Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5773
Vpu Protein: The Viroporin Encoded by HIV-1
Gonzalez, Maria Eugenia ISCIII
Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compartments result in pleiotropic effects in host cells. Notwithstanding the high variability of its amino acid sequence, the functionality of Vpu is well conserved in pandemic virus isolates. This review outlines our current knowledge on the interactions of Vpu with the host cell. The regulation of cellular physiology by Vpu and the validity of this viroporin as a therapeutic target are also discussed.
HIV-1 | Viroporin | Vpu | antiretroviral target | ion transport | membrane permeability | membrane pore | protein trafficking
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