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dc.contributor.authorPeláez-García de la Rasilla, Teresa
dc.contributor.authorGonzalez-Jimenez, Irene 
dc.contributor.authorFernández-Arroyo, Andrea
dc.contributor.authorRoldán, Alejandra 
dc.contributor.authorCarretero-Ares, Jose Luis
dc.contributor.authorGarcía-Clemente, Marta
dc.contributor.authorTelenti-Asensio, Mauricio
dc.contributor.authorGarcía-Prieto, Emilio
dc.contributor.authorMartínez-Suarez, Mar
dc.contributor.authorVázquez-Valdés, Fernando
dc.contributor.authorMelón-García, Santiago
dc.contributor.authorCaminal-Montero, Luis
dc.contributor.authorFernández-Simón, Inmaculada
dc.contributor.authorMellado, Emilia 
dc.contributor.authorSánchez-Núñez, María Luisa
dc.contributor.authorHUCAPA Group
dc.date.accessioned2022-05-24T09:12:44Z
dc.date.available2022-05-24T09:12:44Z
dc.date.issued2022-03-19
dc.identifier.citationJ Fungi (Basel). 2022 Mar 19;8(3):316.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14479
dc.description.abstractMost cases of invasive aspergillosis are caused by Aspergillus fumigatus, whose conidia are ubiquitous in the environment. Additionally, in indoor environments, such as houses or hospitals, conidia are frequently detected too. Hospital-acquired aspergillosis is usually associated with airborne fungal contamination of the hospital air, especially after building construction events. A. fumigatus strain typing can fulfill many needs both in clinical settings and otherwise. The high incidence of aspergillosis in COVID patients from our hospital, made us wonder if they were hospital-acquired aspergillosis. The purpose of this study was to evaluate whether the hospital environment was the source of aspergillosis infection in CAPA patients, admitted to the Hospital Universitario Central de Asturias, during the first and second wave of the COVID-19 pandemic, or whether it was community-acquired aspergillosis before admission. During 2020, sixty-nine A. fumigatus strains were collected for this study: 59 were clinical isolates from 28 COVID-19 patients, and 10 strains were environmentally isolated from seven hospital rooms and intensive care units. A diagnosis of pulmonary aspergillosis was based on the ECCM/ISHAM criteria. Strains were genotyped by PCR amplification and sequencing of a panel of four hypervariable tandem repeats within exons of surface protein coding genes (TRESPERG). A total of seven genotypes among the 10 environmental strains and 28 genotypes among the 59 clinical strains were identified. Genotyping revealed that only one environmental A. fumigatus from UCI 5 (box 54) isolated in October (30 October 2020) and one A. fumigatus isolated from a COVID-19 patient admitted in Pneumology (Room 532-B) in November (24 November 2020) had the same genotype, but there was a significant difference in time and location. There was also no relationship in time and location between similar A. fumigatus genotypes of patients. The global A. fumigatus, environmental and clinical isolates, showed a wide diversity of genotypes. To our knowledge, this is the first study monitoring and genotyping A. fumigatus isolates obtained from hospital air and COVID-19 patients, admitted with aspergillosis, during one year. Our work shows that patients do not acquire A. fumigatus in the hospital. This proves that COVID-associated aspergillosis in our hospital is not a nosocomial infection, but supports the hypothesis of "community aspergillosis" acquisition outside the hospital, having the home environment (pandemic period at home) as the main suspected focus of infection.es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCAPA community-acquiredes_ES
dc.subjectCAPA hospital-acquiredes_ES
dc.subjectCOVID-19es_ES
dc.subjectAspergillosises_ES
dc.titleCOVID-19 Associated Pulmonary Aspergillosis (CAPA): Hospital or Home Environment as a Source of Life-Threatening Aspergillus fumigatus Infection?es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID35330318es_ES
dc.format.volume8es_ES
dc.format.number3es_ES
dc.format.page316es_ES
dc.identifier.doi10.3390/jof8030316es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2309-608Xes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jof8030316es_ES
dc.identifier.journalJournal of fungi (Basel, Switzerland)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional