Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15862
Título
Concurrent Assessment of Phthalates/HEXAMOLL® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies
Autor(es)
Rosolen, Valentina | Giordani, Elisa | Mariuz, Marika | Parpinel, Maria | Ronfani, Luca | Vecchi Brumatti, Liza | Bin, Maura | Calamandrei, Gemma | Mustieles, Vicente | Gilles, Liese | Govarts, Eva | Baken, Kirsten | Rodriguez Martin, Laura | Schoeters, Greet | Sepai, Ovnair | Sovcikova, Eva | Fabelova, Lucia | Šidlovská, Miroslava | Kolena, Branislav | Kold Jensen, Tina | Frederiksen, Hanne | Kolossa-Gehring, Marike | Lange, Rosa | Apel, Petra | Castaño, Argelia ISCIII | Esteban-Lopez, Marta ISCIII | Jacobs, Griet | Voorspoels, Stefan | Jurdáková, Helena | Górová, Renáta | Barbone, Fabio
Fecha de publicación
2022-09-16
Cita
Toxics. 2022 Sep 16;10(9):538.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL® DINCH) on children's neurodevelopment is limited. The aim of the present research is to evaluate the association between phthalate/HEXAMOLL® DINCH exposure and child neurodevelopment in three European cohorts involved in HBM4EU Aligned Studies. Participating subjects were school-aged children belonging to the Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, and PCB cohort, Slovakia. In each cohort, children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score (FSIQ) of the Wechsler Intelligence Scale of Children test using three different editions. The children's urine samples, collected for one point in time concurrently with the neurodevelopmental evaluation, were analyzed for several phthalates/HEXAMOLL® DINCH biomarkers. The relation between phthalates/HEXAMOLL® DINCH and FSIQ was explored by applying separate multiple linear regressions in each cohort. The means and standard deviations of FSIQ were 109 ± 11 (NAC-II), 98 ± 12 (OCC), and 81 ± 15 (PCB cohort). In NAC-II, direct associations between FSIQ and DEHP's biomarkers were found: 5OH-MEHP+5oxo-MEHP (β = 2.56; 95% CI 0.58-4.55; N = 270), 5OH-MEHP+5cx-MEPP (β = 2.48; 95% CI 0.47-4.49; N = 270) and 5OH-MEHP (β = 2.58; 95% CI 0.65-4.51; N = 270). On the contrary, in the OCC the relation between DEHP's biomarkers and FSIQ tended to be inverse but imprecise (p-value ≥ 0.10). No associations were found in the PCB cohort. FSIQ was not associated with HEXAMOLL® DINCH in any cohort. In conclusion, these results do not provide evidence of an association between concurrent phthalate/DINCHHEXAMOLLR DINCH exposure and IQ in children.
Palabras clave
Full-Scale Intelligence Quotient | HBM4EU | HEXAMOLL® DINCH | WISC | Aligned studies | Children | Environmental contaminants | Human biomonitoring | Neurodevelopment | Phthalates
Versión en línea
DOI
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- supplementary material