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Regulation and diagnosis of cardiovascular diseases by microRNAs derived from immune cells 

Cardiovascular diseases are the main cause of mortality and morbidity worldwide. Adequate management of acute cardiac conditions, such as myocarditis and myocardial infarction (MI), relies on an early diagnosis. However, diagnosis is often presented as a clinical challenge due to the uncharacterist...

Cytoskeletal remodeling and enhanced autophagy drive an adaptive response to loss of Calsequestrin in a model of inherited arrhythmias 

Calcium transients between the Sarcoplasmic Reticulum (SR) and the cytoplasm are essential for coordinated contraction in cardiomyocytes. Loss of the SR protein Calsequestrin 2 (CASQ2) causes the recessive form of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT2) by increasing the diast...

Polybacterial mucosal vaccine protects against viral respiratory infections and induces trained immunity 

Recurrent respiratory tract infections (RRTI) are very frequent in childhood due to the immature state of the immune system and the traditional therapeutic strategies just rely on antibiotic treatments. However, the etiology of RRTIs is diverse, with viruses being the most common cause of the disea...

Caracterización de la mutación R735X de PKP2 en el fenotipo estructural de la Cardiomiopatía Arritmogénica 

La forma genética más prevalente en la cardiomiopatía arritmogénica (ACM, del inglés “arrhythmogenic cardiomyopathy”) es causada por mutaciones en la placofilina-2 (PKP2). La mayoría de las mutaciones en PKP2 descritas en pacientes con ACM, generan proteínas truncadas. Sin embargo, los mecanismos a...

Stress kinases in the regulation of inter-organ communication in obesity comorbidities 

Obesity is characterized by the excessive fat accumulation that develops when energy intake exceeds energy expenditure. Lifestyle changes have increased the prevalence of obesity, which has become a major health problem. In fact, obesity is a well-known risk factor for several chronic diseases, inc...

Dynamics of LDL accumulation leading to atherosclerosis initiation 

Objective – Atherosclerosis is caused by the accumulation of LDL at atherosclerosissusceptible sites. This requires LDLs to pass through the endothelium and be retained in the arterial intima, but which process is rate-limiting and predicts atherosclerosis has remained controversial. To answer this...

The role of Meis transcription factors in the epicardium 

A single layer of cells could be perceived as insignificant in comparison to a whole organ. However, extensive evidence has shown that the epicardium, the outermost layer of the heart, is essential for cardiac development and regeneration. Epicardium-derived cells (EPDCs) and epicardial signalling ...

miRNA dynamics in T cell activation 

MiRNA repertoire of T cells undergoes extensive changes in response to activation. Beyond a global decrease in miRNA levels few hours after activation, some individual miRNAs are specifically up-regulated or down-regulated. We have assessed miRNA expression and post-transcriptional modification kin...

P53 and PUMA in Pluripotent Cell Competition 

Cell Competition (CC) is a biological process in which viable cells are eliminated by the presence of neighbouring cells with increased fitness. First observed in Drosophila, Cell Competition has been described in numerous biological scenarios in metazoans both du¬ring embryonic development and in ...

Characterization of hematopoietic stem cells in the circulation 

Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate into multiple cell lineages, giving rise to all blood components and immune cells, during the entire life of an individual. HSCs are localized in the bone marrow inside specialized compartments named “hematopoietic nic...

Deciphering regulatory elements as determinants of cardiovascular diseases 

The non-coding genome harbors cis-regulatory elements (CRE) that control gene expression in time and space. A tight control of transcription is of great importance, especially during development, and CRE disruption may lead to malformations and other congenital diseases. Genome-wide association stu...

Mechanisms involved in quiescent blood vessel homeostasis 

Our vascular system is an organized and hierarchical blood vessel network lined by a monolayer of endothelial cells (ECs) that supplies oxygen and nutrients to all tissues and organs in our body. Importantly, they are not passive conduits for blood flow and they contribute to organ physiology and h...

Adhesion G protein-coupled receptor Gpr126 signaling is essential for placental development 

Gpr126 is an adhesion G protein-coupled receptor (GPCR) that is required for peripheral nervous system (PNS) development in mice and zebrafish. In the heart, Gpr126 is expressed in the endocardium and its inactivation in mice leads to embryonic lethality and defective ventricular trabeculation. Th...

Unraveling the molecular mechanisms behind the regulation of mesenchymal cell proliferation during cardiac valve remodeling 

The importance of the cardiac valves is apparent when one considers how often they are required to open and shut on a minute-to-minute basis. The complexity of their formation is underlined by the frequent involvement of valvular defects in several forms of congenital heart disease. Even though man...

Papel de la lamina A/C en la enfermedad cardiovascular asociada al envejecimiento 

Las enfermedades cardiovasculares (ECVs) son la primera causa de mortalidad en el mundo. El envejecimiento y la hipercolesterolemia son dos factores de riesgo cardiovascular muy importantes. La lamina A/C es una proteína nuclear codificada por el gen LMNA que juega un papel estructural y regulador ...

New insights into anthracyline-induced cardiotoxicity 

The increasing life expectancy of the population and the development of effective anticancer therapies result in a growing population of aged cancer survivors, which frequently have comorbidities for developing heart failure (HF). Anthracyclines are still first line treatment for many cancer types,...

Papel de la proteasa MT4-MMP como modulador de los monocitos patrulleros en el contexto inflamatorio 

Los monocitos patrulleros son una población de leucocitos circulantes en la sangre encargados de rastrear el endotelio de los vasos, detectando daño celular y captando partículas nocivas tanto en condiciones de homeostasis como durante procesos inflamatorios. En nuestro trabajo hemos caracterizado ...

Defining novel physiological roles for cardiac-residen Macrophages 

Classically defined as defensive cells, macrophages are now known to be endowed with tissue-specific tasks unrelated to immunity (Davies et al., 2013). These pleiotropic functions are prominent in the heart, where tissue-resident macrophages have been shown to prevent fibrosis (Chakarov et al., 20...

Ventricular tachycardia (VT): Mortality implications in patients with cardiomyopathy, impact of VT ablation and development of new invasive treatment strategies. 

Background Ventricular tachycardia (VT) is a common complication affecting patients with structural heart disease and poor left ventricular systolic function. Its occurrence is linked to increased mortality despite treatment with an implantable cardioverter defibrillator (ICD) and there are severa...

Caracterización de la función de SRSF4 en la homeostasis del corazón 

Las enfermedades cardiovasculares constituyen la mayor causa de muerte a nivel mundial, sin embargo la regulación de los mecanismos post-transcripcionales y el papel de las proteínas de unión a RNA (RBPs) en estas enfermedades continúa siendo un campo por descubrir. Estudios recientes muestran que ...