Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15908
Título
Suppressor of fused associates with dissemination patterns in patients with glioma
Autor(es)
Fecha de publicación
2022-08
Cita
Front Oncol. 2022 Aug 24;12:923681.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Gliomas are the most common brain tumors, which present poor prognosis, due, in part, to tumor cell migration and infiltration into distant brain areas. However, the underlying mechanisms causing such effects are unknown. Hedgehog (HH)-Gli axis is one of the signaling pathways involved, with a high number of molecular mediators. In this study, we investigated the association between HH-Gli intermediates and clinical parameters. We found that high levels of SuFu are associated with high dissemination patterns in patients with glioma. Therefore, we analyzed SuFu expression data in three glioma cohorts of surgical samples (N =1,759) and modified its expression in Glioblastoma Cancer Stem Cells (GB CSC) in vitro models. Our data reveal that SuFu overexpression increases cancer stemness properties together with a migratory phenotype. This work identifies SuFu as a new molecular player in glioma cell migration and a promising target to develop blocking agents to decrease GB dissemination.
Palabras clave
SuFu = suppressor of fused | Brain tumors | Glioblastoma | Glioma | Hedgehog glioma-associated oncogene 1 (GLI1) | Migration
Versión en línea
DOI
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- Supplementary material