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dc.contributor.authorPeñalvo, Jose L 
dc.contributor.authorFernandez-Friera, Leticia 
dc.contributor.authorLopez-Melgar, Beatriz 
dc.contributor.authorUzhova, Irina 
dc.contributor.authorOliva, Belen 
dc.contributor.authorFernandez-Alvira, Juan Miguel 
dc.contributor.authorLaclaustra, Martin 
dc.contributor.authorPocock, Stuart 
dc.contributor.authorMocoroa, Agustin
dc.contributor.authorMendiguren, Jose M
dc.contributor.authorSanz, Gines 
dc.contributor.authorGuallar, Eliseo 
dc.contributor.authorBansilal, Sameer
dc.contributor.authorVedanthan, Rajesh
dc.contributor.authorJimenez-Borreguero, Luis J. 
dc.contributor.authorIbáñez, Borja 
dc.contributor.authorOrdovas, Jose M 
dc.contributor.authorFernandez-Ortiz, Antonio 
dc.contributor.authorBueno, Hector 
dc.contributor.authorFuster, Valentin 
dc.date.accessioned2017-10-30T13:15:40Z
dc.date.available2017-10-30T13:15:40Z
dc.date.issued2016
dc.identifierISI:000381277900005
dc.identifier.citationJ Am Coll Cardiol. 2016; 68(8):805-14
dc.identifier.issn0735-1097
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5204
dc.description.abstractBACKGROUND The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. OBJECTIVES This study sought to quantify the association between specific dietary patterns and presence and extent of subclinical atherosclerosis in a population of asymptomatic middle-aged adults. METHODS The PESA (Progression of Early Subclinical Atherosclerosis) study enrolled 4,082 asymptomatic participants 40 to 54 years of age (mean age 45.8 years; 63\% male) to evaluate the presence of subclinical atherosclerosis in multiple vascular territories. A fundamental objective of this cohort study was to evaluate the life-style-related determinants, including diet, on atherosclerosis onset and development. We conducted a cross-sectional analysis of baseline data, including detailed information on dietary habits obtained as part of the overall life-style and risk factor assessment, as well as a complete vascular imaging study that was performed blinded to the clinical information. RESULTS Most PESA participants follow a Mediterranean (40\% of participants) or a Western (41\%) dietary pattern. A new pattern, identified among 19\% of participants, was labeled as a social-business eating pattern, characterized by a high consumption of red meat, pre-made foods, snacks, alcohol, and sugar-sweetened beverages and frequent eating-out behavior. Participants following this pattern presented a significantly worse cardiovascular risk profile and, after adjustment for risk factors, increased odds of presenting subclinical atherosclerosis (odds ratio: 1.31; 95\% confidence interval: 1.06 to 1.63) compared with participants following a Mediterranean diet. CONCLUSIONS A new social-business eating pattern, characterized by high consumption of red and processed meat, alcohol, and sugar-sweetened beverages, and by frequent snacking and eating out as part of an overall unhealthy life-style, is associated with an increased prevalence, burden, and multisite presence of subclinical atherosclerosis. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318) (C) 2016 by the American College of Cardiology Foundation.
dc.description.sponsorshipThis study was supported by a noncompetitive unrestricted grant shared between the National Center for Cardiovascular Research Carlos III (CNIC) and the Bank of Santander. The PESA study is a noncommercial study independent of the health care and pharmaceutical industry. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Dr. Vedanthan is supported by the Fogarty International Center of the National Institutes of Health under award K01 TW 009218-05. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr. Bueno has received advisory/speaking fees from AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, Novartis, and Servier; has received a research grant from AstraZeneca; has received advisory fees from Abbott; and has received speaking fees from Ferrer. Frank B. Hu, MD, served as Guest Editor for this paper.
dc.language.isoeng
dc.publisherElsevier 
dc.type.hasVersionVoR
dc.subjectCardiovascular disease
dc.subjectDietary patterns
dc.subjectPlaque
dc.subjectSubclinical atherosclerosis
dc.subjectINTIMA-MEDIA THICKNESS
dc.subjectMAJOR DIETARY PATTERNS
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectSUBCLINICAL ATHEROSCLEROSIS
dc.subjectMEDITERRANEAN DIET
dc.subjectRISK
dc.subjectCORONARY
dc.subjectCOHORT
dc.subjectMETAANALYSIS
dc.subjectPROGRESSION
dc.titleAssociation Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis
dc.typejournal article
dc.identifier.pubmedID27539172
dc.format.volume68
dc.format.page805-814
dc.identifier.doi10.1016/j.jacc.2016.05.080
dc.contributor.funderBanco Santander 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.contributor.funderAstraZeneca 
dc.contributor.funderBayer Healthcare Pharmaceuticals-Bayer Pharma AG 
dc.contributor.funderFundación Pfizer 
dc.contributor.funderNovartis 
dc.contributor.funderServier 
dc.contributor.funderAbbott 
dc.contributor.funderFerrer 
dc.identifier.e-issn1558-3597
dc.relation.publisherversionhttps://doi.org/10.1016/j.jacc.2016.05.080
dc.identifier.journalJournal of the American College of Cardiology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular
dc.repisalud.orgCNICCNIC::Grupos de investigación::Investigación Cardiovascular Traslacional Multidisciplinaria
dc.repisalud.institucionCNIC
dc.relation.projectIDMINECO/ICTI2013-2016/SEV-2015-0505es_ES
dc.rights.accessRightsopen accesses_ES


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