Recent Submissions

Can OpenEHR, ISO 13606, and HL7 FHIR Work Together? An Agnostic Approach for the Selection and Application of Electronic Health Record Standards to the Next-Generation Health Data Spaces 

In order to maximize the value of electronic health records (EHRs) for both health care and secondary use, it is necessary for the data to be interoperable and reusable without loss of the original meaning and context, in accordance with the findable, accessible, interoperable, and reusable (FAIR) ...

An Ontology-Based Approach for Consolidating Patient Data Standardized With European Norm/International Organization for Standardization 13606 (EN/ISO 13606) Into Joint Observational Medical Outcomes Partnership (OMOP) Repositories: Description of a Methodology 

Background: To discover new knowledge from data, they must be correct and in a consistent format. OntoCR, a clinical repository developed at Hospital Clínic de Barcelona, uses ontologies to represent clinical knowledge and map locally defined variables to health information standards and common dat...

Co-creation Initiatives in Healthcare in Small Communities 

The uses of technology in public spaces are not new, but now we find new forms of social interactions and practices, socio-spatial representations and relationships. The close relationship between real and virtual worlds also opens up new ways of advancing knowledge. In order to facilitate the impl...

A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases 

The mucosal adaptive immune response is dependent on the production of IgA antibodies and particularly IgA1, yet opportunistic bacteria have evolved mechanisms to specifically block this response by producing IgA1 proteases (IgA1Ps). Our lab was the first to describe the structures of a metal-depen...

Discovering HIV related information by means of association rules and machine learning 

Acquired immunodeficiency syndrome (AIDS) is still one of the main health problems worldwide. It is therefore essential to keep making progress in improving the prognosis and quality of life of affected patients. One way to advance along this pathway is to uncover connections between other disorder...

TransformEHRs: a flexible methodology for building transparent ETL processes for EHR reuse 

Background: During the COVID-19 pandemic, several methodologies were designed for obtaining electronic health record (EHR)-derived datasets for research. These processes are often based on black boxes, on which clinical researchers are unaware of how the data were recorded, extracted, and transform...

Lung Adenocarcinoma Cell Sensitivity to Chemotherapies: A Spotlight on Lipid Droplets and SREBF1 Gene 

To explore the relationship between cancer cell SREBF1 expression, lipid droplets (LDs) formation, and the sensitivity to chemotherapies, we cultured lung adenocarcinoma cells H1299 (with LD) and H1563 (without LD) in a serum-free basal medium (BM) or neutrophil degranulation products containing me...

COVID-19 vaccine hesitancy in Spain and associated factors 

Introduction: The present study explores the reasons of those who have not been vaccinated in the later stage of the vaccine rollout in Spain and its associated determinants. Methods: Cluster and logistic regression analyses were used to assess differences in claimed reasons for vaccine hesitancy i...

Machine learning-based model for prediction of clinical deterioration in hospitalized patients by COVID 19 

Despite the publication of great number of tools to aid decisions in COVID-19 patients, there is a lack of good instruments to predict clinical deterioration. COVID19-Osakidetza is a prospective cohort study recruiting COVID-19 patients. We collected information from baseline to discharge on: socio...

Electromagnetic Assessment of UHF-RFID Devices in Healthcare Environment 

In this work, the evaluation of electromagnetic effect of Ultra High Frequency Radio Frequency Identification (UHF-RFID) passive tags used in the healthcare environment is presented. In order to evaluate exposure levels caused by EM field (865–868 MHz) of UHF-RFID readers, EM measurements in an ane...

Electromagnetic Characterization of UHF-RFID Fixed Reader in Healthcare Centers Related to the Personal and Labor Health 

Hospitals and healthcare centers are experiencing a remarkable implementation of new systems based on wireless communications technologies. Many of these systems provide location services and identi cation of materials, instrumentation and even patients, which promotes the increase of the quality a...

5G Spatial Modeling of Personal RF-EMF Assessment Within Aircrafts Cabin Environments 

Recently, new wireless communication systems within aircrafts cabins have drawn higher atten tion due to the growing demand of passenger services and applications and their corresponding requirements and constraints. In this regard, the fifth generation (5G) of wireless communication becomes an att...

Age-dependent nasal immune responses in non-hospitalized bronchiolitis children 

Bronchiolitis in children is associated with significant rates of morbidity and mortality. Many studies have been performed using samples from hospitalized bronchiolitis patients, but little is known about the immunological responses from infants suffering from mild/moderate bronchiolitis that do n...

The International Academy of Health Sciences Informatics (IAHSI): 2020 Report 

Objectives: To summarize the major activities of the International Academy of Health Sciences Informatics (IAHSI) in the 2020 time period and to welcome its 2020 Class of Fellows. Method: Report from the members of the Academy's Board. Results: Due to the SARS-CoV-2 pandemic, both Plenary meetings ...

Modelling the Influence of the 2.4 GHz Electromagnetic Field on the User of a Wearable Internet of Things (IoT) Device for Monitoring Hazards in the Work Environment 

The aim was to test the hypothesis that there is an insignificant influence on humans from the absorption of an 2.4 GHz electromagnetic field (EMF) emitted by wearable Internet of Things (IoT) devices (using Meandered Inverted-F Antenna (MIFA) for Wi-Fi and Bluetooth technologies) for monitoring ha...

Follow-up with Telemedicine in Early Discharge for COPD Exacerbations: Randomized Clinical Trial (TELEMEDCOPD-Trial) 

The results reported by different studies on telemonitoring in patients with chronic obstructive pulmonary disease (COPD) have been contradictory, without showing clear benefits to date. The objective of this study was to ascertain whether an early discharge and home hospitalization telehealth prog...

Co-creation methodology with Smart technologies in Health and well-being to enable communication between isolated and disperse small communities: a literature review 

Objective: The objective is to determine reported cases of co-creation methodology about the use of smart technologies in public spaces in order to create new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication be...

Semi-supervised incremental learning with few examples for discovering medical association rules 

Background: Association Rules are one of the main ways to represent structural patterns underlying raw data. They represent dependencies between sets of observations contained in the data. The associations established by these rules are very useful in the medical domain, for example in the predicti...

Towards Environmental RF-EMF Assessment of mmWave High-Node Density Complex Heterogeneous Environments 

The densification of multiple wireless communication systems that coexist nowadays, as well as the 5G new generation cellular systems advent towards the millimeter wave (mmWave) frequency range, give rise to complex context-aware scenarios with high-node density heterogeneous networks. In this work...

Hedgehog Signalling Modulates Immune Response and Protects against Experimental Autoimmune Encephalomyelitis. 

The Hedgehog (Hh) pathway is essential for the embryonic development and homeostatic maintenance of many adult tissues and organs. It has also been associated with some functions of the innate and adaptive immune system. However, its involvement in the immune response has not been well determined. ...