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dc.contributor.author | Fernandez-Jimenez, Rodrigo | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Aguero, Jaume | |
dc.contributor.author | del Trigo, Maria | |
dc.contributor.author | Galan-Arriola, Carlos | |
dc.contributor.author | Fuster, Valentin | |
dc.contributor.author | Ibáñez, Borja | |
dc.date.accessioned | 2017-10-30T13:32:28Z | |
dc.date.available | 2017-10-30T13:32:28Z | |
dc.date.issued | 2015 | |
dc.identifier | ISI:000364018500001 | |
dc.identifier.citation | J Cardiovasc Magn Reson. 2015; 17(1):92 | |
dc.identifier.issn | 1097-6647 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5258 | |
dc.description.abstract | Background: Several T2-mapping sequences have been recently proposed to quantify myocardial edema by providing T2 relaxation time values. However, no T2-mapping sequence has ever been validated against actual myocardial water content for edema detection. In addition, these T2-mapping sequences are either time-consuming or require specialized software for data acquisition and/or post-processing, factors impeding their routine clinical use. Our objective was to obtain in vivo validation of a sequence for fast and accurate myocardial T2-mapping (T2 gradient-spin-echo [GraSE]) that can be easily integrated in routine protocols. Methods: The study population comprised 25 pigs. Closed-chest 40 min ischemia/reperfusion was performed in 20 pigs. Pigs were sacrificed at 120 min (n = 5), 24 h (n = 5), 4 days (n = 5) and 7 days (n = 5) after reperfusion, and heart tissue extracted for quantification of myocardial water content. For the evaluation of T2 relaxation time, cardiovascular magnetic resonance (CMR) scans, including T2 turbo-spin-echo (T2-TSE, reference standard) mapping and T2-GraSE mapping, were performed at baseline and at every follow-up until sacrifice. Five additional pigs were sacrificed after baseline CMR study and served as controls. Results: Acquisition of T2-GraSE mapping was significantly (3-fold) faster than conventional T2-TSE mapping. Myocardial T2 relaxation measurements performed by T2-TSE and T2-GraSE mapping demonstrated an almost perfect correlation (R-2 = 0.99) and agreement with no systematic error between techniques. The two T2-mapping sequences showed similarly good correlations with myocardial water content: R-2 = 0.75 and R-2 = 0.73 for T2-TSE and T2-GraSE mapping, respectively. Conclusions: We present the first in vivo validation of T2-mapping to assess myocardial edema. Given its shorter acquisition time and no requirement for specific software for data acquisition or post-processing, fast T2-GraSE mapping of the myocardium offers an attractive alternative to current CMR sequences for T2 quantification. | |
dc.description.sponsorship | This work was supported by a competitive grant from the Ministry of Economy and Competitiveness (MINECO) through the Carlos III Institute of Health -Fondo de Investigacion Sanitaria (PI13/01979)-, the Fondo Europeo de Desarrollo Regional (FEDER, RD: SAF2013-49663-EXP), and in part by the FP7-PEOPLE-2013-ITN Next generation training in cardiovascular research and innovation-Cardionext. Rodrigo Fernandez-Jimenez is recipient of a Rio Hortega fellowship from the Ministry of Economy and Competitiveness through the Instituto de Salud Carlos III, and a FICNIC fellowship from the Fundacio Jesus Serra, the Fundacion Interhospitalaria de Investigacion Cardiovascular (FIC) and the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC). Javier Sanchez-Gonzalez is an employee of Philips Healthcare. Jaume Aguero is a FP7-PEOPLE-2013-ITN-Cardionext fellow. Carlos Galan-Arriola is recipient of a ``Contrato Predoctoral de Formacion en Investigacion en Salud (PFIS), FI14/00356´´. This study forms part of a Master Research Agreement (MRA) between CNIC and Philips Healthcare. Borja Ibanez is supported by the Red de Investigacion Cardiovascular (RIC) of the Spanish Ministry of Health (RD 12/0042/0054). The CNIC is supported by the Spanish Ministry of Economy and Competitiveness and the Pro-CNIC Foundation. | |
dc.language.iso | eng | |
dc.publisher | BioMed Central (BMC) | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cardiovascular magnetic resonance | |
dc.subject | T2-mapping | |
dc.subject | Imaging | |
dc.subject | Myocardial infarction | |
dc.subject | Edema | |
dc.subject | Water content | |
dc.subject | CARDIAC MAGNETIC-RESONANCE | |
dc.subject | TISSUE CHARACTERIZATION | |
dc.subject | RELAXATION-TIMES | |
dc.subject | INFARCTION | |
dc.subject | RISK | |
dc.subject | INJURY | |
dc.subject | AREA | |
dc.subject | CMR | |
dc.subject | CONTROVERSIES | |
dc.subject | REPERFUSION | |
dc.title | Fast T2 gradient-spin-echo (T2-GraSE) mapping for myocardial edema quantification: first in vivo validation in a porcine model of ischemia/reperfusion | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 26538198 | |
dc.format.volume | 17 | |
dc.identifier.doi | 10.1186/s12968-015-0199-9 | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Fundación Jesús Serra | |
dc.contributor.funder | Fundación Interhospitalaria de Investigación Cardiovascular | |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | |
dc.identifier.e-issn | 1532-429X | |
dc.relation.publisherversion | https://doi.org/10.1136/10.1186/s12968-015-0199-9 | |
dc.identifier.journal | Journal of Cardiovascular Magnetic Resonance | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | MINECO/ICTI2013-2016/SAF2013-49663-EXP | es_ES |
dc.rights.accessRights | open access | es_ES |