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dc.contributor.author | Fernandez-Jimenez, Rodrigo | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Aguero, Jaume | |
dc.contributor.author | Garcia-Prieto, Jaime | |
dc.contributor.author | Lopez-Martin, Gonzalo J. | |
dc.contributor.author | Garcia-Ruiz, Jose M | |
dc.contributor.author | Molina-Iracheta, Antonio | |
dc.contributor.author | Rossello, Xavier | |
dc.contributor.author | Fernandez-Friera, Leticia | |
dc.contributor.author | Pizarro, Gonzalo | |
dc.contributor.author | Garcia-Alvarez, Ana | |
dc.contributor.author | Dall'Armellina, Erica | |
dc.contributor.author | Macaya, Carlos | |
dc.contributor.author | Choudhury, Robin P | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Ibáñez, Borja | |
dc.date.accessioned | 2017-12-01T07:37:25Z | |
dc.date.available | 2017-12-01T07:37:25Z | |
dc.date.issued | 2015 | |
dc.identifier | ISI:000348666800001 | |
dc.identifier.citation | J Am Coll Cardiol. 2015 Feb 3;65(4):315-323 | |
dc.identifier.issn | 0735-1097 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5518 | |
dc.description.abstract | BACKGROUND It is widely accepted that edema occurs early in the ischemic zone and persists in stable form for at least 1 week after myocardial ischemia/reperfusion. However, there are no longitudinal studies covering from very early (minutes) to late (1 week) reperfusion stages confirming this phenomenon. OBJECTIVES This study sought to perform a comprehensive longitudinal imaging and histological characterization of the edematous reaction after experimental myocardial ischemia/reperfusion. METHODS The study population consisted of 25 instrumented Large-White pigs (30 kg to 40 kg). Closed-chest 40-min ischemia/reperfusion was performed in 20 pigs, which were sacrificed at 120 min (n = 5), 24 h (n = 5), 4 days (n = 5), and 7 days (n = 5) after reperfusion and processed for histological quantification of myocardial water content. Cardiac magnetic resonance (CMR) scans with T2-weighted short-tau inversion recovery and T2-mapping sequences were performed at every follow-up stage until sacrifice. Five additional pigs sacrificed after baseline CMR served as controls. RESULTS In all pigs, reperfusion was associated with a significant increase in T2 relaxation times in the ischemic region. On 24-h CMR, ischemic myocardium T2 times returned to normal values (similar to those seen pre-infarction). Thereafter, ischemic myocardium-T2 times in CMR performed on days 4 and 7 after reperfusion progressively and systematically increased. On day 7 CMR, T2 relaxation times were as high as those observed at reperfusion. Myocardial water content analysis in the ischemic region showed a parallel bimodal pattern: 2 high water content peaks at reperfusion and at day 7, and a significant decrease at 24 h. CONCLUSIONS Contrary to the accepted view, myocardial edema during the first week after ischemia/reperfusion follows a bimodal pattern. The initial wave appears abruptly upon reperfusion and dissipates at 24 h. Conversely, the deferred wave of edema appears progressively days after ischemia/reperfusion and is maximal around day 7 after reperfusion. (C) 2015 by the American College of Cardiology Foundation. | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | CMR | |
dc.subject | MRI | |
dc.subject | Myocardial infarction | |
dc.subject | pig | |
dc.subject | T2 | |
dc.subject | Water content | |
dc.subject | CARDIAC MAGNETIC-RESONANCE | |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | |
dc.subject | INFARCT SIZE | |
dc.subject | REPERFUSION INJURY | |
dc.subject | TRANSIENT PERIOD | |
dc.subject | RISK | |
dc.subject | AREA | |
dc.subject | ISCHEMIA | |
dc.subject | CONTRAST | |
dc.title | Myocardial Edema After Ischemia/Reperfusion Is Not Stable and Follows a Bimodal Pattern Imaging and Histological Tissue Characterization | |
dc.type | journal article | |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 25460833 | |
dc.format.volume | 65 | |
dc.format.page | 315-323 | |
dc.identifier.doi | 10.1016/j.jacc.2014.11.004 | |
dc.contributor.funder | British Heart Foundation | |
dc.contributor.funder | Wellcome Trust | |
dc.description.peerreviewed | Sí | |
dc.identifier.e-issn | 1558-3597 | |
dc.identifier.journal | Journal of the American College of Cardiology | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | |
dc.repisalud.institucion | CNIC | |
dc.rights.accessRights | open access | es_ES |