Mostrar el registro sencillo del ítem
dc.contributor.author | Bobi, Joaquim | |
dc.contributor.author | Solanes, Nuria | |
dc.contributor.author | Fernandez-Jimenez, Rodrigo | |
dc.contributor.author | Galan-Arriola, Carlos | |
dc.contributor.author | Dantas, Ana Paula | |
dc.contributor.author | Fernandez-Friera, Leticia | |
dc.contributor.author | Galvez-Monton, Carolina | |
dc.contributor.author | Rigol-Monzo, Elisabet | |
dc.contributor.author | Aguero, Jaume | |
dc.contributor.author | Ramirez, Jose | |
dc.contributor.author | Roque, Merce | |
dc.contributor.author | Bayes-Genis, Antoni | |
dc.contributor.author | Sanchez-Gonzalez, Javier | |
dc.contributor.author | Garcia-Alvarez, Ana | |
dc.contributor.author | Sabaté, Manel | |
dc.contributor.author | Roura, Santiago | |
dc.contributor.author | Ibáñez, Borja | |
dc.contributor.author | Rigol, Montserrat | |
dc.date.accessioned | 2017-10-20T10:23:12Z | |
dc.date.available | 2017-10-20T10:23:12Z | |
dc.date.issued | 2017 | |
dc.identifier | ISI:000404098600058 | |
dc.identifier.citation | J Am Heart Assoc. 2017; 6(5):e005771 | |
dc.identifier.issn | 2047-9980 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5119 | |
dc.description.abstract | Background-Autologous adipose tissue-derived mesenchymal stem cells (ATMSCs) therapy is a promising strategy to improve post-myocardial infarction outcomes. In a porcine model of acute myocardial infarction, we studied the long-term effects and the mechanisms involved in allogeneic ATMSCs administration on myocardial performance. Methods and Results-Thirty-eight pigs underwent 50 minutes of coronary occlusion; the study was completed in 33 pigs. After reperfusion, allogeneic ATMSCs or culture medium (vehicle) were intracoronarily administered. Follow-ups were performed at short (2 days after acute myocardial infarction vehicle-treated, n=10; ATMSCs-treated, n=9) or long term (60 days after acute myocardial infarction vehicle-treated, n=7; ATMSCs-treated, n=7). At short term, infarcted myocardium analysis showed reduced apoptosis in the ATMSCs-treated animals (48.6 +/- 6\% versus 55.9 +/- 5.7\% in vehicle; P=0.017); enhancement of the reparative process with up-regulated vascular endothelial growth factor, granulocyte macrophage colony-stimulating factor, and stromal-derived factor-1 alpha gene expression; and increased M2 macrophages (67.2 +/- 10\% versus 54.7 +/- 10.2\% in vehicle; P=0.016). In long-term groups, increase in myocardial perfusion at the anterior infarct border was observed both on day-7 and day-60 cardiac magnetic resonance studies in ATMSCs-treated animals, compared to vehicle (87.9 +/- 28.7 versus 57.4 +/- 17.7 mL/min per gram at 7 days; P=0.034 and 99 +/- 22.6 versus 43.3 +/- 14.7 22.6 mL/min per gram at 60 days; P=0.0001, respectively). At day 60, higher vascular density was detected at the border zone in the ATMSCs-treated animals (118 +/- 18 versus 92.4 +/- 24.3 vessels/mm(2) in vehicle; P=0.045). Cardiac magnetic resonance-measured left ventricular ejection fraction of left ventricular volumes was not different between groups at any time point. Conclusions-In this porcine acute myocardial infarction model, allogeneic ATMSCs-based therapy was associated with increased cardioprotective and reparative mechanisms and with better cardiac magnetic resonance-measured perfusion. No effect on left ventricular volumes or ejection fraction was observed. | |
dc.description.sponsorship | This work was supported by grants from Fundacion la Marato de TV3 (122230); Fondo de Investigacion Sanitaria Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional (FIS PI14/01682), (RD12/0042/0006), (RD12/0042/0047), (RD12/0019/0029) (TerCel RD16/0011/0006), CIBER Cardiovascular (CB16/11/00403) projects and Ministerio de Educacion y Ciencia (SAF2011-30067-C02-01) (SAF2014-59892). Fernaandez-Jimenez was the recipient of nonoverlapping grants from the Ministerio de Economia, Industria, y Competitividad through the Instituto de Salud Carlos III (Rio Hortega fellowship); and the Fundacion Jesus Serra, the Fundacion Interhospitalaria de Investigacion Cardiovascular (FIC), and the CNIC (FICNIC fellowship). The use of QMass software was partly supported by a scientific collaboration between the CNIC and Medis Medical Imaging Systems BV. The CNIC is supported by the Ministerio de Economia, Industria, y Competitividad (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). This work was also funded by ``la Caixa Banking Foundation, and the Generalitat de Catalunya (SGR 2014, CERCA Programme). This work has been developed in the context of AdvanceCat with the support of ACCIO (Catalonia Trade \& Investment; Generalitat de Catalunya) under the Catalonian ERDF operational program (European Regional Development Fund) 2014-2020. | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | adipose tissue-derived mesenchymal stem cells | |
dc.subject | allogeneic origin | |
dc.subject | myocardial infarction | |
dc.subject | myocardial perfusion | |
dc.subject | vascular density | |
dc.subject | RANDOMIZED PHASE-1 TRIAL | |
dc.subject | CARDIAC-FUNCTION | |
dc.subject | ISCHEMIC CARDIOMYOPATHY | |
dc.subject | PROMOTE ANGIOGENESIS | |
dc.subject | PROGENITOR CELLS | |
dc.subject | HEART-FAILURE | |
dc.subject | PORCINE MODEL | |
dc.subject | DISEASE | |
dc.subject | THERAPY | |
dc.subject | ISCHEMIA/REPERFUSION | |
dc.title | Intracoronary Administration of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction | |
dc.type | journal article | |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 28468789 | |
dc.format.volume | 6 | |
dc.identifier.doi | 10.1161/JAHA.117.005771 | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | |
dc.contributor.funder | Fundación Jesús Serra | |
dc.contributor.funder | Fundación Interhospitalaria de Investigación Cardiovascular | |
dc.contributor.funder | Medis Medical Imaging | |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Government of Catalonia (España) | |
dc.contributor.funder | Fundación La Marató TV3 | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1161/JAHA.117.005771 | |
dc.identifier.journal | Journal of the American Heart Association | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovascular | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/ES6/SAF2014-59892 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01682 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0042/0006 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0042/0047 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0019/0029 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16/0011/0006 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CB16/11/00403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2011-30067-C02-01 | es_ES |
dc.rights.accessRights | open access | es_ES |