Recent Submissions

P53 and PUMA in Pluripotent Cell Competition 

Cell Competition (CC) is a biological process in which viable cells are eliminated by the presence of neighbouring cells with increased fitness. First observed in Drosophila, Cell Competition has been described in numerous biological scenarios in metazoans both du¬ring embryonic development and in ...

Characterization of hematopoietic stem cells in the circulation 

Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate into multiple cell lineages, giving rise to all blood components and immune cells, during the entire life of an individual. HSCs are localized in the bone marrow inside specialized compartments named “hematopoietic nic...

Deciphering regulatory elements as determinants of cardiovascular diseases 

The non-coding genome harbors cis-regulatory elements (CRE) that control gene expression in time and space. A tight control of transcription is of great importance, especially during development, and CRE disruption may lead to malformations and other congenital diseases. Genome-wide association stu...

Mechanisms involved in quiescent blood vessel homeostasis 

Our vascular system is an organized and hierarchical blood vessel network lined by a monolayer of endothelial cells (ECs) that supplies oxygen and nutrients to all tissues and organs in our body. Importantly, they are not passive conduits for blood flow and they contribute to organ physiology and h...

Adhesion G protein-coupled receptor Gpr126 signaling is essential for placental development 

Gpr126 is an adhesion G protein-coupled receptor (GPCR) that is required for peripheral nervous system (PNS) development in mice and zebrafish. In the heart, Gpr126 is expressed in the endocardium and its inactivation in mice leads to embryonic lethality and defective ventricular trabeculation. Th...

Unraveling the molecular mechanisms behind the regulation of mesenchymal cell proliferation during cardiac valve remodeling 

The importance of the cardiac valves is apparent when one considers how often they are required to open and shut on a minute-to-minute basis. The complexity of their formation is underlined by the frequent involvement of valvular defects in several forms of congenital heart disease. Even though man...

Papel de la lamina A/C en la enfermedad cardiovascular asociada al envejecimiento 

Las enfermedades cardiovasculares (ECVs) son la primera causa de mortalidad en el mundo. El envejecimiento y la hipercolesterolemia son dos factores de riesgo cardiovascular muy importantes. La lamina A/C es una proteína nuclear codificada por el gen LMNA que juega un papel estructural y regulador ...

New insights into anthracyline-induced cardiotoxicity 

The increasing life expectancy of the population and the development of effective anticancer therapies result in a growing population of aged cancer survivors, which frequently have comorbidities for developing heart failure (HF). Anthracyclines are still first line treatment for many cancer types,...

Papel de la proteasa MT4-MMP como modulador de los monocitos patrulleros en el contexto inflamatorio 

Los monocitos patrulleros son una población de leucocitos circulantes en la sangre encargados de rastrear el endotelio de los vasos, detectando daño celular y captando partículas nocivas tanto en condiciones de homeostasis como durante procesos inflamatorios. En nuestro trabajo hemos caracterizado ...

Defining novel physiological roles for cardiac-residen Macrophages 

Classically defined as defensive cells, macrophages are now known to be endowed with tissue-specific tasks unrelated to immunity (Davies et al., 2013). These pleiotropic functions are prominent in the heart, where tissue-resident macrophages have been shown to prevent fibrosis (Chakarov et al., 20...

Ventricular tachycardia (VT): Mortality implications in patients with cardiomyopathy, impact of VT ablation and development of new invasive treatment strategies. 

Background Ventricular tachycardia (VT) is a common complication affecting patients with structural heart disease and poor left ventricular systolic function. Its occurrence is linked to increased mortality despite treatment with an implantable cardioverter defibrillator (ICD) and there are severa...

Caracterización de la función de SRSF4 en la homeostasis del corazón 

Las enfermedades cardiovasculares constituyen la mayor causa de muerte a nivel mundial, sin embargo la regulación de los mecanismos post-transcripcionales y el papel de las proteínas de unión a RNA (RBPs) en estas enfermedades continúa siendo un campo por descubrir. Estudios recientes muestran que ...

Generation and characterization of a new conditional mouse model of Hutchinson-Gilford Progeria Syndrome to assess disease progression upon progerin suppression and lamin A restoration 

Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal genetic disorder characterized by accelerated aging and premature death at an average age of 14.6 years. “Classical” HGPS is caused by a heterozygous de novo c.1824 C>T dominant synonymous point mutation in the LMNA gene, which encodes for...

Modelling the heterogeneity and complex inheritance of Left Ventricular Non-Compaction 

The compaction or formation of a thick and smooth cardiac ventricular wall is a fundamental process for cardiac function. This process takes place during late gestation and early postnatal period, and it is regulated by intercellular signalling from endocardium that controls myocardial proliferatio...

Novel mechanisms underlying macrophage contribution to cardiac injury after myocardial infarction 

Myocardial infarction (MI) is a recognized inflammatory condition that triggers monocyte infiltration and subsequent macrophage differentiation aiming to heal the damage. In the last few years, a growing body of evidence that a timely macrophage expansion and transition from inflammatory to repara...

The role of the beta3-adrenergic receptor in animal models of cardiac injury 

The β-adrenergic system is a key player in the regulation of the heart function. The role of the β1- and the β2- adrenergic receptors is well established and they are common targets of the medical treatment used in clinical practice. However the role of the β3-adrenergic receptor (β3AR) in the car...

Study of Midkine-a and Caveolin-1 in zebrafish heart regeneration 

Zebrafish have the ability to regenerate cardiac tissue after injury in contrast to mammals. Cryoinjury of the heart triggers a regenerative program that includes inflammatory response, cell proliferation and formation of a transient scar that eventually lead to complete tissue regeneration. This t...

CD69 controls inflammation in transplant rejection and cardiovascular diseases 

The early lymphocyte activation antigen CD69 is a transmembrane protein that is induced early after activation of all bone marrow-derived cells except erythrocytes. It has been described as an anti-inflammatory molecule that negatively regulates inflammation. CD69 deficient mice display enhanced Th...

Deciphering the mechanisms of the arrhythmogenic R735X 

Ventricular arrhythmias (VA) appear during the concealed phase of arrhythmogenic cardiomyopathy (AC). This VA can lead to sudden cardiac death, being in many cases, the first symptom of the disease. Mutations on the desmosomal gene Plakophilin-­‐2 (PKP2) have been described as the most prevalent ge...

Mitochondrial DNA transfer through Exomes during Immune Synapsis primes Antiviral Innate Immune Response in Dendritic Cells 

The generation of a specific immune response against a pathogen requires the initial interaction of an antigen-specific T cell with antigen-presenting cells (APCs), specifically dendritic cells (DCs). T cell recognition of major histocompatibility complex (MHC) bound to antigens leads to the format...