Publication: Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice
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2021-06-29
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Rodriguez-Izquierdo, Ignacio
Ceña-Diez, Rafael
Serramia, Maria Jesús
Rodriguez-Fernández, Rosa
Martinez, Isidoro ISCIII 
Muñoz-Fernández, Mariángeles
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Multidisciplinary Digital Publishing Institute (MDPI)
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Abstract
The respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV, envelope glycoproteins G and F, and cell surface heparan sulfate proteoglycans (HSPG) is required for binding and entry into the host cells. A G2-S16 polyanionic carbosilane dendrimer was identified as a possible RSV inhibitor. We speculated that the G2-S16 dendrimer adheres to the host cell-surface HSPG, acts through binding to HS receptors, and prevents further RSV infection. The G2-S16 dendrimer was non-toxic when applied intranasally to Balb/c mice, and interestingly enough, this G2-S16 dendrimer inhibits 85% RSV. Therefore, our G2-S16 dendrimer could be a candidate for developing a new possible therapy against RSV infection.
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Polymers (Basel). 2021;13(13):2141.