Artículos, contribuciones a congresos, datos de investigación, libros, capítulos de libro, patentes, tesis y trabajos de investigación.

Sub-communities within this community

  • ISCIII [2916]

    Instituto de Salud Carlos III
  • CNIC [1065]

    Centro Nacional de Investigaciones Cardiovasculares
  • CNIO [429]

    Centro Nacional de Investigaciones Oncológicas

Recent Submissions

Living with chronic illness scale in Parkinson's disease: Longitudinal metric properties and meaningful change 

Aim: To analyze the responsiveness and interpretability of the Living with Chronic Illness Scale in patients with Parkinson’s disease (LW-CI-PD). Methods: Longitudinal, international study, with a convenience sample of 153 PD Spanish and Latin-American patients assessed at baseline and one year lat...

Transcriptomic Evidence of the Immune Response Activation in Individuals With Limb Girdle Muscular Dystrophy Dominant 2 (LGMDD2) Contributes to Resistance to HIV-1 Infection 

LGMDD2 is a rare form of muscular dystrophy characterized by one of the three heterozygous deletions described within the TNPO3 gene that result in the addition of a 15-amino acid tail in the C-terminus.TNPO3 is involved in the nuclear import of splicing factors and acts as a host cofactor for HIV-...

Assessing the effect of non-pharmaceutical interventions on COVID-19 transmission in Spain, 30 August 2020 to 31 January 2021 

Background: After a national lockdown during the first wave of the COVID-19 pandemic in Spain, regional governments implemented different non-pharmaceutical interventions (NPIs) during the second wave. Aim: To analyse which implemented NPIs significantly impacted effective reproduction number (Rt) ...

Diagnostic Process in Rare Diseases: Determinants Associated with Diagnostic Delay 

Many people living with rare disease (RD) report a difficult diagnostic process from the symptom onset until they obtain the definitive diagnosis. The aim of this study was thus to ascertain the diagnostic process in RDs, and explore the determinants related with having to wait for more than one ye...

Medio siglo de cribado neonatal en España: evolución de los aspectos éticos, legales y soliales (AELS). Parte II, marco legal 

[ES] El cribado neonatal es una actuación sanitaria regulada específicamente en nuestra legislación. El ordenamiento jurídico establece que el cribado sanitario es una actuación de salud pública, enfocada a la prevención de la salud de la sociedad en general y, a la vez, una prestación sanitaria, e...

Co-creation methodology with Smart technologies in Health and well-being to enable communication between isolated and disperse small communities: a literature review 

Objective: The objective is to determine reported cases of co-creation methodology about the use of smart technologies in public spaces in order to create new forms of social interactions and practices, which in turn creates new socio-spatial relations and promotes interactions and communication be...

Test combination to detect latent Leishmania infection: a prevalence study in a newly endemic area for L. infantum, northeastern Italy [Dataset] 

Background: Most people infected with Leishmania remain asymptomatic, which is a common element that may promote the resurgence of clinically evident leishmaniasis in individuals with impaired cell-mediated immune responses. Unfortunately, there is no universally accepted assay to identify asymptom...

Educational Gradients in Drinking Amount and Heavy Episodic Drinking among Working-Age Men and Women in Spain 

Alcohol-related harm decreases as socioeconomic position increases, although sometimes the opposite happens with alcohol intake. The objective was to know the educational gradient in monthly measures of drinking amount and heavy episodic drinking (HED) among people aged 25-64 years in Spain from 19...

Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment 

We have observed a drug-tolerant/persister state in a human glioblastoma (GBM) cell line after exposure to temozolomide, the standard-of-care chemotherapeutic agent for GBM. We used a multicolor lentiviral genetic barcode labeling to follow cell population evolution during temozolomide treatment. W...

Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides 

Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1) in human clinical trials. In vitro, ex vivo, and in vivo models must be optimized, considering the knowl...

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019 

Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in...

Ocular surface health of the Finnish elderly population 

Purpose: The aim of this study was to describe the clinical ocular surface characteristics in a population-based sample of Finnish elderly people. Methods: This cross-sectional study included 601 subjects (335 females, 266 males) born between the years 1933-1956 and living in Savitaipale, Finland. ...

Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study) 

Purpose: The variation in breast cancer (BC)-risk factor associations between screen-detected (SD) and non-screen-detected (NSD) tumors has been poorly studied, despite the interest of this aspect in risk assessment and prevention. This study analyzes the differences in breast cancer-risk factor as...

Weather Variables Associated with Spore Dispersal of Lecanosticta acicola Causing Pine Needle Blight in Northern Spain 

In the last decade, the impact of needle blight fungal pathogens on the health status of forests in northern Spain has marked a turning point in forest production systems based on Pinus radiata species. Dothistroma needle blight caused by Dothistroma septosporum and D. pini, and brown spot needle b...

Lecciones y retos tras dos años de pandemia. La opinión autorizada - Cristóbal Belda 

El informe “Lecciones y retos tras dos años de pandemia” analiza la respuesta de la sociedad española ante la enfermedad COVID-19 desde tres ámbitos: la investigación, las empresas y la ciudadanía en general. Recoge además las reflexiones de 19 expertos y expertas y 8 empresas que hacen balance de ...

Everyday Lives of Middle-Aged Persons with Multimorbidity: A Mixed Methods Systematic Review 

The healthcare burden of patients with multimorbidity may negatively affect their family lives, leisure time and professional activities. This mixed methods systematic review synthesizes studies to assess how multimorbidity affects the everyday lives of middle-aged persons, and identifies skills an...

HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization 

Gender-specific consequences after HCV eradication are unexplored. MicroRNAs (miRNAs) play a crucial role in the immune response against viral infections. However, few have highlighted miRNA role in sex-biased disease or therapy response. We aim to assess gender differences reflected in the miRNA e...

When to change treatment of acute invasive aspergillosis: an expert viewpoint 

Invasive aspergillosis (IA) is an acute infection affecting patients who are immunocompromised, as a result of receiving chemotherapy for malignancy, or immunosuppressant agents for transplantation or autoimmune disease. Whilst criteria exist to define the probability of infection for clinical tria...

Evolución de la mortalidad atribuible al alcohol en España según edad, sexo, causa de muerte y tipo de bebedor (2001-2017) 

[ES] En España no hay estimaciones recientes de la mortalidad atribuible a alcohol con datos de consumo de alcohol españoles. El objetivo es estimarla y conocer la evolución entre 2001 y 2017 en personas ≥15 años, según sexo, edad, periodo, causa de muerte y tipo de bebedor. Se utilizó el enfoque c...

Metodología utilizada para estimar la mortalidad atribuible a alcohol en España, 2001-2017 

[ES] El objetivo es describir y discutir los métodos y asunciones para estimar la mortalidad atribuible a alcohol en España en 2001-2017. Se estimó el nº medio anual de muertes atribuibles a alcohol (MAAs) basándose en 19 grupos de causas de muerte relacionadas con alcohol (18 parcialmente atribuib...