis, it has been implicated in
various inflammatory diseases by regulating processes like immune cell
recruitment and activation. ADAM8 expression has been associated with
human atherosclerosis development and myocardial infarction, however a
causal role of ADAM8 in atherosclerosis has not been investigated thus
far. In this study, we examined the expression of ADAM8 in early and
progressed human atherosclerotic lesions, in which ADAM8 was
significantly upregulated in vulnerable lesions. In addition, ADAM8
expression was most prominent in the shoulder region of human
atherosclerotic lesions, characterized by the abundance of foam cells.
In mice, Adam8 was highly expressed in circulating neutrophils and in
macrophages. Moreover, ADAM8 deficient mouse macrophages displayed
reduced secretion of inflammatory mediators. Remarkably, however,
neither hematopoietic nor whole-body ADAM8 deficiency in mice affected
atherosclerotic lesion size. Additionally, except for an increase in
granulocyte content in plaques of ADAM8 deficient mice, lesion
morphology was unaffected. Taken together, whole body and hematopoietic
ADAM8 does not contribute to advanced atherosclerotic plaque
development, at least in female mice, although its expression might
still be valuable as a diagnostic/ prognostic biomarker to distinguish
between stable and unstable lesions.
Palabras clave
METALLOPROTEASE-DISINTEGRIN ADAM8 | TUMOR-NECROSIS-FACTOR | MYOCARDIAL-INFARCTION | TNF-ALPHA | EXPRESSION ANALYSIS | PERIPHERAL-BLOOD | DENDRITIC CELLS | TRANSGENIC MICE | IMMUNE-SYSTEM | MACROPHAGES
Versión en línea
DOI
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