Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14756
Título
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Autor(es)
Benschop, Kimberley S M | Broberg, Eeva K | Hodcroft, Emma | Schmitz, Dennis | Albert, Jan | Baicus, Anda | Bailly, Jean-Luc | Baldvinsdottir, Gudrun | Berginc, Natasa | Blomqvist, Soile | Böttcher, Sindy | Brytting, Mia | Bujaki, Erika | Cabrerizo, Maria ISCIII | Celma, Cristina | Cinek, Ondrej | Claas, Eric C J | Cremer, Jeroen | Dean, Jonathan | Dembinski, Jennifer L | Demchyshyna, Iryna | Diedrich, Sabine | Dudman, Susanne | Dunning, Jake | Dyrdak, Robert | Emmanouil, Mary | Farkas, Agnes | De Gascun, Cillian | Fournier, Guillaume | Georgieva, Irina | Gonzalez-Sanz, Ruben ISCIII | van Hooydonk-Elving, Jolanda | Jääskeläinen, Anne J | Jancauskaite, Ruta | Keeren, Kathrin | Fischer, Thea K | Krokstad, Sidsel | Nikolaeva-Glomb, Lubomira | Novakova, Ludmila | Midgley, Sofie E | Mirand, Audrey | Molenkamp, Richard | Morley, Ursula | Mossong, Joël | Muralyte, Svajune | Murk, Jean-Luc | Nguyen, Trung | Nordbø, Svein A | Österback, Riikka | Pas, Suzan | Pellegrinelli, Laura | Pogka, Vassiliki | Prochazka, Birgit | Rainetova, Petra | Van Ranst, Marc | Roorda, Lieuwe | Schuffenecker, Isabelle | Schuurman, Rob | Stoyanova, Asya | Templeton, Kate | Verweij, Jaco J | Voulgari-Kokota, Androniki | Vuorinen, Tytti | Wollants, Elke | Wolthers, Katja C | Zakikhany, Katherina | Neher, Richard | Harvala, Heli | Simmonds, Peter
Fecha de publicación
2021-06
Cita
Emerg Infect Dis. 2021 Jun;27(6):1616-1626.
Idioma
Inglés
Tipo de documento
journal article
Resumen
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.
Palabras clave
Europe | European Non-Polio Enterovirus Network | Molecular epidemiology | Nextstrain; echovirus 30 | Enterovirus | Epidemiological monitoring | Evolutionary trajectory | Genetic recombination | Meningitis/encephalitis | Neurological manifestations | Viruses | Whole-genome sequencing
MESH
Echovirus Infections | Enterovirus Infections | Enterovirus B, Human | Europe | Genotype | Humans | Molecular Epidemiology | Phylogeny | Sequence Analysis, DNA
Versión en línea
DOI
Aparece en las colecciones