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dc.contributor.authorCoronel Lopez, Raquel 
dc.contributor.authorBernabeu-Zornoza, Adela 
dc.contributor.authorPalmer, Charlotte 
dc.contributor.authorGonzález-Sastre, Rosa 
dc.contributor.authorRosca, Andreea 
dc.contributor.authorMateos-Martínez, Patricia 
dc.contributor.authorLópez-Alonso, Victoria 
dc.contributor.authorListe-Noya, Isabel
dc.identifier.citationInt J Mol Sci. 2023 Aug 19;24(16):12964.es_ES
dc.description.abstractNumerous studies have focused on the pathophysiological role of amyloid precursor protein (APP) because the proteolytic processing of APP to β-amyloid (Aβ) peptide is a central event in Alzheimer's disease (AD). However, many authors consider that alterations in the physiological functions of APP are likely to play a key role in AD. Previous studies in our laboratory revealed that APP plays an important role in the differentiation of human neural stem cells (hNSCs), favoring glial differentiation (gliogenesis) and preventing their differentiation toward a neuronal phenotype (neurogenesis). In the present study, we have evaluated the effects of APP overexpression in hNSCs at a global gene level by a transcriptomic analysis using the massive RNA sequencing (RNA-seq) technology. Specifically, we have focused on differentially expressed genes that are related to neuronal and glial differentiation processes, as well as on groups of differentially expressed genes associated with different signaling pathways, in order to find a possible interaction between them and APP. Our data indicate a differential expression in genes related to Notch, Wnt, PI3K-AKT, and JAK-STAT signaling, among others. Knowledge of APP biological functions, as well as the possible signaling pathways that could be related to this protein, are essential to advance our understanding of AD.es_ES
dc.description.sponsorshipThis research was supported by a grant from the Spanish Ministry of Science and Innovation (RTI2018-101663-B-100) and grant number PID2021-126715OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. R.C. was supported by FPU predoctoral contract from Universidad de Alcalá (FPU-UAH).es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.subjectAmyloid precursor proteines_ES
dc.subjectNeural stem cellses_ES
dc.subjectSignaling pathwayses_ES
dc.subjectRNA sequencinges_ES
dc.subject.meshNeural Stem Cells es_ES
dc.subject.meshAlzheimer Disease es_ES
dc.subject.meshHumans es_ES
dc.subject.meshAmyloid beta-Protein Precursor es_ES
dc.subject.meshPhosphatidylinositol 3-Kinases es_ES
dc.subject.meshNeurogenesis es_ES
dc.subject.meshSignal Transduction es_ES
dc.titleAmyloid Precursor Protein (APP) Regulates Gliogenesis and Neurogenesis of Human Neural Stem Cells by Several Signaling Pathwayses_ES
dc.typeresearch articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Ciencia e Innovación (España) es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) es_ES
dc.contributor.funderUniversity of Alcalá (España) es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.rights.accessRightsopen accesses_ES

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