Recent Submissions

Building a model of health technology assessment cooperation: lessons learned from EUnetHTA joint action 3 

Objective: The European Network for Health Technology Assessment (EUnetHTA) was established in 2006. During its final project phase (joint action 3 [JA3]), it undertook an activity to define the scientific and technical principles of a model of health technology assessment (HTA) cooperation in Euro...

Impact of environmental and individual factors on COVID-19 mortality in children and adolescents in Mexico: An observational study 

Background: During the Covid-19 pandemic, children and adolescents faced poverty, potentially dying from preventable causes, or missing out essential vaccines. The aim of this study was to assess potential environmental and individual factors associated to COVID-19 mortality in children and adolesc...

Efficacy of a Strategy for Implementing Guidelines for the Control of Cardiovascular Risk in Primary Healthcare 

Background: A number of strategies exist for the implementation of clinical practice guides (CPGs). Aim: To assess the efficacy of implementing a cardiovascular risk CPG based on an educational method involving opinion leaders, and the habitual method of dissemination among primary healthcare teams...

Short- and Long-Term Implications of Human Milk Microbiota on Maternal and Child Health 

Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, ...

Patient-reported outcome measures for knowledge transfer and behaviour modification interventions in type 2 diabetes-the INDICA study: a multiarm cluster randomised controlled trial 

Objective: This study assesses the effectiveness of different interventions of knowledge transfer and behaviour modification to improve type 2 diabetes mellitus patients' (T2DM) reported outcomes measures (PROMs) in the long-term. Design: open, community-based pragmatic, multicentre, controlled tri...

Efficacy of a strategy for implementing a guideline for the control of cardiovascular risk in a primary healthcare setting: the SIRVA2 study a controlled, blinded community intervention trial randomised by clusters 

Abstract This work describes the methodology used to assess a strategy for implementing clinical practice guidelines (CPG) for cardiovascular risk control in a health area of Madrid. Background: The results on clinical practice of introducing CPGs have been little studied in Spain. The strategy ...

Rapid and simultaneous determination of histidine metabolism intermediates in human and mouse microbiota and biomatrices 

Histidine metabolism is a key pathway physiologically involved in satiety, recognition memory, skin, and neural protection and allergic diseases. Microbiologically-produced imidazole propionate induces type II diabetes and interferes with glucose lowering drugs. Despite their determinant health imp...

Effect of a Surgical Care Bundle on the Incidence of Surgical Site Infection in Colorectal Surgery: A Quasi-Experimental Intervention 

Background: Surgical site infections (SSI) have an important impact on morbidity and mortality. Objective: This study, therefore, sought to assess the effect of a surgical care bundle on the incidence of SSI in colorectal surgery. Methods: We conducted a quasi-experimental intervention study with r...

Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan 

Familial British and Danish dementias (FBD and FDD) share striking neuropathological similarities with Alzheimer's disease (AD), including intraneuronal neurofibrillary tangles as well as parenchymal and vascular amyloid deposits. Multiple amyloid associated proteins with still controversial role i...

Systematic review of the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion for the treatment of refractory chronic cluster headache 

[EN] Introduction: This study aimed to assess the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion (SPG) in the treatment of refractory chronic cluster headache. Development: Various medical databases were used to perform a systematic review of the scientific l...

Efecto de un Plan de Mejora de Calidad y Seguridad Clínica en la incidencia de infección de sitio quirúrgico en apendicectomía. Estudio cuasi-experimental 

[ES] Objetivo: Las infecciones de sitio quirúrgico se pueden evitar y los programas de control basados en paquetes de medidas preventivas son eficaces para reducir su incidencia. El objetivo de este estudio fue evaluar el efecto de un Plan de Mejora de Calidad y Seguridad Clínica del paciente inter...

Infant Gut Microbiota Associated with Fine Motor Skills 

Background: During early life, dynamic gut colonization and brain development co-occur with potential cross-talk mechanisms affecting behaviour. Methods: We used 16S rRNA gene sequencing to examine the associations between gut microbiota and neurodevelopmental outcomes assessed by the Bayley Scales...

Effectiveness and safety of glimepiride and iDPP4, associated with metformin in second line pharmacotherapy of type 2 diabetes mellitus: systematic review and meta-analysis 

Objective: Our review analyses the studies that have specifically compared the association iDPP4/metformin with glimepiride/metformin, both in second line pharmacotherapy of type 2 diabetes mellitus (DM2). Methods: Systematic literature review with a meta-analysis of clinical trials comparing glime...

Design and validation of an oral health questionnaire for preoperative anaesthetic evaluation 

[EN] Background and objectives: Dental injuries incurred during endotracheal intubation are more frequent in patients with previous oral pathology. The study objectives were to develop an oral health questionnaire for preanaesthesia evaluation, easy to apply for personnel without special dental tra...

Los cuidados en la configuración de la identidad profesional de la enfermería española 

[ES] La enfermería española expresa recurrentemente su malestar por su escaso reconocimiento social pese a que diferentes encuestas muestran una alta valoración de la profesión por parte de la sociedad española. Esta aparente contradicción es interpretable a partir del proceso, iniciado en la d...

Análisis cualitativo de las innovaciones organizativas en hospitales públicos españoles 

[ES] Conocer la opinión de directivos y clínicos de hospitales públicos sobre los institutos clínicos. dio cualitativo que trata de responder a preguntas realizadas a gerentes y clínicos sobre las innovaciones organizativas que afectan a más de un nivel de intervención de la gestión sanitaria. ...

Comunicación científica e innovación tecnológica en la primera Cruz Roja, 1863-1876 

[ES] Los primeros años del movimiento internacional de Cruz Roja coincidieron con grandes cambios tecnológicos en la medicina de guerra. Las peculiaridades organizativas de la Asociación Internacional de Socorro a los Soldados Heridos en Campaña, impulsada por el Comité de Ginebra y los comités nac...

Percepciones de gestores de salud y facilitadores de la estrategia Atención Integrada a las Enfermedades Prevalentes (AIEPI) en una zona del Noreste de Brasil y Perú 

[ES] El objetivo del estudio fue explorar las percepciones sobre la estrategia de Atención Integrada a las Enfermedades Prevalentes en la Infancia (AIEPI) de gestores de salud y facilitadores de la estrategia. Se realizó una investigación de tipo cualitativo mediante entrevistas semiestructuradas. ...

Effectiveness of natriuretic peptide-guided treatment of chronic heart failure. A meta-analysis. 

[EN] To evaluate the efficacy of natriuretic peptide (NP)-guided therapy compared to clinically-guided therapy in reducing mortality and hospital admissions in chronic heart failure (HF) patients. Randomised clinical trials (RCT) were selected through a systematic review. Four meta-analyses were ...