El Centro Nacional de Sanidad Ambiental (CNSA) es el órgano científico-técnico del Instituto de Salud Carlos III, especializado en los aspectos sanitarios de los problemas derivados de la contaminación medioambiental. Su finalidad primordial es la caracterización del riesgo potencial ante contaminantes ambientales a los que está expuesta la población. Fue creado mediante Decreto 252/1974, de 25 de enero y posteriormente, adscrito al Instituto de Salud Carlos III (Ley 14/1986). Actualmente trabajan en el CNSA más de 100 personas con alta cualificación técnica y sus laboratorios cuentan con una extensión de más de 3 000 m2, dotados con instrumentación de última tecnología. Funciona bajo un sistema de calidad UNE-EN ISO/IEC 17025 y está acreditado por la Entidad Nacional de Acreditación (ENAC) para 186 ensayos, distribuidos en las distintas unidades funcionales: Contaminación Atmosférica, Contaminación Hídrica y Microbiología Ambiental, Toxicología Ambiental y Radioprotección.

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Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring 

Although the exposure assessment of chemicals of emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and the development of highly sophisticated analytical instruments, the lack of standardisation and harmonisation of analytical workflows and ...

Challenges to Evidence Synthesis and Identification of Data Gaps in Human Biomonitoring. 

The increasing number of human biomonitoring (HBM) studies undertaken in recent decades has brought to light the need to harmonise procedures along all phases of the study, including sampling, data collection and analytical methods to allow data comparability. The first steps towards harmonisation ...

Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring 

Although the exposure assessment of chemicals of emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and the development of highly sophisticated analytical instruments, the lack of standardisation and harmonisation of analytical workflows and ...

Interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for cadmium in urine and blood: Results from the HBM4EU project. 

Human biomonitoring (HBM) of cadmium is essential to assess and prevent toxic exposure. Generally, low cadmium levels in urine and blood of the general population place particularly high demands on quality assurance and control measures (QA/QC) for cadmium determination. One of the aims of the HBM4...

Aspectos prácticos de la fase preanalítica del estudio de biovigilancia BIOAMBIENT.ES 

[ES] Entre marzo de 2009 y julio de 2010 se desarrolló el trabajo de campo de BIOAMBIENT.ES, un estudio de biovigilancia de contaminantes ambientales en humanos de cobertura nacional. Esta nota pretende mostrar las tareas desarrolladas antes del comienzo del trabajo de campo con el fin de asegurar...

Learning from previous work and finding synergies in the domains of public and environmental health: EU-funded projects BRIDGE Health and HBM4EU. 

During the last decade, the European Union initiated several projects in the domains of public and environmental health. Within this framework, BRIDGE Health (Bridging Information and Data Generation for Evidence-based Health policy and Research) and HBM4EU (European human biomonitoring initiative)...

A Phased Approach for preparation and organization of human biomonitoring studies. 

Human biomonitoring (HBM) studies like other epidemiological studies are costly and time-consuming. They require the administration of questionnaires and collection of biological samples, putting substantial burden on the participants which may result in low participation rates. The growing importa...

Biomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative. 

The major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DI...

Human biomonitoring in health risk assessment in Europe: Current practices and recommendations for the future. 

Human biomonitoring (HBM) is an important tool to survey the internal exposure of humans which represents the real life chemical body burden to chemicals and/or their metabolites. It results from total exposure to chemical substances from different sources and via different routes. These substances...

DEMOCOPHES España y su contribución a la armonización de la biovigilancia humana en Europa 

Objetivo: contribuir a la armonización europea de la biovigilancia en humanos (proyecto DEMOCOPHES) demostrando la utilidad de los estudios de biovigilancia para valorar la influencia de la dieta y los estilos de vida como vía de exposición a contaminantes ambientales.Métodos: se adaptó el protocol...

Towards Harmonized Biobanking for Biomonitoring: A Comparison of Human Biomonitoring-Related and Clinical Biorepositories. 

Human biomonitoring (HBM) depends on high-quality human samples to identify status and trends in exposure and ensure comparability of results. In this context, much effort has been put into the development of standardized processes and quality assurance for sampling and chemical analysis, while eff...

Prevalence of intestinal parasite infections in stray and farm dogs from Spain. 

Dogs play a potential role as reservoirs for zoonotic parasites, being especially problematic uncontrolled dog populations such as stray and farm dogs with access to populated areas. In order to investigate the prevalence of canine intestinal parasites in at-risk dog populations, we tested a total ...

Particle-associated polycyclic aromatic hydrocarbons in a representative urban location (indoor-outdoor) from South Europe: Assessment of potential sources and cancer risk to humans 

PM10 -bound polycyclic aromatic hydrocarbons (PAHs) levels were monitored at urban locations (outdoor/indoor) within the city of Madrid between May 2017 and April 2018. Fourteen PAH congeners were measured, potential emission sources were identified as were potential carcinogenic risks. The ΣPAHs a...

Mercury levels in blood, urine and hair in a nation-wide sample of Spanish adults 

Mercury (Hg) is among the top 10 environmental chemicals of major public health concern (WHO). The Minamata Convention on Mercury (United Nations Environment Program, 2017), commits signing countries to control anthropogenic mercury emissions and reduce human exposure. Human biomonitoring (HBM) pro...

Organochlorinated pesticides levels in a representative sample of the Spanish adult population: The Bioambient.es project 

Organochlorinated pesticides (OCPs) were measured in a representative sample of Spanish adults within the Bioambient.es project, a nationwide human biomonitoring program promoted by Spanish Ministry of Agriculture, Food and Environment. The objective of Bioambient.es is to establish reference level...

Malaria Household Knowledge and Behavior in Equatorial Guinea: Lessons to Be Learned 

Equatorial Guinea is a small country located in the Gulf of Guinea and consisting of an insular region and a mainland region. The whole country is categorized as a malaria high transmission area, with more than 1 case per 1000 population, and more than 80% of the cases due to P. falciparum [1]. Now...

Short-Term Effects of Ozone on Mortality: Comparative Analysis of Urban and Suburban Zones in Madrid (Spain) 

A large number of papers published in the last decades are related to the effect of ozone exposure on mortality worldwide. Several studies have been performed to investigate the effect of ozone on mortality in Madrid (Spain), but the findings of these local reports were focused only on the Madrid c...

Dielectric Characterization Of The Yeast Cell Budding Cycle 

We combine experimental electrorotation data and the numerical analysis of the electrorotation chamber and cell to electrically characterize the Saccharomyces cerevisiae yeast budding cell cycle and to obtain the electrical parameters of the cell. To model the yeast cell we use spherical and double...

Variability of carbonaceous aerosols in remote, rural, urban and industrial environments in Spain: implications for air quality policy 

Abstract. We interpret here the variability of levels of carbonaceous aerosols based on a 12 yr database from 78 monitoring stations across Spain specially compiled for this article. Data did not evidence any spatial trends of carbonaceous aerosols across the country. Conversely, results show marke...

Phenomenology of summer ozone episodes over the Madrid Metropolitan Area, central Spain 

Various studies have reported that the photochemical nucleation of new ultrafine particles (UFPs) in urban environments within high insolation regions occurs simultaneously with high ground ozone (O3) levels. In this work, we evaluate the atmospheric dynamics leading to summer O3 episodes in the Ma...