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dc.contributor.authorZaldo, Carlos
dc.contributor.authorDolores Serrano, Maria
dc.contributor.authorHan, Xiumei
dc.contributor.authorCascales, Concepcion
dc.contributor.authorCantero, Marta
dc.contributor.authorMontoliu, Lluis
dc.contributor.authorArza, Elvira 
dc.contributor.authorCaiolfa, Valeria R 
dc.contributor.authorZamai, Moreno 
dc.date.accessioned2017-10-20T10:23:11Z
dc.date.available2017-10-20T10:23:11Z
dc.date.issued2017
dc.identifierISI:000401672400055
dc.identifier.citationPLoS One. 2017; 12(5):e0177596
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5116
dc.description.abstractYb and Er codoped NaT(XO4)(2) (T = Y, La, Gd, Lu and X = Mo, W) disordered oxides show a green (Er3+ related) up-conversion (UC) efficiency comparable to that of Yb:Er:beta-NaYF4 compound and unless 3 times larger UC ratiometric thermal sensitivity. The similar UC efficiency of Yb:Er doped NaT(XO4)(2) and beta-NaYF4 compounds allowed testing equal subcutaneous depths of ex-vivo chicken tissue in both cases. This extraordinary behavior for NaT (XO4)(2) oxides with large cutoff phonon energy (h omega approximate to 920 cm(-1)) is ascribed to F-4(9/2) electron population recycling to higher energy (4)G(11/2) level by a phonon assisted transition. Crystalline nanoparticles of Yb:Er:NaLu(MoO4)(2) have been synthesized by sol-gel with sizes most commonly in the 50-80 nm range, showing a relatively small reduction of the UC efficiency with regards to bulk materials. Fluorescence lifetime and multiphoton imaging microscopies show that these nanoparticles can be efficiently distributed to all body organs of a perfused mouse.
dc.description.sponsorshipThe authors thankfully acknowledge the financial support by Ministry of Economy and Competitiveness and the European Regional Development Fund grant number MAT2014-56607-R, the Spanish Ministry of Economy and Competitiveness support as a Severo Ochoa Center of Excellence, grant nunber SEV-2015-0505, and by the Pro CNIC Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; This work has been supported by the Ministry of Economy and Competitiveness (MINECO) and by the European Regional Development Fund through MAT2014-56607-R project. The CNIC is supported by the Ministry of Economy, Industry and Competitiveness (MEIC) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Optical microscopy was carried out at the Molecular and Functional Imaging Unit, ICTS ReDIB TRIMA@CNIC. The authors are in debt with the histology facility of CNB-CSIC for tissue section preparation and with A. M. Santos Beneit (CNIC) for his help in image analysis.
dc.language.isoeng
dc.publisherPublic Library of Science (PLOS) 
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPHOTOLUMINESCENCE PROPERTIES
dc.subjectUPCONVERTING NANOPARTICLES
dc.subjectPHOTODYNAMIC THERAPY
dc.subjectBIOLOGICAL TISSUE
dc.subjectDRUG-DELIVERY
dc.subjectLUMINESCENCE
dc.subjectTEMPERATURE
dc.subjectCRYSTALS
dc.subjectNANOCRYSTALS
dc.subjectMICROSCOPY
dc.titleEfficient up-conversion in Yb:Er:NaT(XO4)(2) thermal nanoprobes. Imaging of their distribution in a perfused mouse
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID28542327
dc.format.volume12
dc.identifier.doi10.1371/journal.pone.0177596
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0177596
dc.identifier.journalPlos One
dc.repisalud.orgCNICCNIC::Unidades técnicas::Microscopía
dc.repisalud.institucionCNIC
dc.relation.projectIDMINECO/ICTI2013-2016/SEV-2015-0505es_ES
dc.relation.projectIDMINECO/ICTI2013-2016/MAT2014-56607-Res_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional