El Centro Nacional de Sanidad Ambiental (CNSA) es el órgano científico-técnico del Instituto de Salud Carlos III, especializado en los aspectos sanitarios de los problemas derivados de la contaminación medioambiental. Su finalidad primordial es la caracterización del riesgo potencial ante contaminantes ambientales a los que está expuesta la población. Fue creado mediante Decreto 252/1974, de 25 de enero y posteriormente, adscrito al Instituto de Salud Carlos III (Ley 14/1986). Actualmente trabajan en el CNSA más de 100 personas con alta cualificación técnica y sus laboratorios cuentan con una extensión de más de 3 000 m2, dotados con instrumentación de última tecnología. Funciona bajo un sistema de calidad UNE-EN ISO/IEC 17025 y está acreditado por la Entidad Nacional de Acreditación (ENAC) para 186 ensayos, distribuidos en las distintas unidades funcionales: Contaminación Atmosférica, Contaminación Hídrica y Microbiología Ambiental, Toxicología Ambiental y Radioprotección.

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Methylmercury Risk Assessment Based on European Human Biomonitoring Data 

A risk assessment (RA) was conducted to estimate the risk associated with methylmercury (MeHg) exposure of vulnerable European populations, using Human Biomonitoring (HBM) data. This RA was performed integrating published data from European HBM surveys and earlier EFSA approaches (EFSA 2012). Child...

Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children. 

Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM exposure data were collected from aligned studies at five sampling sites distributed over Europe (studies: SLO CRP (SI); ORGANIKO (CY); GerES V-sub (DE); 3XG (BE); ESTEBAN (FR)). Median Gly conc...

A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data 

Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall p...

Mortality due to COVID-19 in Spain and its association with environmental factors and determinants of health 

The objective of this study was to identify which air pollutants, atmospheric variables and health determinants could influence COVID-19 mortality in Spain. This study used information from 41 of the 52 provinces in Spain (from Feb. 1, to May 31, 2021). Generalized Linear Models (GLM) with Poisson ...

Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants 

Human biomonitoring has become a pivotal tool for supporting chemicals' policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern and to evaluate the success of chemical policies. Europe has launched the ambitious REACH program...

Cambio climático. Perspectivas futuras 

[ES] El presente artículo pretende ofrecer una visión global referente al cambio climático en relación a aspectos tales como su relación con los gases de efecto invernadero, efectos sobre el medioambiente, ser humano, economía, así como las posibles consecuencias futuras y la importancia en la toma...

Outdoor, indoor and personal distribution of BTEX in pregnant women from two areas in Spain - Preliminary results from the INMA project 

Volatile organic compounds (VOCs), which are habitually found in both outdoor and indoor environments, may represent a significant health risk. In this context, pregnancy is a critical period since foetuses are more vulnerable than adults to exposure to toxic compounds. The objective of this study ...

Health-related quality of life (HRQoL) in a population at risk of type 2 diabetes: a cross-sectional study in two Latin American cities 

Purpose: The purpose of this study was to describe the health-related quality of life (HRQoL) characteristics in a population at risk of developing type 2 diabetes in Barranquilla and Bogotá, Colombia. Methods: A cross-sectional study with 1135 participants older than 30 years-of-age recruited in B...

Proficiency and Interlaboratory Variability in the Determination of Phthalate and DINCH Biomarkers in Human Urine: Results from the HBM4EU Project 

A quality assurance/quality control program was implemented in the framework of the EU project HBM4EU to assess and improve the comparability of biomarker analysis and to build a network of competent laboratories. Four rounds of proficiency tests were organized for 15 phthalate and two DINCH urinar...

European interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for the analysis of bisphenol A, S and F in human urine: Results from the HBM4EU project 

The Human Biomonitoring for Europe initiative (HBM4EU) aims to study the exposure of citizens to chemicals and potentially associated health effects. One objective of this project has been to build a network of laboratories able to answer to the requirements of European human biomonitoring studies....

Critical review of analytical methods for the determination of flame retardants in human matrices 

Human biomonitoring is a powerful approach in assessing exposure to environmental pollutants. Flame retardants (FRs) are of particular concern due to their wide distribution in the environment and adverse health effects. This article reviews studies published in 2009-2020 on the chemical analysis o...

User-Centred Design of a Final Results Report for Participants in Multi-Sensor Personal Air Pollution Exposure Monitoring Campaigns 

Using low-cost portable air quality (AQ) monitoring devices is a growing trend in personal exposure studies, enabling a higher spatio-temporal resolution and identifying acute exposure to high concentrations. Comprehension of the results by participants is not guaranteed in exposure studies. Howeve...

Interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs) for flame retardant analysis in biological matrices: Results from the HBM4EU project 

The European Human Biomonitoring Initiative (HBM4EU) is coordinating and advancing human biomonitoring (HBM). For this purpose, a network of laboratories delivering reliable analytical data on human exposure is fundamental. The analytical comparability and accuracy of laboratories analysing flame r...

Harmonization and Visualization of Data from a Transnational Multi-Sensor Personal Exposure Campaign 

Use of a multi-sensor approach can provide citizens with holistic insights into the air quality of their immediate surroundings and their personal exposure to urban stressors. Our work, as part of the ICARUS H2020 project, which included over 600 participants from seven European cities, discusses t...

Mercury Levels in Feathers of Penguins from the Antarctic Peninsula Area: Geographical and Inter-Specific Differences 

Polar regions, symbols of wilderness, have been identified as potential sinks of mercury coming from natural and anthropogenic sources at lower latitudes. Changes in ice coverage currently occurring in some areas such as the Antarctic Peninsula could enhance these phenomena and their impacts on loc...

HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium 

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and deci...

HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity - The HBM4EU survey 

As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This survey builds on existing HBM capacity in Europe by aligning national or regional HBM studies. The survey targets 3 age groups (i) children aged 6-11 years, (ii) t...

Communication in a Human biomonitoring study: Focus group work, public engagement and lessons learnt in 17 European countries 

A communication strategy was developed by The Consortium to Perform Human Biomonitoring on a European Scale (COPHES), as part of its objectives to develop a framework and protocols to enable the collection of comparable human biomonitoring data throughout Europe. The framework and protocols were te...

Exposure determinants of cadmium in European mothers and their children 

The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and d...

NPAHs and OPAHs in the atmosphere of two central European cities: Seasonality, urban-to-background gradients, cancer risks and gas-to-particle partitioning 

Derivatives of polycyclic aromatic hydrocarbons (PAHs) such as nitrated- and oxygenated-PAHs (NPAHs and OPAHs) could be even more toxic and harmful for the environment and humans than PAHs. We assessed the spatial and seasonal variations of NPAHs and OPAHs atmospheric levels, their cancer risks and...