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dc.contributor.authorLlamosas-Falcón, Laura
dc.contributor.authorSánchez-Díaz, Germán
dc.contributor.authorGallego, Elisa
dc.contributor.authorVillaverde-Hueso, Ana 
dc.contributor.authorArias-Merino, Greta 
dc.contributor.authorPosada de la Paz, Manuel 
dc.contributor.authorAlonso-Ferreira, Veronica 
dc.date.accessioned2022-04-20T09:28:46Z
dc.date.available2022-04-20T09:28:46Z
dc.date.issued2022-03-08
dc.identifier.citationSci Rep. 2022;12(1):3750.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14126
dc.description.abstractMuscular dystrophies (MD) are a group of rare hereditary degenerative diseases. Our aim was to analyze the mortality pattern in Spain from 1981 to 2016 to assess the temporal trend and discern possible geographic differences using population-based data. Annual deaths related to MD were obtained from the National Statistics Institute with codes 359.1 of the ICD-9 (1981-1998) and G71.0 of the ICD-10 (1999-2016). Age-adjusted mortality rates were calculated and changes in mortality trends were identified. The standardized mortality ratios (SMR) and their respective 95% confidence intervals were calculated by district for 1999-2016. Smoothed SMRs and posterior probability were also assessed and then mapped to look for patterns or geographic distribution. All rates were expressed per 1,000,000 inhabitants. A total of 2,512 deaths (73.8% men) were identified. The age-adjusted mortality rates varied from 0.63 (95% CI 0.40-0.95) in 1981 to 1.51 (95% CI 1.17-1.93) in 2016. MD mortality showed a significant increase of 8.81% per year (95% CI 5.0-12.7) from 1981 to 1990, remaining stable afterwards. Areas with risk of death higher than expected for Spain as a whole were identified, not showing a specific regional pattern. In conclusion, the rising trend in MD mortality might be attributable to advanced improvements in diagnostic techniques leading to a rise in prevalence. Further research on the districts with the highest mortality would be necessary.es_ES
dc.description.sponsorshipThis research was funded by Instituto de Salud Carlos III, Spanish Strategy Action for Health (AESI), project PI14CIII/00067, TPY 1238/15.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleA population-based study of mortality due to muscular dystrophies across a 36-year period in Spaines_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID35260676es_ES
dc.format.volume12es_ES
dc.format.number1es_ES
dc.format.page3750es_ES
dc.identifier.doi10.1038/s41598-022-07814-zes_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-022-07814-zes_ES
dc.identifier.journalScientific Reportses_ES
dc.repisalud.centroISCIII::Instituto de Investigación de Enfermedades Rarases_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI14CIII/00067es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/TPY1238/15es_ES


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