El Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) es un centro de investigación de excelencia reconocida internacionalmente dedicado a comprender las bases fundamentales de la salud y la enfermedad cardiovascular y trasladar dicho conocimiento al paciente. Fue fundado en 1999 por el Ministerio de Sanidad y está localizado en el Instituto de Salud Carlos III de Madrid. La actual configuración del CNIC comienza en 2006 gracias a una colaboración entre el Gobierno Español y la Fundación Pro CNIC, formada por 14 de las más importantes empresas y fundaciones privadas españolas. El CNIC tiene como objetivo final que el conocimiento generado se traduzca en un beneficio para la sociedad y en un retorno tangible para el sector público español. Todos sus recursos están orientados a trasladar los resultados de investigación a la práctica clínica y al sector empresarial. De esta forma promueve la interacción de investigadores básicos y clínicos y es pionero en su conjunto de proyectos clínicos y observacionales con estudios poblacionales, una de las grandes apuestas del centro.

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Recent Submissions

Polybacterial mucosal vaccine protects against viral respiratory infections and induces trained immunity 

Recurrent respiratory tract infections (RRTI) are very frequent in childhood due to the immature state of the immune system and the traditional therapeutic strategies just rely on antibiotic treatments. However, the etiology of RRTIs is diverse, with viruses being the most common cause of the disea...

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity. 

Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. Forty Large-White pigs were included. In Study 1, 20...

Extracellular Vesicles: An Emerging Mechanism Governing the Secretion and Biological Roles of Tenascin-C. 

ECM composition and architecture are tightly regulated for tissue homeostasis. Different disorders have been associated to alterations in the levels of proteins such as collagens, fibronectin (FN) or tenascin-C (TnC). TnC emerges as a key regulator of multiple inflammatory processes, both during ph...

Effectiveness of anakinra for tocilizumab-refractory severe COVID-19: A single-centre retrospective comparative study. 

A subgroup of patients with SARS-CoV-2 infection was thought to have developed cytokine release syndrome and were treated with tocilizumab; however, a significant percentage of patients evolved. This study aimed to determine the usefulness of anakinra as a rescue treatment for patients with tociliz...

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism. 

Arterial lactate is an established risk marker in patients with pulmonary embolism (PE). However, its clinical applicability is limited by the need of an arterial puncture. In contrast, venous lactate can easily be measured from blood samples obtained via routine peripheral venepuncture. We invest...

microRNA Fine-Tuning of the Germinal Center Response. 

Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. ...

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions. 

Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S. Food and Drug Administration-led SEquence Quality Control project phase2 (SEQC2) effort, we perform...

Recent advances in the pharmacotherapy of pulmonary hypertension: practical considerations. 

Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary vascular remodeling leading to increased vascular resistance. The increased afterload contributes to the development of right ventricular dysfunction and heart failure, which is the leading cause of death among patie...

Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker. 

Spontaneous Coronary Artery Dissection (SCAD) is an important cause of acute coronary syndromes, particularly in young to middle-aged women. Differentiating acute SCAD from coronary atherothrombosis remains a major clinical challenge. A case-control study was used to explore the usefulness of circ...

Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer. 

In the last decade, approaches based on T cells and their immunomodulatory receptors have emerged as a solid improvement in treatments for various types of cancer. However, the roles of these molecules in the therapeutic context of autoimmune and cardiovascular diseases are still relatively unexplo...

Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton. 

Lymphocytes rearrange their shape, membrane receptors and organelles during cognate contacts with antigen-presenting cells (APCs). Activation of T cells by APCs through pMHC-TCR/CD3 interaction (peptide-major histocompatibility complex-T cell receptor/CD3 complexes) involves different steps that le...

Cre mRNA Is Not Transferred by EVs from Endothelial and Adipose-Derived Stromal/Stem Cells during Vascular Network Formation. 

Coculture systems employing adipose tissue-derived mesenchymal stromal/stem cells (ASC) and endothelial cells (EC) represent a widely used technique to model vascularization. Within this system, cell-cell communication is crucial for the achievement of functional vascular network formation. Extrace...

Mitochondrial DNA impact on joint damaged process in a conplastic mouse model after being surgically induced with osteoarthritis. 

It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced OA in conplastic mice in order to evaluate the functional consequences of mtDNA hap...

Caracterización de la mutación R735X de PKP2 en el fenotipo estructural de la Cardiomiopatía Arritmogénica 

La forma genética más prevalente en la cardiomiopatía arritmogénica (ACM, del inglés “arrhythmogenic cardiomyopathy”) es causada por mutaciones en la placofilina-2 (PKP2). La mayoría de las mutaciones en PKP2 descritas en pacientes con ACM, generan proteínas truncadas. Sin embargo, los mecanismos a...

Stress kinases in the regulation of inter-organ communication in obesity comorbidities 

Obesity is characterized by the excessive fat accumulation that develops when energy intake exceeds energy expenditure. Lifestyle changes have increased the prevalence of obesity, which has become a major health problem. In fact, obesity is a well-known risk factor for several chronic diseases, inc...

Dynamics of LDL accumulation leading to atherosclerosis initiation 

Objective – Atherosclerosis is caused by the accumulation of LDL at atherosclerosissusceptible sites. This requires LDLs to pass through the endothelium and be retained in the arterial intima, but which process is rate-limiting and predicts atherosclerosis has remained controversial. To answer this...

Non-randomized comparison between revascularization and deferral for intermediate coronary stenosis with abnormal fractional flow reserve and preserved coronary flow reserve. 

Limited data are available regarding comparative prognosis after percutaneous coronary intervention (PCI) versus deferral of revascularization in patients with intermediate stenosis with abnormal fractional flow reserve (FFR) but preserved coronary flow reserve (CFR). From the International Collabo...

A modular approach toward producing nanotherapeutics targeting the innate immune system. 

Immunotherapies controlling the adaptive immune system are firmly established, but regulating the innate immune system remains much less explored. The intrinsic interactions between nanoparticles and phagocytic myeloid cells make these materials especially suited for engaging the innate immune syst...

Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent. 

The mechanisms through which cells of the host innate immune system distinguish commensal bacteria from pathogens are currently unclear. Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs) expressed by host cells which recognize microbe-associated molecular patterns (MAMP...