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dc.contributor.authorPlaza Menacho, Ivan 
dc.date.accessioned2018-03-09T11:13:28Z
dc.date.available2018-03-09T11:13:28Z
dc.date.issued2018-02
dc.identifier.citationEndocr Relat Cancer.2018; 25 (2): T79-T90.es_ES
dc.identifier.issn1351-0088es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5719
dc.description.abstractIt has been twenty-five years since the discovery of oncogenic germline RET mutations as the cause of multiple endocrine neoplasia type 2 (MEN2). Intensive work over the last two and a half decades on RET genetics, signaling and cell biology has provided the current bases for the genotype-phenotype and functional correlations within this cancer syndrome. On the contrary, the structural and molecular basis for RET tyrosine kinase domain activation and oncogenic deregulation has remained largely elusive. Recent studies with a strong crystallographic and biochemical focus have started to elucidate key insights into such molecular and atomic details revealing unexpected and private mechanisms of actions and molecular determinants not previously envisioned. This review focuses on the structure and function of the RET receptor, and in particular, on what a more detailed view of the protein itself and what the current structural and molecular information tell us about the genotype and phenotype relationships in the cancer syndrome MEN2.es_ES
dc.language.isoenges_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectanti-cancer therapyes_ES
dc.subjectoncogene signalinges_ES
dc.subjectprotein kinasees_ES
dc.subjectstructure-functiones_ES
dc.titleStructure and function of RET in multiple endocrine neoplasia type 2es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID29175871es_ES
dc.format.volume25es_ES
dc.format.number2es_ES
dc.format.pageT79-T90es_ES
dc.identifier.doi10.1530/ERC-17-0354es_ES
dc.description.peerreviewed
dc.identifier.e-issn1479-6821es_ES
dc.relation.publisherversionhttp://erc.endocrinology-journals.org/content/25/2/T79.long
dc.identifier.journalEndocrine-related canceres_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigaciónes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional