El Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) es un centro de investigación de excelencia reconocida internacionalmente dedicado a comprender las bases fundamentales de la salud y la enfermedad cardiovascular y trasladar dicho conocimiento al paciente. Fue fundado en 1999 por el Ministerio de Sanidad y está localizado en el Instituto de Salud Carlos III de Madrid. La actual configuración del CNIC comienza en 2006 gracias a una colaboración entre el Gobierno Español y la Fundación Pro CNIC, formada por 14 de las más importantes empresas y fundaciones privadas españolas. El CNIC tiene como objetivo final que el conocimiento generado se traduzca en un beneficio para la sociedad y en un retorno tangible para el sector público español. Todos sus recursos están orientados a trasladar los resultados de investigación a la práctica clínica y al sector empresarial. De esta forma promueve la interacción de investigadores básicos y clínicos y es pionero en su conjunto de proyectos clínicos y observacionales con estudios poblacionales, una de las grandes apuestas del centro.

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Recent Submissions

The role of Meis transcription factors in the epicardium 

A single layer of cells could be perceived as insignificant in comparison to a whole organ. However, extensive evidence has shown that the epicardium, the outermost layer of the heart, is essential for cardiac development and regeneration. Epicardium-derived cells (EPDCs) and epicardial signalling ...

miRNA dynamics in T cell activation 

MiRNA repertoire of T cells undergoes extensive changes in response to activation. Beyond a global decrease in miRNA levels few hours after activation, some individual miRNAs are specifically up-regulated or down-regulated. We have assessed miRNA expression and post-transcriptional modification kin...

Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts. 

Oxidative stress is known to induce early replicative senescence. Senescence has been proposed to work as a barrier to immortalization and tumor development. Here, we aimed to evaluate the impact of the loss of peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α), a master regulato...

Efficacy of psychological interventions on psychological outcomes in coronary artery disease: systematic review and meta-analysis. 

The benefits of cognitive-behavioral treatment (CBT) and positive psychology therapy (PPT) in patients with cardiovascular disease are still not well defined. We assessed the efficacy of CBT and PPT on psychological outcomes in coronary artery disease (CAD) patients. Randomized controlled trials e...

Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition. 

Myc is considered an essential transcription factor for heart development, but cardiac defects have only been studied in global Myc loss-of-function models. Here, we eliminated Myc by recombining a Myc floxed allele with the Nkx2.5Cre driver. We observed no anatomical, cellular or functional altera...

Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish. 

The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration. It is derived from the proepicardium (PE), groups of cells that emerges at early developmental stages from the dorsal pericardial layer (DP) clo...

Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism. 

Liver metabolism follows diurnal fluctuations through the modulation of molecular clock genes. Disruption of this molecular clock can result in metabolic disease but its potential regulation by immune cells remains unexplored. Here, we demonstrated that in steady state, neutrophils infiltrated the ...

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma. 

Most B cell lymphomas originate from B cells that have germinal center (GC) experience and bear chromosome translocations and numerous point mutations. GC B cells remodel their immunoglobulin (Ig) genes by somatic hypermutation (SHM) and class switch recombination (CSR) in their Ig genes. Activatio...

Single breath-hold saturation recovery 3D cardiac T1 mapping via compressed SENSE at 3T. 

To propose and validate a novel imaging sequence that uses a single breath-hold whole-heart 3D T1 saturation recovery compressed SENSE rapid acquisition (SACORA) at 3T. The proposed sequence combines flexible saturation time sampling, compressed SENSE, and sharing of saturation pulses between two ...

Intestinal Epithelial Cell-Derived Extracellular Vesicles Modulate Hepatic Injury via the Gut-Liver Axis During Acute Alcohol Injury. 

Binge drinking, i.e., heavy episodic drinking in a short time, has recently become an alarming societal problem with negative health impact. However, the harmful effects of acute alcohol injury in the gut-liver axis remain elusive. Hence, we focused on the physiological and pathological changes and...

Uncovering the Role of p38 Family Members in Adipose Tissue Physiology. 

The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipos...

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance. 

Therapy resistance is responsible for most relapses in patients with cancer and is the major challenge to improving the clinical outcome. The pseudokinase Tribbles homologue 2 (TRIB2) has been characterized as an important driver of resistance to several anti-cancer drugs, including the dual ATP-co...

The chaperonin CCT controls T cell receptor-driven 3D configuration of centrioles. 

T lymphocyte activation requires the formation of immune synapses (IS) with antigen-presenting cells. The dynamics of membrane receptors, signaling scaffolds, microfilaments, and microtubules at the IS determine the potency of T cell activation and subsequent immune response. Here, we show that the...

ECM deposition is driven by caveolin-1-dependent regulation of exosomal biogenesis and cargo sorting. 

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction critically depends on cell communication mediated by exosomes, small vesicles genera...

Immune Regulation by Dendritic Cell Extracellular Vesicles in Cancer Immunotherapy and Vaccines. 

Extracellular vesicles (EVs) play a crucial role in intercellular communication as vehicles for the transport of membrane and cytosolic proteins, lipids, and nucleic acids including different RNAs. Dendritic cells (DCs)-derived EVs (DEVs), albeit variably, express major histocompatibility complex (...

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. 

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow (BM) microenvironment for survival, but the underlying mechanisms remain largely unknown. We have studied the contribution of nestin+ BM mesenchymal stem cells (BMSCs) to MLL-AF9-driven acute myeloid leukemia (AML...

Neurohormonal Modulation as a Therapeutic Target in Pulmonary Hypertension. 

The autonomic nervous system (ANS) and renin-angiotensin-aldosterone system (RAAS) are involved in many cardiovascular disorders, including pulmonary hypertension (PH). The current review focuses on the role of the ANS and RAAS activation in PH and updated evidence of potential therapies targeting ...

Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction. 

Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these factors crosstalk with other cell types mediating repair is not fully understood. Here we demonstrated that cardiac Mφs increased the expression of Mmp14 (MT1-MMP...

Structural and Functional Brain Abnormalities in Mouse Models of Lafora Disease. 

Mutations in the EPM2A and EPM2B genes, encoding laforin and malin proteins respectively, are responsible for Lafora disease, a fatal form of progressive myoclonus epilepsy with autosomal recessive inheritance. Neuroimaging studies of patients with Lafora disease have shown different degrees of bra...

Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction. 

microRNAs are master regulators of gene expression with essential roles in virtually all biological processes. miR-217 has been associated with aging and cellular senescence, but its role in vascular disease is not understood. Approach and Results: We have used an inducible endothelium-specific kno...