Mostrar el registro sencillo del ítem

dc.contributor.authorNuñez, Olivier 
dc.contributor.authorFernandez-Navarro, Pablo L 
dc.contributor.authorMartín-Méndez, Iván
dc.contributor.authorBel-Lan, Alejandro
dc.contributor.authorLocutura Rupérez, Juan F
dc.contributor.authorLopez-Abente, Gonzalo 
dc.date.accessioned2018-03-21T07:57:32Z
dc.date.available2018-03-21T07:57:32Z
dc.date.issued2017-01-20
dc.identifier.citationEnviron Sci Pollut Res Int. 2017; 24(8): 7413–7421.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5772
dc.descriptionErratum to: Association between heavy metal and metalloid levels in topsoil and cancer mortality in Spain. Environ Sci Pollut Res Int. 2017 Mar;24(8):7422. doi: 10.1007/s11356-017-8507-6. PMID: 28164247.
dc.description.abstractSpatio-temporal cancer mortality studies in Spain have revealed patterns for some tumours which display a distribution that is similar across the sexes and persists over time. Such characteristics would be common to tumours that shared risk factors, including the geochemical composition of the soil. The aim of this study was to assess the possible association between heavy metal and metalloid levels in topsoil (upper soil horizon) and cancer mortality in mainland Spain. Ecological cancer mortality study at a municipal level, covering 861,440 cancer deaths (27 different tumour locations) in 7917 Spanish mainland towns, from 1999 to 2008. The elements included in this analysis were Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn. Topsoil levels (partial extraction) were determined by ICP-MS at 13,317 sampling points. For the analysis, the data on the topsoil composition have been transformed by the centred logratio (clr-transformation). Principal factor analysis was performed to obtain independent latent factors for the transformed variables. To estimate the effect of heavy metal levels in topsoil composition on mortality, we fitted Besag, York and Mollié models, which included each town's factor scores as the explanatory variable. Integrated Nested Laplace Approximation (INLA) was used as a tool for Bayesian inference. All results were adjusted for sociodemographic variables. The results showed an association between trace contents of heavy metals and metalloids in topsoil and mortality due to tumours of the digestive system in mainland Spain. This association was observed in both sexes, something that would support the hypothesis that the incorporation of heavy metals into the trophic chain might be playing a role in the aetiology of some types of cancer. Topsoil composition and the presence of potentially toxic elements in trace concentrations might be an additional component in the aetiology of some types of cancer, and go some way to determine the ensuing geographic differences in mortality in Spain. The results support the interest of inclusion of heavy metal levels in topsoil as a hypothesis in analytical epidemiological studies using biological markers of exposure to heavy metals and metalloids.es_ES
dc.description.sponsorshipThe study was partially supported by research grants from the Carlos III Institute of Health (PI4CIII/50) and Spanish Health Research Fund (FIS PI11/00871 and FIS CP11/00112). Mortality data were supplied by the Spanish National Statistics Institute in accordance with a specific confidentiality protocol.es_ES
dc.language.isoenges_ES
dc.publisherSpringer es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCancer mortalityes_ES
dc.subjectCompositional analysises_ES
dc.subjectGeochemistryes_ES
dc.subjectMedical geologyes_ES
dc.subjectSoil compositiones_ES
dc.subjectSpatial data analysises_ES
dc.titleAssociation between heavy metal and metalloid levels in topsoil and cancer mortality in Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID28108922es_ES
dc.format.volume24es_ES
dc.format.number8es_ES
dc.format.page7413-7421es_ES
dc.identifier.doi10.1007/s11356-017-8418-6es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1614-7499es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s1135es_ES
dc.identifier.journalEnvironmental science and pollution research internationales_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2011) (2011)/PI11/00871
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CP11/00112
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI4CIII/50


Ficheros en el ítem

Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional