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dc.contributor.author | Rodius, Sophie | |
dc.contributor.author | Androsova, Ganna | |
dc.contributor.author | Gotz, Lou | |
dc.contributor.author | Liechti, Robin | |
dc.contributor.author | Crespo, Isaac | |
dc.contributor.author | Merz, Susanne | |
dc.contributor.author | Nazarov, Petr V. | |
dc.contributor.author | de Klein, Niek | |
dc.contributor.author | Jeanty, Celine | |
dc.contributor.author | Gonzalez-Rosa, Juan M. | |
dc.contributor.author | Muller, Arnaud | |
dc.contributor.author | Bernardin, Francois | |
dc.contributor.author | Niclou, Simone P. | |
dc.contributor.author | Vallar, Laurent | |
dc.contributor.author | Mercader, Nadia | |
dc.contributor.author | Ibberson, Mark | |
dc.contributor.author | Xenarios, Ioannis | |
dc.contributor.author | Azuaje, Francisco | |
dc.date.accessioned | 2017-10-30T13:15:45Z | |
dc.date.available | 2017-10-30T13:15:45Z | |
dc.date.issued | 2016 | |
dc.identifier | ISI:000376877100001 | |
dc.identifier.citation | Sci Rep. 2016; 6:26822 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5228 | |
dc.description.abstract | The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration. | |
dc.description.sponsorship | We thank C. Hoffmann and J. Esposito for technical support, A. Feenstra (VUA) for co-supervision of N.K., and R. Schneider (LCSB) for co-supervision of G.A. during her work at LIH and current support at LCSB. This research was funded by Luxembourg's National Research Fund (FNR) and the Swiss National Research Foundation (SNF), INFUSED project (www.infused-project.eu). N.M. was supported by Comunidad de Madrid (Fibroteam P2010/BMD-2321) and the ERC (Starting Grant 2013 337703 zebraHeart). Zebrafish drawing in Figure 1 was adapted from Wikimedia Commons (http://bit.ly/1PL92vj). | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | MYOCARDIAL-INFARCTION | |
dc.subject | GENE-EXPRESSION | |
dc.subject | CARDIAC REGENERATION | |
dc.subject | EPICARDIAL CELLS | |
dc.subject | INJURY | |
dc.subject | CARDIOMYOCYTES | |
dc.subject | MODEL | |
dc.subject | CRYOINJURY | |
dc.subject | TARGET | |
dc.subject | DIFFERENTIATION | |
dc.title | Analysis of the dynamic co-expression network of heart regeneration in the zebrafish | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 27241320 | |
dc.format.volume | 6 | |
dc.identifier.doi | 10.1038/srep26822 | |
dc.contributor.funder | Luxembourg National Research Fund | |
dc.contributor.funder | Swiss National Research Foundation | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1038/srep26822 | |
dc.identifier.journal | Scientific Reports | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Desarrollo del Epicardio y su Papel en la Regeneración | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/337703 | es_ES |
dc.rights.accessRights | open access | es_ES |