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dc.contributor.authorObando, Ignacio
dc.contributor.authorMuñoz-Almagro, Carmen
dc.contributor.authorArroyo, Luis A
dc.contributor.authorTarrago Asensio, David 
dc.contributor.authorSanchez-Tatay, David
dc.contributor.authorMoreno-Perez, David
dc.contributor.authorDhillon, Sahar S
dc.contributor.authorEsteva, Cristina
dc.contributor.authorHernandez-Bou, Susanna
dc.contributor.authorGarcia-Garcia, Juan J
dc.contributor.authorHausdorff, William P
dc.contributor.authorBrueggemann, Angela B
dc.identifier.citationEmerg Infect Dis. 2008 Sep;14(9):1390-7.es_ES
dc.description.abstractPediatric parapneumonic empyema (PPE) has been increasing in several countries including Spain. Streptococcus pneumoniae is a major PPE pathogen; however, antimicrobial pretreatment before pleural fluid (PF) sampling frequently results in negative diagnostic cultures, thus greatly underestimating the contribution of pneumococci, especially pneumococci susceptible to antimicrobial agents, to PPE. The study aim was to identify the serotypes and genotypes that cause PPE by using molecular diagnostics and relate these data to disease incidence and severity. A total of 208 children with PPE were prospectively enrolled; blood and PF samples were collected. Pneumococci were detected in 79% of culture-positive and 84% of culture-negative samples. All pneumococci were genotyped by multilocus sequence typing. Serotypes were determined for 111 PPE cases; 48% were serotype 1, of 3 major genotypes previously circulating in Spain. Variance in patient complication rates was statistically significant by serotype. The recent PPE increase is principally due to nonvaccine serotypes, especially the highly invasive serotype 1.es_ES
dc.description.sponsorshipThis research was supported by Fondo de Investigaciones Sanitarias (PI050924 and CP05/00068), the Spanish Pneumococcal Infection Study Network (G03-103) and the Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008) of the Spanish Ministry of Health, and GlaxoSmithKline Biologicals. L.A.A. was supported by Fundacion CajaSol and D.S.-T. was supported by Consejería de Salud from the Andalusian Government.es_ES
dc.publisherCenters for Disease Control and Prevention (CDC) es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshEmpyema, Pleural es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfant es_ES
dc.subject.meshMolecular Epidemiology es_ES
dc.subject.meshPneumonia, Pneumococcal es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshRetrospective Studies es_ES
dc.subject.meshSpain es_ES
dc.subject.meshStreptococcus pneumoniae es_ES
dc.titlePediatric parapneumonic empyema, Spaines_ES
dc.typeresearch articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderRETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España) es_ES
dc.contributor.funderGlaxoSmithKline es_ES
dc.contributor.funderFundación CajaSoles_ES
dc.contributor.funderRegional Government of Andalusia (España) es_ES
dc.identifier.journalEmerging infectious diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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