Recent Submissions

Role of Calcineurin in the development of cardiac hypertrophy 

Previous studies have shown that the Calcineurin (CN)/NFAT signalling pathway is an established important regulator of cardiac hypertrophy. However, most studies are based on gain- and loss-of-function initiated at or before birth, and there are no detailed studies about the role of this pathway in...

Differential regulation of Adamts-1 gene expression by VEGF and Angiotensin-II in endothelial and vascular smooth muscle cells 

Vascular remodeling consists of the structural alteration and arrangement of blood vessels. During this process cell migration, proliferation, cell death, and modifications in extracellular matrix (ECM) components are produced. It is present in major vascular diseases such as hypertension, aneurysm...

Adamts1 in vascular homeostasis and remodelling 

Aneurysms involving the aortic root and the ascending aorta leading to dissections are the major diseases affecting the aorta and a common cause of premature deaths ranking as high as the XXth cause of death in developed countries. The major constituent of the vessel wall is the extracellular matri...

Predictive Values of the Ideal Cardiovascular Health and the Fuster-BEWAT Scores for Detecting Subclinical Atherosclerosis in Healthy Individuals 

Background: The Ideal Cardiovascular Health Score (ICHS) has been validated for predicting CV event risk. The Fuster-BEWAT Score (FBS) is simpler as it does not use laboratory parameters (cholesterol and fasting glucose). The predictive value of these scores to detect the extent of subclinical athe...

Reproducibility of Three-Dimensional Vascular Ultrasound for the Detection and Quantification of Early Atherosclerosis: A FAMILIA Substudy 

Introduction: Three-dimensional vascular ultrasound (3DVUS) offers promise for cardiovascular risk stratification in the general population. However, 3DVUS reproducibility in early stages of atherosclerosis disease has not been well stablished. Objective: To determine 3DVUS agreement and reprodu...

Racial Disparities in Early Subclinical Atherosclerosis: Insights from the FAMILIA Study 

Introduction: African-Americans are at a greater risk of cardiovascular (CV) events. Differential race vulnerability to early subclinical atherosclerosis disease is likely, and yet few studies have addressed this relationship. Objective: To study the impact of race on the presence of early subcl...

Child Health Promotion in Underserved Communities: Primary Results From the Cluster Randomized FAMILIA Trial 

Introduction: Preschool-based interventions offer promise to instill healthy behaviors in children. However, its efficacy in underserved communities is not well established. Objective: To assess the impact of a preschool-based health promotion education intervention in an underserved community. ...

Low Dose Aspirin for Primary Prevention of Cardiovascular Disease: Use Patterns and Impact Across Race in the Southern Community Cohort Study 

Background: There are little data on the role of aspirin for primary prevention of cardiovascular disease (CVD) in racial groups. Our objective was to study the association between aspirin use patterns and CVD incidence by race in the Southern Community Cohort Study. Methods: A total of 44,177 adu...