La Agencia de Evaluación de Tecnologías Sanitarias se crea dentro del Instituto de Salud Carlos III (ISCIII) mediante el R.D. 1415/1994, de 25 de junio, para atender las necesidades consultivas del Sistema Nacional de Salud (SNS) en relación con la definición de su Política de Prestaciones Sanitarias, en la línea imperante en los Sistemas Sanitarios socialmente avanzados. La AETS atiende las necesidades de información y evidencia científica del SNS en relación con la definición de su política de prestaciones sanitarias y la mejora de la calidad y eficiencia. Desde el año 2012, gran parte de las funciones de la AETS quedan enmarcadas en la "Red Española de Agencias de Evaluación de Tecnologías Sanitarias y Prestaciones del Sistema Nacional de Salud" (RedETS). La misión de RedETS es generar, difundir y facilitar la implementación de información destinada a los decisores del SNS, contribuyendo a incrementar la calidad, equidad, eficiencia y cohesión en el sistema. RedETS pretende fundamentar la toma de decisiones sobre incorporación, condiciones de financiación/desinversión, y uso apropiado de las tecnologías sanitarias, con el fin de promover la equidad y sostenibilidad del SNS.

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Recent trends of invasive mechanical ventilation in older adults: a nationwide population-based study 

Background: Critical care demand for older people is increasing. However, there is scarce population-based information about the use of life-support measures such as invasive mechanical ventilation (IMV) in this population segment. Objective: To examine the characteristics and recent trends of IMV ...

Safety of balloon kyphoplasty in the treatment of osteoporotic vertebral compression fractures in Europe: a meta-analysis of randomized controlled trials 

Purpose: The study aims to evaluate the safety of balloon kyphoplasty in the treatment of painful osteoporotic vertebral compression fractures in Europe. Methods: Systematic review of the literature, until September 2013, and meta-analysis of randomized controlled trials performed in Europe assessi...

Characteristics, incidence and temporal trends of sepsis in elderly patients undergoing surgery 

Background: Despite increasing rates of surgery in the elderly, there is limited population-based information on sepsis in this age group. This study aimed to characterize the epidemiology and national trends of sepsis among elderly patients undergoing surgery in Spain. Methods: This population-bas...

Hospital admissions due to physical disease in people with schizophrenia: a national population-based study 

Objectives: To examine nonpsychiatric hospitalizations in people with schizophrenia and to describe the epidemiological features of these admissions. Methods: We analyzed the 2000-2004 Spanish National Hospital Discharge Registry, identified records coded for schizophrenia (295.xx), selected admiss...

Outcomes of new quality standards of follitropin alfa on ovarian stimulation: meta-analysis of previous studies 

Background: Human follicle-stimulating hormone (hFSH; follitropin alfa) can be employed therapeutically to induce ovarian follicular development in assisted reproduction treatments. Current recombinant hFSH (r-hFSH) preparations available for clinical use are labeled either in terms of the bioactiv...

Hospitalised osteoporotic vertebral fractures in Spain: analysis of the national hospital discharge registry 

This population-based study reveals clinical and epidemiologic characteristics of hospitalised osteoporosis-related vertebral fractures and indicates an association with a substantial hospital burden in Spain. These data provide a basis for assessing the impact of these fractures on the Spanish hea...

Efficacy and safety of balloon kyphoplasty in the treatment of vertebral compression fractures: a systematic review 

The aim of this study is to evaluate the efficacy and safety of balloon kyphoplasty (BK) in the management of vertebral compression fractures (VCFs). This study is based on a systematic review of the literature (until October 2004) and meta-analysis of clinical studies assessing the efficacy and sa...

Lamivudine and Entecavir for Acute Hepatitis B: A Systematic Review and Meta-Analysis 

Background: Acute hepatitis B infection is associated with severe liver disease and chronic sequelae in some cases. The purpose of this review was to determine the efficacy of nucleoside analogues (NA) (lamivudine versus entecavir) compared to placebo or no intervention for treating acute primary H...

Contribution of psychoactive substance use and other environmental factors to adolescent pregnancies in Mexico 

Introduction: Mexico has the highest prevalence of adolescent pregnancies among all the member countries of the Organization for Economic Co-operation and Development (OECD) with a fertility rate of 70.6 births for every 1000 women aged 15–19 years. This study explored the associations between psyc...

Effect of prevalence of alcohol consumption and tobacco use in Mexican municipalities on early childhood development 

[EN] One of the most critical time periods in childhood is from birth to five years of age. Children exposed to alcohol and/or tobacco via family members and neighborhood are at risk for childhood developmental delays. This study evaluated the association of early childhood development with the pre...

Telemedicine for neurological diseases: A systematic review and meta-analysis 

Background: To systematically review the effectiveness and safety of telemedicine combined with usual care (in-person visits) compared to usual care for the therapeutic management and follow-up assessment of neurologic diseases. Methods: The electronic databases MEDLINE, EMBASE, WOS, and Cochrane C...

Radiocirugía giroscópica para el tratamiento de lesiones cerebrales, y del área de cabeza y cuello 

La radiocirugía estereotáctica (SRS, del inglés stereotactic radiosurgery) es una forma de radioterapia no invasiva, no quirúrgica, de gran precisión, indicada principalmente para el tratamiento de lesiones cerebrales o intracraneales. La SRS cerebral permite la administración, en una única sesión,...

Análisis coste-utilidad del cribado neonatal universal de cardiopatías congénitas críticas basado en pulsioximetría en España 

La detección de defectos cardíacos congénitos críticos (DCCC) se inicia durante la gestación con la realización de ecografías prenatales y continúa en las primeras horas tras el nacimiento con la realización de exploración física y revisión del historial clínico, y de forma cada vez más extendida m...

Real-world persistence of initial targeted therapy strategy in monotherapy versus combination therapy in patients with chronic inflammatory arthritis 

Objective: The persistence of biologic (b) and targeted synthetic (ts) disease-modifying antirheumatic drugs(DMARDs) in monotherapy versus in combination with conventional synthetic (cs) DMARDs is still a controversial topic in rheumatic diseases. To clarify this issue, the retention of the initial...

Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study 

Objective: To investigate the influence of COVID-19 vaccination on disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients under targeted therapies. Patients and methods: 1765 vaccinated patients COVID-19, 1178 (66.7%) with RA and 587 (33.3%) with PsA from the COVID-19 ...

Detection of the Frail Elderly at Risk of Postoperative Sepsis. 

With the increase in the elderly population, surgery in aged patients is seeing an exponential increase. In this population, sepsis is a major concern for perioperative care, especially in older and frail patients. We aim to investigate the incidence of sepsis in elderly patients receiving diverse ...

Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry 

Background: The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthritis in remission. Methods: An observational retrospective study from the BIOB...

Ethical, Legal, Organisational and Social Issues of Teleneurology: A Scoping Review 

Background: Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. Teleneurology (TN) allows neurology to be applied when the doctor and patient are not present in the same place, and sometimes not at the same time. In February 2021, the Spanish ...

Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance 

An evidence-based approach is considered the gold standard for health decision-making. Sometimes, a guideline panel might judge the certainty that the desirable effects of an intervention clearly outweigh its undesirable effects as high, but the body of supportive evidence is indirect. In such case...

Incidence and prevalence of multiple sclerosis in Spain: a systematic review 

[EN] Introduction: Greater understanding of the prevalence and incidence of multiple sclerosis in Spain and their temporal trends is necessary to improve the allocation of healthcare resources and to study aetiological factors. Methods: We performed a systematic search of the MedLine database and r...