El área científica del CNIC se organiza en dos departamentos orientados a Investigación Básica e Investigación Clínica, completamente interconectados a través de seis programas multidisciplinares agrupados en tres áreas de investigación: Fisiopatología Vascular, Fisiopatología del Miocardio y Biología Celular y del Desarrollo

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A Novel Circulating MicroRNA for the Detection of Acute Myocarditis. 

The diagnosis of acute myocarditis typically requires either endomyocardial biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not universally available). Additional approaches to diagnosis are desirable. We sought to identify a novel microRNA for the diagnosis of acu...

Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences. 

This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold. CMR is the reference tool for cardiac imaging but is time-consuming. A...

The challenge of sustainability: Long-term results from the Fifty-Fifty peer group-based intervention in cardiovascular risk factors. 

The Fifty-Fifty trial demonstrated that a peer-group-based intervention was able to improve healthy behaviors in individuals with cardiovascular (CV) risk factors immediately post-intervention. To determine the long-term sustainability of a one-year peer-group-based intervention focused on CV heal...

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics 

Titin, as the main protein responsible for the passive stiffness of the sarcomere, plays a key role in diastolic function and is a determinant factor in the etiology of heart disease. Titin stiffness depends on unfolding and folding transitions of immunoglobulin-like (Ig) domains of the I-band, and...

Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development. 

Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that act as biological sensors and use a combination of mechanisms to modulate positively and negatively gene expression in a spatial and temporal manner. The highly orchestrated biological actions of several NRs in...

Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells. 

Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins influences the efficiency of T-cell priming. To address this...

Endogenous and combination retinoids are active in myelomonocytic leukemias. 

Retinoid therapy transformed response and survival outcomes in acute promyelocytic leukemia (APL), but has demonstrated only modest activity in non-APL forms of acute myeloid leukemia (AML). The presence of natural retinoids in vivo could influence the efficacy of pharmacologic agonists and antagon...

The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders 

Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes. Correct control of their target genes requires tight regulation of the expression of different PPAR isoforms in each tissu...

Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease. 

The heart is the first organ to acquire its physiological function during development, enabling it to supply the organism with oxygen and nutrients. Given this early commitment, cardiomyocytes were traditionally considered transcriptionally stable cells fully committed to contractile function. Howe...

Cytoskeletal remodeling and enhanced autophagy drive an adaptive response to loss of Calsequestrin in a model of inherited arrhythmias 

Calcium transients between the Sarcoplasmic Reticulum (SR) and the cytoplasm are essential for coordinated contraction in cardiomyocytes. Loss of the SR protein Calsequestrin 2 (CASQ2) causes the recessive form of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT2) by increasing the diast...

Ethnic Disparities in Metabolic Syndrome Among Caregivers of Preschool Children in a Community-Based Trial 

Introduction: Obesity and dyslipidemia are increasingly prevalent, disproportionately affecting low-income families. We studied the presence of metabolic syndrome (MetS) by ethnicity among caregivers of preschool children in Harlem, New York. Methods: We analyzed 553 Hispanic and non-Hispanic bl...

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells. 

RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells, we unexpectedly identified RXRA DT448/9PP as a...

Polybacterial mucosal vaccine protects against viral respiratory infections and induces trained immunity 

Recurrent respiratory tract infections (RRTI) are very frequent in childhood due to the immature state of the immune system and the traditional therapeutic strategies just rely on antibiotic treatments. However, the etiology of RRTIs is diverse, with viruses being the most common cause of the disea...

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity. 

Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. Forty Large-White pigs were included. In Study 1, 20...

Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C. 

ECM composition and architecture are tightly regulated for tissue homeostasis. Different disorders have been associated to alterations in the levels of proteins such as collagens, fibronectin (FN) or tenascin-C (TnC). TnC emerges as a key regulator of multiple inflammatory processes, both during ph...

Effectiveness of anakinra for tocilizumab-refractory severe COVID-19: A single-centre retrospective comparative study. 

A subgroup of patients with SARS-CoV-2 infection was thought to have developed cytokine release syndrome and were treated with tocilizumab; however, a significant percentage of patients evolved. This study aimed to determine the usefulness of anakinra as a rescue treatment for patients with tociliz...

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism. 

Arterial lactate is an established risk marker in patients with pulmonary embolism (PE). However, its clinical applicability is limited by the need of an arterial puncture. In contrast, venous lactate can easily be measured from blood samples obtained via routine peripheral venepuncture. We invest...

microRNA Fine-Tuning of the Germinal Center Response. 

Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. ...

Recent advances in the pharmacotherapy of pulmonary hypertension: practical considerations. 

Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary vascular remodeling leading to increased vascular resistance. The increased afterload contributes to the development of right ventricular dysfunction and heart failure, which is the leading cause of death among patie...

Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker. 

Spontaneous Coronary Artery Dissection (SCAD) is an important cause of acute coronary syndromes, particularly in young to middle-aged women. Differentiating acute SCAD from coronary atherothrombosis remains a major clinical challenge. A case-control study was used to explore the usefulness of circ...