Show simple item record

dc.contributor.authorBell, R. M.
dc.contributor.authorBotker, H. E.
dc.contributor.authorCarr, R. D.
dc.contributor.authorDavidson, S. M.
dc.contributor.authorDowney, J. M.
dc.contributor.authorDutka, D. P.
dc.contributor.authorHeusch, G.
dc.contributor.authorIbanez, Borja 
dc.contributor.authorMacallister, R.
dc.contributor.authorStoppe, C.
dc.contributor.authorOvize, M.
dc.contributor.authorRedington, A.
dc.contributor.authorWalker, J. M.
dc.contributor.authorYellon, D. M.
dc.date.accessioned2017-10-30T13:15:41Z
dc.date.available2017-10-30T13:15:41Z
dc.date.issued2016
dc.identifierISI:000380111100004
dc.identifier.citationBasic Res Cardiol. 2016; 111(4):41
dc.identifier.issn0300-8428
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5214
dc.description.abstractIn the 30 years since the original description of ischaemic preconditioning, understanding of the pathophysiology of ischaemia/reperfusion injury and concepts of cardioprotection have been revolutionised. In the same period of time, management of patients with coronary artery disease has also been transformed: coronary artery and valve surgery are now deemed routine with generally excellent outcomes, and the management of acute coronary syndromes has seen decade on decade reductions in cardiovascular mortality. Nonetheless, despite these improvements, cardiovascular disease and ischaemic heart disease in particular, remain the leading cause of death and a significant cause of long-term morbidity (with a concomitant increase in the incidence of heart failure) worldwide. The need for effective cardioprotective strategies has never been so pressing. However, despite unequivocal evidence of the existence of ischaemia/reperfusion in animal models providing a robust rationale for study in man, recent phase 3 clinical trials studying a variety of cardioprotective strategies in cardiac surgery and acute ST-elevation myocardial infarction have provided mixed results. The investigators meeting at the Hatter Cardiovascular Institute workshop describe the challenge of translating strong pre-clinical data into effective clinical intervention strategies in patients in whom effective medical therapy is already altering the pathophysiology of ischaemia/reperfusion injury-and lay out a clearly defined framework for future basic and clinical research to improve the chances of successful translation of strong pre-clinical interventions in man.
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERG
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectIschaemia
dc.subjectReperfusion
dc.subjectInjury
dc.subjectInfarction
dc.subjectPre-clinical
dc.subjectBasic research
dc.subjectClinical trials
dc.subjectIschaemic
dc.subjectPreconditioning
dc.subjectPostconditioning
dc.subjectConditioning
dc.subjectRISK pathway
dc.subjectSAFE pathway
dc.subjectp2y12
dc.subjectOpiates
dc.subjectAsprin
dc.subjectBeta blockers
dc.subjectStatins
dc.subjectMetoprolol
dc.subjectCyclosporine
dc.subjectCABG
dc.subjectValve replacement
dc.subjectCardiac surgery
dc.subjectMitochondrial transition pore
dc.subjectNecrosis
dc.subjectApoptosis
dc.subjectNecroptosis
dc.subjectAutophagy
dc.subjectPyroptosis
dc.subjectDNA
dc.subjectACUTE MYOCARDIAL-INFARCTION
dc.subjectPERCUTANEOUS CORONARY INTERVENTION
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectMITOCHONDRIAL PERMEABILITY TRANSITION
dc.subjectBYPASS GRAFT-SURGERY
dc.subjectCYCLOSPORINE-A
dc.subjectSIGNAL-TRANSDUCTION
dc.subjectEXPERIMENTAL-MODELS
dc.subjectCARDIAC-SURGERY
dc.subjectSALVAGE KINASE
dc.title9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27164905
dc.format.volume111
dc.identifier.doi10.1007/s00395-016-0558-1
dc.contributor.funderBritish Health Foundation
dc.contributor.funderMedical Research Council (UK)
dc.description.peerreviewed
dc.identifier.e-issn1435-1803
dc.relation.publisherversionhttps://doi.org/10.1007/s00395-016-0558-1
dc.identifier.journalBasic Research in Cardiology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.repisalud.institucionCNIC
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional