Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5104
Mitochondria in endothelial cells: Sensors and integrators of environmental cues
Redox Biol. 2017; 12:821-827
The involvement of angiogenesis in disease and its potential as a therapeutic target have been firmly established over recent decades. Endothelial cells (ECs) are central elements in vessel homeostasis and regulate the passage of material and cells into and out of the bloodstream. EC proliferation and migration are modified by alterations to mitochondrial biogenesis and dynamics resulting from several signals and environmental cues, such as oxygen, hemodynamics, and nutrients. As intermediary signals, mitochondrial ROS are released as important downstream modulators of the expression of angiogenesis-related genes. In this review, we discuss the physiological actions of these signals and aberrant responses during vascular disorders.
Endothelial cells | Mitochondria | Biogenesis | Dynamics | ROS | DYNAMIN-RELATED PROTEIN-1 | VASCULAR SMOOTH-MUSCLE | LAMINAR SHEAR-STRESS | BLOOD-BRAIN-BARRIER | OXYGEN SPECIES ROS | OXIDATIVE STRESS | ANGIOTENSIN-II | NITRIC-OXIDE | CARDIOVASCULAR-SYSTEM | ADHESION MOLECULE-1
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