Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14920
Título
Strong Cellular Immune Response, but Not Humoral, against SARS-CoV-2 in Oncohematological Patients with Autologous Stem Cell Transplantation after Natural Infection
Autor(es)
Vigon-Hernandez, Lorena ISCIII | Sánchez-Tornero, Adrián | Rodríguez-Mora, Sara ISCIII | García-Pérez, Javier ISCIII | Corona de Lapuerta, Magdalena | Pérez-Lamas, Lucía | Casado-Fernández, Guiomar ISCIII | Moreno, Gemma | Torres, Montserrat ISCIII | Mateos, Elena ISCIII | Murciano-Antón, María Aránzazu | Alcamí, José ISCIII | Perez-Olmeda, Mayte ISCIII | López-Jiménez, Javier | García-Gutiérrez, Valentín | Coiras, Mayte ISCIII | Multidisciplinary Group Of Study Of Covid-Mgs-Covid
Fecha de publicación
2022-04-11
Cita
J Clin Med. 2022 Apr 11;11(8):2137.
Idioma
Inglés
Tipo de documento
research article
Resumen
Oncohematological patients show a low immune response against SARS-CoV-2, both to natural infection and after vaccination. Most studies are focused on the analysis of the humoral response; therefore, the information available about the cellular immune response is limited. In this study, we analyzed the humoral and cellular immune responses in nine individuals who received chemotherapy for their oncohematological diseases, as well as consolidation with autologous stem cell transplantation (ASCT), after being naturally infected with SARS-CoV-2. All individuals had asymptomatic or mild COVID-19 and were not vaccinated against SARS-CoV-2. These results were compared with matched healthy individuals who also had mild COVID-19. The humoral response against SARS-CoV-2 was not detected in 6 of 9 oncohematological individuals prior to ASCT. The levels of antibodies and their neutralization capacity decreased after ASCT. Conversely, an enhanced cytotoxic activity against SARS-CoV-2-infected cells was observed after chemotherapy plus ASCT, mostly based on high levels of NK, NKT, and CD8+TCRγδ+ cell populations that were able to produce IFNγ and TNFα. These results highlight the importance of performing analyses not only to evaluate the levels of IgGs against SARS-CoV-2, but also to determine the quality of the cellular immune response developed during the immune reconstitution after ASCT.
Palabras clave
COVID-19 | SARS-CoV-2 neutralizing antibodies | Autologous transplantation | Cellular cytotoxicity | Oncohematological disease
Versión en línea
DOI
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