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dc.contributor.authorChamorro, Virginia
dc.contributor.authorPandolfi, Rachele
dc.contributor.authorMoreno, Laura
dc.contributor.authorBarreira, Bianca
dc.contributor.authorMartinez-Ramas, Andrea
dc.contributor.authorMorales-Cano, Daniel
dc.contributor.authorRuiz-Cabello, Jesus 
dc.contributor.authorAngel Lorente, Jose
dc.contributor.authorDuarte, Juan
dc.contributor.authorCogolludo, Angel
dc.contributor.authorLuis Alvarez-Sala, Jose
dc.contributor.authorPerez-Vizcaino, Francisco
dc.date.accessioned2017-10-20T10:33:51Z
dc.date.available2017-10-20T10:33:51Z
dc.date.issued2016
dc.identifierISI:000392140100133
dc.identifier.citationMolecules. 2016; 21(12):E1739
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5171
dc.description.abstractBackground: We hypothesized that treatment with quercetin could result in improved hemodynamics, lung inflammatory parameters and mortality in a rat model of hemorrhagic shock. Methods: Rats were anesthetized (80 mg/kg ketamine plus 8 mg/kg xylazine i.p.). The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg/kg) or vehicle were administered during resuscitation. Results: There was a trend for increased survival 84.6\% (11/13) in the treated group vs. the shock group 68.4\% (13/19, p > 0.05 Kaplan-Meier). Quercetin fully prevented the development of lung edema. The activity of aSMase was increased in the shock group compared to the sham group and the quercetin prevented this effect. However, other inflammatory markers such as myeloperoxidase activity, interleukin-6 in plasma or bronchoalveolar fluid were similar in the sham and shock groups. We found no bacterial DNA in plasma in these animals. Conclusions: Quercetin partially prevented the changes in blood pressure and lung injury in shock associated to hemorrhage and reperfusion.
dc.description.sponsorshipSupported by Fundacion Mutua Madrilena (AP102962012), Spanish MINECO (SAF 2011-28150; SAF2014-55399R; SAF2014-58920) and ISCIII (CP12/03304, FIS 15/1492).
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSystemic arterial pressure
dc.subjectLung edema
dc.subjectHemorrhage
dc.subjectTrauma
dc.subjectReperfusion
dc.subjectACID SPHINGOMYELINASE
dc.subjectFLAVONOID QUERCETIN
dc.subjectIMPROVES SURVIVAL
dc.subjectOXIDATIVE STRESS
dc.subjectINJURY
dc.subjectGUT
dc.subjectSPHINGOLIPIDS
dc.subjectCERAMIDE
dc.titleEffects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27999410
dc.format.volume21
dc.identifier.doi10.3390/molecules21121739
dc.contributor.funderFundación Mutua Madrileña 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.3390/molecules21121739
dc.identifier.journalMolecules
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzada
dc.repisalud.institucionCNIC
dc.relation.projectIDMINECO/ICTI2013-2016/SAF2014-55399Res_ES
dc.relation.projectIDMINECO/ICTI2013-2016/SAF2014-58920es_ES
dc.rights.accessRightsopen accesses_ES


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