Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/14394
Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19
Lozano-Rodríguez, Roberto | Valentín-Quiroga, Jaime | Avendaño-Ortiz, José | Martín-Quirós, Alejandro | Pascual-Iglesias, Alejandro | Terrón-Arcos, Verónica | Montalbán-Hernández, Karla | Casalvilla-Dueñas, José Carlos | Bergón-Gutiérrez, Marta | Alcamí, José ISCIII | Garcia-Perez, Javier ISCIII | Cascajero, Almudena ISCIII | García-Garrido, Miguel Ángel | Balzo-Castillo, Álvaro Del | Peinado, María | Gómez, Laura | Llorente-Fernández, Irene | Martín-Miguel, Gema | Herrero-Benito, Carmen | Benito, José Miguel | Rallón, Norma | Vela-Olmo, Carmen | López-Morejón, Lissette | Cubillos-Zapata, Carolina | Aguirre, Luis A | Fresno, Carlos Del | López-Collazo, Eduardo
Cell Rep. 2022 Jan 11;38(2):110235.
We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak after one vaccine shot in individuals recovered from COVID-19, while a second dose is needed in naive subjects, although the latter group shows reduced levels all along the analyzed period. Despite how the neutralization capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mirrors this behavior early after vaccination, both groups show comparable neutralizing antibodies and S-specific B cell levels late post-vaccination. When studying cellular responses, naive individuals exhibit higher SARS-CoV-2-specific cytokine production, CD4+ T cell activation, and proliferation than do individuals recovered from COVID-19, with patent inverse correlations between humoral and cellular variables early post-vaccination. However, almost 8 months post-vaccination, SARS-CoV-2-specific responses are comparable between both groups. Our data indicate that a previous history of COVID-19 differentially determines the functional T and B cell-mediated responses to BNT162b2 vaccination over time.
BNT162b2 vaccine | COVID-19-recovered | SARS-CoV-2 | Antigen-specific T cell | Cellular responses | Cytokine production | Humoral responses | Memory B cell | Proliferation | Spike
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