Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5227
Título
Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy
Autor(es)
Fecha de publicación
2016
Cita
Nat Commun. 2016; 7:11838
Idioma
Inglés
Tipo de documento
journal article
Resumen
The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitative positron emission tomography (PET) nanoreporter technology that is predictive of therapeutic outcome in individual subjects. In a breast cancer mouse model, we demonstrate that co-injecting Doxil and a Zirconium-89 nanoreporter (Zr-89-NRep) allows precise doxorubicin (DOX) quantification. Importantly, Zr-89-NRep uptake also correlates with other types of nanoparticles' tumour accumulation. Zr-89-NRep PET imaging reveals remarkable accumulation heterogeneity independent of tumour size. We subsequently demonstrate that mice with 425 mg kg(-1) DOX accumulation in tumours had significantly better growth inhibition and enhanced survival. This non-invasive imaging tool may be developed into a robust inclusion criterion for patients amenable to nanotherapy.
Palabras clave
PEGYLATED LIPOSOMAL DOXORUBICIN | METASTATIC BREAST-CANCER | NAB-PACLITAXEL | OVARIAN-CANCER | DRUG-DELIVERY | TUMOR | NANOMEDICINES | MANAGEMENT | ONCOLOGY | IMPACT
Versión en línea
DOI
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