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dc.contributor.authorLaclaustra, Martin 
dc.contributor.authorVan den Berg, Elizabeth Louise Maayken
dc.contributor.authorHurtado-Roca, Yamilee 
dc.contributor.authorManuel Castellote, Juan
dc.date.accessioned2017-12-01T07:37:25Z
dc.date.available2017-12-01T07:37:25Z
dc.date.issued2015
dc.identifierISI:000350662100014
dc.identifier.citationPLoS One. 2015; 10(2):e0115522
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5514
dc.description.abstractBackground and Aims Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study). Materials and Methods A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex. Results Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p < 0.05). No association was found between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides in SCI subjects were lower than in sex- and age-stratified values from the reference sample. Conclusion A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.
dc.description.sponsorshipDr. Laclaustra was supported in part by grants FIS CP08/00112 and PI10/00021 from the Spanish Instituto de Salud Carlos III. Dr. Castellote was supported in part by grants TPY 1115/07, PI13/00526, TPY 1444/08 and ESVI 1338/12-1 from the Instituto de Salud Carlos III. Dr. Hurtado was supported by Fellowship N degrees 088-FINCyT-BDE-2014 from the Peruvian government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCARDIOVASCULAR-DISEASE RISK
dc.subjectSYMPATHETIC-NERVOUS-SYSTEM
dc.subjectRESTING METABOLIC-RATE
dc.subjectADIPOSE-TISSUE
dc.subjectHEART-DISEASE
dc.subjectPARAPLEGIA
dc.subjectEXERCISE
dc.subjectPARTICIPATION
dc.subjectCATECHOLAMINES
dc.subjectINDIVIDUALS
dc.titleSerum Lipid Profile in Subjects with Traumatic Spinal Cord Injury
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.format.volume10
dc.identifier.doi10.1371/journal.pone.0115522
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderGobierno de Perú
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0115522
dc.identifier.journalPlos One
dc.repisalud.orgCNICCNIC::Grupos de investigación::Antiguos CNIC
dc.repisalud.institucionCNIC
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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