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dc.contributor.authorBarragan, Rocio
dc.contributor.authorColtell, Oscar
dc.contributor.authorAsensio, Eva M.
dc.contributor.authorFrances, Francesc
dc.contributor.authorSorli, Jose V.
dc.contributor.authorEstruch, Ramon
dc.contributor.authorSalas-Huetos, Albert
dc.contributor.authorOrdovas, Jose M 
dc.contributor.authorCorella, Dolores
dc.date.accessioned2017-10-30T13:15:40Z
dc.date.available2017-10-30T13:15:40Z
dc.date.issued2016
dc.identifierISI:000382337900150
dc.identifier.citationInt J Mol Sci. 2016; 17(8):E1338
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5207
dc.description.abstractRecently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvencion con DIeta MEDiterranea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 +/- 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 +/- 0.4 in AA, 5.9 +/- 0.5 in AG and 9.1 +/- 1.8 g/day in GG; p(adjusted) = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (> 2 drinks/day in men and > 1 in women): 5.9\% in AA versus 17.5\% in GG; p(adjusted) < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.
dc.description.sponsorshipThis study was funded, by the Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economia y Competitividad-Fondo Europeo de Desarrollo Regional (Projects CNIC-06/2007, RTIC G03/140, CIBER 06/03, PI06-1326, PI07-0954, PI11/02505, SAF2009-12304, AGL2010-22319-C03-03 and PRX14/00527), by the lUniversity Jaume I (Project P1-1B2013-54), by Contracts 53-K06-5-10 and 58-1950-9-001 from the U.S. Department of Agriculture Research Service, USA, by the Generalitat Valenciana (ACOMP2010-181, AP111/10, AP-042/11, ACOM2011/145, ACOMP/2012/190, ACOMP/2013/159 and ACOMP/213/165), and with the collaboration of the Real Colegio Complutense at Harvard University, Cambridge. MA, USA. Rocio Barragon's contract is funded by the Ayudas para la contratacion de personal investigador en formacion de caracter predoctoral, Programa ``VALencia Investigacion mas Desarrollo´´ (VALi+d). Conselleria d'Educacio, Investigacio, Cultura i Esport. Generalitat Valenciana, Spain (ACIF/2013/168).
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMicroRNAs
dc.subjectAlcohol
dc.subjectmiR27a
dc.subjectMediterranean
dc.subjectSINGLE NUCLEOTIDE POLYMORPHISMS
dc.subjectGASTRIC-CANCER SUSCEPTIBILITY
dc.subjectFUNCTIONAL POLYMORPHISM
dc.subjectMENDELIAN RANDOMIZATION
dc.subjectCHINESE POPULATION
dc.subjectCOLORECTAL-CANCER
dc.subjectGENETIC VARIANT
dc.subjectHEART-DISEASE
dc.subjectUSE DISORDERS
dc.subjectRISK
dc.titleMicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27537871
dc.format.volume17
dc.identifier.doi10.3390/ijms17081338
dc.contributor.funderJaume I University (España) 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderUnited States Department of Agriculture. National Institute of Food and Agriculture 
dc.contributor.funderGeneralitat Valenciana (España) 
dc.contributor.funderComplutense University of Madrid (España) 
dc.contributor.funderHarvard University (Estados Unidos) 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.3390/ijms17081338
dc.identifier.journalInternational Journal of Molecular Sciences
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales
dc.repisalud.institucionCNIC
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional