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dc.contributor.authorMol, Hans G J
dc.contributor.authorElbers, Ingrid
dc.contributor.authorPälmke, Claudia
dc.contributor.authorBury, Daniel
dc.contributor.authorGöen, Thomas
dc.contributor.authorEsteban-Lopez, Marta 
dc.contributor.authorNübler, Stefanie
dc.contributor.authorVaccher, Vincent
dc.contributor.authorAntignac, Jean-Philippe
dc.contributor.authorDvořáková, Darina
dc.contributor.authorHajšlová, Jana
dc.contributor.authorSakhi, Amrit Kaur
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorVorkamp, Katrin
dc.contributor.authorCastaño, Argelia 
dc.contributor.authorKoch, Holger M
dc.identifier.citationToxics. 2022 Jan 26;10(2):57.es_ES
dc.description.abstractA quality assurance/quality control program was implemented in the framework of the EU project HBM4EU to assess and improve the comparability of biomarker analysis and to build a network of competent laboratories. Four rounds of proficiency tests were organized for 15 phthalate and two DINCH urinary biomarkers (0.2-138 ng/mL) over a period of 18 months, with the involvement of 28 laboratories. A substantial improvement in performance was observed after the first round in particular, and by the end of the program, an average satisfactory performance rate of 90% was achieved. The interlaboratory reproducibility as derived from the participants' results varied for the various biomarkers and rounds, with an average of 24% for the biomarkers of eight single-isomer phthalates (e.g., DnBP and DEHP) and 43% for the more challenging biomarkers of the mixed-isomer phthalates (DiNP, DiDP) and DINCH. When the reproducibility was based only on the laboratories that consistently achieved a satisfactory performance, this improved to 17% and 26%, respectively, clearly demonstrating the success of the QA/QC efforts. The program thus aided in building capacity and the establishment of a network of competent laboratories able to generate comparable and accurate HBM data for phthalate and DINCH biomarkers in 14 EU countries. In addition, global comparability was ensured by including external expert laboratories.es_ES
dc.description.sponsorshipThis study was part of the HBM4EU project receiving funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032. Co-funding was received from the Dutch Ministry of Agriculture, Nature and Food Quality (project KB 37-002-014-001/002).es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.subjectExternal quality assurance scheme (EQUAS)es_ES
dc.subjectHuman biomonitoring (HBM)es_ES
dc.subjectInterlaboratory comparison investigation (ICI)es_ES
dc.subjectProficiency testinges_ES
dc.titleProficiency and Interlaboratory Variability in the Determination of Phthalate and DINCH Biomarkers in Human Urine: Results from the HBM4EU Projectes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea. H2020 es_ES
dc.contributor.funderMinistry of Agriculture, Nature and Food Quality (Países Bajos)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Sanidad Ambientales_ES
dc.rights.accessRightsopen accesses_ES

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