Publication: A 14-year Prospective Study of Human Coronavirus Infections in Hospitalized Children: Comparison With Other Respiratory Viruses
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2020-08
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Lippincott Williams & Wilkins (LWW)
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Background: Human coronaviruses (HCoVs) have been recognized as causative agents of respiratory tract infections.Our aim was to describe HCoV infections in hospitalized children in a prospective surveillance study for 14 years and compare them with other respiratory viruses. Methods: As a part of an ongoing prospective study to identify the etiology of viral respiratory infections in Spain, we performed the analysis of HCoV infections in children hospitalized in a secondary hospital in Madrid, between October 2005 and June 2018. Clinical data of HCoV patients were compared with those infected by rhinovirus, respiratory syncytial virus and influenza. Results: The study population consisted of 5131 hospitalizations for respiratory causes in children. A total of 3901 cases (75.9%) had a positive viral identification and 205 cases (4.1%) were positive for HCoV. Only 41 cases (20%) of HCoV infection were detected as single infections. Episodes of recurrent wheezing were the most common diagnosis, and 112 children (54%) had hypoxia. Clinical data in HCoV cases were similar to those associated with rhinovirus; however, patients with HCoV were younger. Other viruses were associated with hypoxia more frequently than cases with HCoV; high fever was more common in influenza infections and bronchiolitis in respiratory syncytial virus group. Although a slight peak of circulation appears mostly in winter, HCoV has been detected throughout the year as well. Conclusions: HCoV infections represent a small fraction of respiratory infections that require hospitalization in children and their characteristics do not differ greatly from other respiratory viral infections.
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Hospitalization Adolescent Age Distribution Betacoronavirus Bronchiolitis, Viral COVID-19 Child Child, Preschool Coronavirus Infections Coronavirus NL63, Human Coronavirus OC43, Human Female Fever Humans Hypoxia Infant Infant, Newborn Influenza, Human Male Middle East Respiratory Syndrome Coronavirus Pandemics Picornaviridae Infections Pneumonia, Viral Prospective Studies Respiratory Sounds Respiratory Syncytial Virus Infections Respiratory Tract Infections Rhinovirus Severe acute respiratory syndrome-related coronavirus SARS-CoV-2 Seasons Severe Acute Respiratory Syndrome Severity of Illness Index Spain
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Pediatr Infect Dis J. 2020 Aug;39(8):653-657.