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dc.contributor.authorPenela-Sánchez, Daniel
dc.contributor.authorGonzález-de-Audicana, Jon
dc.contributor.authorArmero, Georgina
dc.contributor.authorHenares, Desiree
dc.contributor.authorEsteva, Cristina
dc.contributor.authorde-Sevilla, Mariona-Fernández
dc.contributor.authorRicart, Silvia
dc.contributor.authorJordan, Iolanda
dc.contributor.authorBrotons, Pedro
dc.contributor.authorCabrerizo, Maria 
dc.contributor.authorMuñoz-Almagro, Carmen
dc.contributor.authorLaunes, Cristian
dc.identifier.citationViruses. 2021;13(10):2059.es_ES
dc.description.abstractInfection by rhinovirus (RV) and enterovirus (EV) in children ranges from asymptomatic infection to severe lower respiratory tract infection (LRTI). This cohort study evaluates the clinical impact of RV/EV species, alone or in codetection with other viruses, in young children with severe LRTI. Seventy-one patients aged less than 5 years and admitted to the Paediatric Intensive Care Unit (PICU) of a reference children's hospital with RV or EV (RV/EV) LRTI were prospectively included from 1/2018 to 3/2020. A commercial PCR assay for multiple respiratory pathogens was performed in respiratory specimens. In 22/71, RV/EV + respiratory syncytial virus (RSV) was found, and 18/71 had RV/EV + multiple viral detections. Patients with single RV/EV detection required invasive mechanical ventilation (IMV) as frequently as those with RSV codetection, whereas none of those with multiple viral codetections required IMV. Species were determined in 60 samples, 58 being RV. No EV-A, EV-C, or EV-D68 were detected. RV-B and EV-B were only found in patients with other respiratory virus codetections. There were not any associations between RV/EV species and severity outcomes. To conclude, RV/EV detection alone was observed in young children with severe disease, while multiple viral codetections may result in reduced clinical severity. Differences in pathogenicity between RV and EV species could not be drawn.es_ES
dc.description.sponsorshipThis project is supported by the Spanish National Health Institute Carlos III (Grant id. PI17/349). DH received a grant for predoctoral training in research into Health by the Spanish National Health Institute Carlos III (project number: FI17/00248). DH also received a grant from Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) for a research stay. The funders have not influenced the design or analysis, nor have they had any role in preparing the manuscript.es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectIntensive care unitses_ES
dc.subjectLower respiratory tract infectiones_ES
dc.titleLower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infectionses_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderSociedad Española de Enfermedades Infecciosas y Microbiología Clínicaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/null/Contratos Predoctorales de Formación en investigación en salud (PFIS) (2017)/FI17/00248es_ES

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Atribución 4.0 Internacional
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