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dc.contributor.authorVaccaro, Lucianna
dc.contributor.authorGomes, Thiago Santos
dc.contributor.authorIzquierdo, Fernando
dc.contributor.authorMagnet, Angela
dc.contributor.authorLlorens Berzosa, Sergio
dc.contributor.authorOllero, Dolores
dc.contributor.authorSalso, Santiago
dc.contributor.authorAlhambra, Almudena
dc.contributor.authorGómez, Carmen
dc.contributor.authorLópez Cano, María
dc.contributor.authorPelaz, Carmen 
dc.contributor.authorBellido Samaniego, Beatriz 
dc.contributor.authorDel Aguila, Carmen
dc.contributor.authorFenoy, Soledad
dc.contributor.authorHurtado-Marcos, Carolina
dc.identifier.citationFront Microbiol. 2021;12:707187.es_ES
dc.description.abstractL. feeleii is one of the most frequent Legionella species isolated from natural pools of the central region of Spain. This study aimed to evaluate its ecology and to identify this Legionella species as a respiratory pathogen. A PCR assay for detecting the L. feeleii mip gene was developed to identify it in clinical and environmental samples. Culture and PCR were performed in environmental samples from four drinking water treatment plants (DWTPs). Free L. feeleii was only detected in raw water samples (3.4%), while L. feeleii as an Acanthamoeba endosymbiont was found in 30.7% of raw water, 11.5% of decanter biofilm, and 32% of finished water samples. Therefore, Acanthamoeba spp. plays an essential role in the multiplication, persistence, and spread of Legionella species in the environment. The first case of Legionnaires' disease caused by L. feeleii in Spain is described in this study. The case was diagnosed in an older woman through PCR and sequencing from urine and sputum samples. A respiratory infection could be linked with health care procedures, and the patient presented several risk factors (age, insulin-dependent diabetes, and heart disease). The detection of non-L. pneumophila, such as L. feeleii, is a factor that must be considered when establishing or reviewing measures for the control and prevention of legionellosis.es_ES
dc.description.sponsorshipThis work was supported by Instituto de Salud Carlos III (PI12/02725) (PI17/01670) (Co-funded by European Regional Development Fund/European Social Fund “A way to make Europe”/“Investing in your future”); and Fundación Universitaria San Pablo CEU (USPCEU-PC07/2013 and USP-PC07/2014). LV was supported by Universidad San Pablo CEU/Spain (FPI Grants). TG was supported by CAPES/Brazil (BEX 9132/13-9). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherFrontiers Media es_ES
dc.subjectL. feeleiies_ES
dc.subjectLegionnaires’ diseasees_ES
dc.subjectDrinking water treatment plantses_ES
dc.subjectMolecular diagnosises_ES
dc.titleLegionella feeleii: Ubiquitous Pathogen in the Environment and Causative Agent of Pneumoniaes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)es_ES
dc.contributor.funderFundación Universitaria San Pablo CEUes_ES
dc.contributor.funderCEU San Pablo Universityes_ES
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)es_ES
dc.identifier.journalFrontiers in Microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI17 - Proyectos de investigacion en salud (AES 2017). Modalidad proyectos en salud. (2017)/PI17/01670es_ES

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Atribución 4.0 Internacional
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