Artículos, contribuciones a congresos, datos de investigación, libros, capítulos de libro, patentes, tesis y trabajos de investigación.

Sub-communities within this community

  • ISCIII [2899]

    Instituto de Salud Carlos III
  • CNIC [1064]

    Centro Nacional de Investigaciones Cardiovasculares
  • CNIO [429]

    Centro Nacional de Investigaciones Oncológicas

Recent Submissions

Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides 

Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1) in human clinical trials. In vitro, ex vivo, and in vivo models must be optimized, considering the knowl...

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019 

Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in...

Ocular surface health of the Finnish elderly population 

Purpose: The aim of this study was to describe the clinical ocular surface characteristics in a population-based sample of Finnish elderly people. Methods: This cross-sectional study included 601 subjects (335 females, 266 males) born between the years 1933-1956 and living in Savitaipale, Finland. ...

Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study) 

Purpose: The variation in breast cancer (BC)-risk factor associations between screen-detected (SD) and non-screen-detected (NSD) tumors has been poorly studied, despite the interest of this aspect in risk assessment and prevention. This study analyzes the differences in breast cancer-risk factor as...

Weather Variables Associated with Spore Dispersal of Lecanosticta acicola Causing Pine Needle Blight in Northern Spain 

In the last decade, the impact of needle blight fungal pathogens on the health status of forests in northern Spain has marked a turning point in forest production systems based on Pinus radiata species. Dothistroma needle blight caused by Dothistroma septosporum and D. pini, and brown spot needle b...

Lecciones y retos tras dos años de pandemia. La opinión autorizada - Cristóbal Belda 

El informe “Lecciones y retos tras dos años de pandemia” analiza la respuesta de la sociedad española ante la enfermedad COVID-19 desde tres ámbitos: la investigación, las empresas y la ciudadanía en general. Recoge además las reflexiones de 19 expertos y expertas y 8 empresas que hacen balance de ...

Everyday Lives of Middle-Aged Persons with Multimorbidity: A Mixed Methods Systematic Review 

The healthcare burden of patients with multimorbidity may negatively affect their family lives, leisure time and professional activities. This mixed methods systematic review synthesizes studies to assess how multimorbidity affects the everyday lives of middle-aged persons, and identifies skills an...

HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization 

Gender-specific consequences after HCV eradication are unexplored. MicroRNAs (miRNAs) play a crucial role in the immune response against viral infections. However, few have highlighted miRNA role in sex-biased disease or therapy response. We aim to assess gender differences reflected in the miRNA e...

When to change treatment of acute invasive aspergillosis: an expert viewpoint 

Invasive aspergillosis (IA) is an acute infection affecting patients who are immunocompromised, as a result of receiving chemotherapy for malignancy, or immunosuppressant agents for transplantation or autoimmune disease. Whilst criteria exist to define the probability of infection for clinical tria...

Evolución de la mortalidad atribuible al alcohol en España según edad, sexo, causa de muerte y tipo de bebedor (2001-2017) 

[ES] En España no hay estimaciones recientes de la mortalidad atribuible a alcohol con datos de consumo de alcohol españoles. El objetivo es estimarla y conocer la evolución entre 2001 y 2017 en personas ≥15 años, según sexo, edad, periodo, causa de muerte y tipo de bebedor. Se utilizó el enfoque c...

Metodología utilizada para estimar la mortalidad atribuible a alcohol en España, 2001-2017 

[ES] El objetivo es describir y discutir los métodos y asunciones para estimar la mortalidad atribuible a alcohol en España en 2001-2017. Se estimó el nº medio anual de muertes atribuibles a alcohol (MAAs) basándose en 19 grupos de causas de muerte relacionadas con alcohol (18 parcialmente atribuib...

The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations 

Introduction: The 2018 Global Meningococcal Initiative (GMI) meeting focused on evolving invasive meningococcal disease (IMD) epidemiology, surveillance, and protection strategies worldwide, with emphasis on emerging antibiotic resistance and protection of high-risk populations. The GMI is comprise...

Do agri-food market incentives improve food security and nutrition indicators? a microsimulation evaluation for Kenya 

The sustainable development goal #2 aims at ending hunger and malnutrition by 2030. Given the numbers of food insecure and malnourished people on the rise, the heterogeneity of nutritional statuses and needs, and the even worse context of COVID-19 pandemic, this has become an urgent challenge for f...

Postlaunch evidence-generation studies for medical devices in Spain: the RedETS approach to integrate real-world evidence into decision making 

The Monitoring Studies (MS) program, the approach developed by RedETS to generate postlaunch real-world evidence (RWE), is intended to complement and enhance the conventional health technology assessment process to support health policy decision making in Spain, besides informing other interested s...

Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018 

New circulating Enterovirus (EV) strains often emerge through recombination. Upsurges of recombinant non-polio enteroviruses (NPEVs) associated with neurologic manifestations such as EVA71 or Echovirus 30 (E30) are a growing public health concern in Europe. Only a few complete genomes of EVs circul...

Ratio of the Dead to Wounded (D/W) Indicators and Associated Factors in Major Earthquakes of America from 1960 to 2011 

The paper presented deals with the casualties, mortality, and morbidity occurred during the major earthquakes of America during a period of 51 years. The work provides statistical evidence that the deaths/wounded (D/W) ratio used for many agencies in the planning of the preparation and response act...

Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program 

Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of...

Advanced Parkinson's or "complex phase" Parkinson's disease? Re-evaluation is needed 

Holistic management of Parkinson's disease, now recognised as a combined motor and nonmotor disorder, remains a key unmet need. Such management needs relatively accurate definition of the various stages of Parkinson's from early untreated to late palliative as each stage calls for personalised ther...

Rating Scales for Movement Disorders With Sleep Disturbances: A Narrative Review 

Introduction: In recent years, a wide variety of rating scales and questionnaires for movement disorders have been developed and published, making reviews on their contents, and attributes convenient for the potential users. Sleep disorders are frequently present in movement disorders, and some mov...