dc.contributor.author | Fernández-Delgado, Lucía | |
dc.contributor.author | Càmara, Jordi | |
dc.contributor.author | González-Díaz, Aida | |
dc.contributor.author | Grau, Immaculada | |
dc.contributor.author | Shoji, Hisashi | |
dc.contributor.author | Tubau, Fe | |
dc.contributor.author | Martí, Sara | |
dc.contributor.author | Domínguez, Mª Ángeles | |
dc.contributor.author | Carratalà, Jordi | |
dc.contributor.author | Yuste, Jose Enrique | |
dc.contributor.author | Ardanuy, Carmen | |
dc.date.accessioned | 2022-05-09T07:19:15Z | |
dc.date.available | 2022-05-09T07:19:15Z | |
dc.date.issued | 2021-10-28 | |
dc.identifier.citation | Microorganisms. 2021 Oct 28;9(11):2245. | es_ES |
dc.identifier.issn | 2076-2607 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14315 | |
dc.description.abstract | We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011-2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017-2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Fondo de Investigaciones Sanitarias de la Seguridad Social [PI (PI14/00627; PI18/00339, and by CIBER de Enfermedades Respiratorias, CIBERES; [CB06/06/0037], run by the Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Financial support was also provided by the European Regional Development Fund/European Social Fund (ERDF/ESF, “Investing in your future”). We thank CERCA Programme/Generalitat de Catalunya for institutional support. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Streptococcus pneumoniae | es_ES |
dc.subject | Antimicrobial resistance | es_ES |
dc.subject | Pneumococcal conjugate vaccines (PCVs) | es_ES |
dc.subject | Pneumonia | es_ES |
dc.subject | Serotype | es_ES |
dc.title | Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 34835371 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 2245 | es_ES |
dc.identifier.doi | 10.3390/microorganisms9112245 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Government of Catalonia (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/microorganisms9112245 | es_ES |
dc.identifier.journal | Microorganisms | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MSC//CB06%2F06%2F0037/ES/Enfermedades respiratorias 37/ | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2014). Modalidad proyectos en salud. (2014)/PI14/00627 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18 - Proyectos de investigacion en salud (AES 2018). Modalidad proyectos en salud. (2018)/PI18/00339 | es_ES |