Mostrar el registro sencillo del ítem

dc.contributor.authorFernandez-Jimenez, Rodrigo 
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorAguero, Jaume 
dc.contributor.authorGarcia-Prieto, Jaime 
dc.contributor.authorLopez-Martin, Gonzalo J. 
dc.contributor.authorGarcia-Ruiz, Jose M 
dc.contributor.authorMolina-Iracheta, Antonio 
dc.contributor.authorRossello, Xavier 
dc.contributor.authorFernandez-Friera, Leticia 
dc.contributor.authorPizarro, Gonzalo 
dc.contributor.authorGarcia-Alvarez, Ana 
dc.contributor.authorDall'Armellina, Erica
dc.contributor.authorMacaya, Carlos
dc.contributor.authorChoudhury, Robin P
dc.contributor.authorFuster, Valentin 
dc.contributor.authorIbáñez, Borja 
dc.date.accessioned2017-12-01T07:37:25Z
dc.date.available2017-12-01T07:37:25Z
dc.date.issued2015
dc.identifierISI:000348666800001
dc.identifier.citationJ Am Coll Cardiol. 2015 Feb 3;65(4):315-323
dc.identifier.issn0735-1097
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5518
dc.description.abstractBACKGROUND It is widely accepted that edema occurs early in the ischemic zone and persists in stable form for at least 1 week after myocardial ischemia/reperfusion. However, there are no longitudinal studies covering from very early (minutes) to late (1 week) reperfusion stages confirming this phenomenon. OBJECTIVES This study sought to perform a comprehensive longitudinal imaging and histological characterization of the edematous reaction after experimental myocardial ischemia/reperfusion. METHODS The study population consisted of 25 instrumented Large-White pigs (30 kg to 40 kg). Closed-chest 40-min ischemia/reperfusion was performed in 20 pigs, which were sacrificed at 120 min (n = 5), 24 h (n = 5), 4 days (n = 5), and 7 days (n = 5) after reperfusion and processed for histological quantification of myocardial water content. Cardiac magnetic resonance (CMR) scans with T2-weighted short-tau inversion recovery and T2-mapping sequences were performed at every follow-up stage until sacrifice. Five additional pigs sacrificed after baseline CMR served as controls. RESULTS In all pigs, reperfusion was associated with a significant increase in T2 relaxation times in the ischemic region. On 24-h CMR, ischemic myocardium T2 times returned to normal values (similar to those seen pre-infarction). Thereafter, ischemic myocardium-T2 times in CMR performed on days 4 and 7 after reperfusion progressively and systematically increased. On day 7 CMR, T2 relaxation times were as high as those observed at reperfusion. Myocardial water content analysis in the ischemic region showed a parallel bimodal pattern: 2 high water content peaks at reperfusion and at day 7, and a significant decrease at 24 h. CONCLUSIONS Contrary to the accepted view, myocardial edema during the first week after ischemia/reperfusion follows a bimodal pattern. The initial wave appears abruptly upon reperfusion and dissipates at 24 h. Conversely, the deferred wave of edema appears progressively days after ischemia/reperfusion and is maximal around day 7 after reperfusion. (C) 2015 by the American College of Cardiology Foundation.
dc.language.isoeng
dc.publisherElsevier 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCMR
dc.subjectMRI
dc.subjectMyocardial infarction
dc.subjectpig
dc.subjectT2
dc.subjectWater content
dc.subjectCARDIAC MAGNETIC-RESONANCE
dc.subjectPERCUTANEOUS CORONARY INTERVENTION
dc.subjectINFARCT SIZE
dc.subjectREPERFUSION INJURY
dc.subjectTRANSIENT PERIOD
dc.subjectRISK
dc.subjectAREA
dc.subjectISCHEMIA
dc.subjectCONTRAST
dc.titleMyocardial Edema After Ischemia/Reperfusion Is Not Stable and Follows a Bimodal Pattern Imaging and Histological Tissue Characterization
dc.typejournal article
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID25460833
dc.format.volume65
dc.format.page315-323
dc.identifier.doi10.1016/j.jacc.2014.11.004
dc.contributor.funderBritish Heart Foundation 
dc.contributor.funderWellcome Trust 
dc.description.peerreviewed
dc.identifier.e-issn1558-3597
dc.identifier.journalJournal of the American College of Cardiology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales
dc.repisalud.institucionCNIC
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional