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dc.contributor.authorRodius, Sophie
dc.contributor.authorAndrosova, Ganna
dc.contributor.authorGotz, Lou
dc.contributor.authorLiechti, Robin
dc.contributor.authorCrespo, Isaac 
dc.contributor.authorMerz, Susanne
dc.contributor.authorNazarov, Petr V.
dc.contributor.authorde Klein, Niek
dc.contributor.authorJeanty, Celine
dc.contributor.authorGonzalez-Rosa, Juan M.
dc.contributor.authorMuller, Arnaud
dc.contributor.authorBernardin, Francois
dc.contributor.authorNiclou, Simone P.
dc.contributor.authorVallar, Laurent
dc.contributor.authorMercader, Nadia 
dc.contributor.authorIbberson, Mark
dc.contributor.authorXenarios, Ioannis
dc.contributor.authorAzuaje, Francisco
dc.date.accessioned2017-10-30T13:15:45Z
dc.date.available2017-10-30T13:15:45Z
dc.date.issued2016
dc.identifierISI:000376877100001
dc.identifier.citationSci Rep. 2016; 6:26822
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5228
dc.description.abstractThe zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration.
dc.description.sponsorshipWe thank C. Hoffmann and J. Esposito for technical support, A. Feenstra (VUA) for co-supervision of N.K., and R. Schneider (LCSB) for co-supervision of G.A. during her work at LIH and current support at LCSB. This research was funded by Luxembourg's National Research Fund (FNR) and the Swiss National Research Foundation (SNF), INFUSED project (www.infused-project.eu). N.M. was supported by Comunidad de Madrid (Fibroteam P2010/BMD-2321) and the ERC (Starting Grant 2013 337703 zebraHeart). Zebrafish drawing in Figure 1 was adapted from Wikimedia Commons (http://bit.ly/1PL92vj).
dc.language.isoeng
dc.publisherNature Publishing Group 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMYOCARDIAL-INFARCTION
dc.subjectGENE-EXPRESSION
dc.subjectCARDIAC REGENERATION
dc.subjectEPICARDIAL CELLS
dc.subjectINJURY
dc.subjectCARDIOMYOCYTES
dc.subjectMODEL
dc.subjectCRYOINJURY
dc.subjectTARGET
dc.subjectDIFFERENTIATION
dc.titleAnalysis of the dynamic co-expression network of heart regeneration in the zebrafish
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27241320
dc.format.volume6
dc.identifier.doi10.1038/srep26822
dc.contributor.funderLuxembourg National Research Fund
dc.contributor.funderSwiss National Research Foundation
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC) 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1038/srep26822
dc.identifier.journalScientific Reports
dc.repisalud.orgCNICCNIC::Grupos de investigación::Desarrollo del Epicardio y su Papel en la Regeneración
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/337703es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional