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dc.contributor.authorGómez-Talavera, Sandra
dc.contributor.authorFernandez-Jimenez, Rodrigo 
dc.contributor.authorFuster, Valentin 
dc.contributor.authorNothnagel, Nils D
dc.contributor.authorKouwenhoven, Marc
dc.contributor.authorClemence, Matthew
dc.contributor.authorGarcía-Lunar, Inés
dc.contributor.authorGómez-Rubín, María C
dc.contributor.authorNavarro, Felipe
dc.contributor.authorPérez-Asenjo, Braulio
dc.contributor.authorFernández-Friera, Leticia
dc.contributor.authorCalero, María J
dc.contributor.authorOrejas, Miguel
dc.contributor.authorCabrera, José Ángel
dc.contributor.authorDesco, Manuel
dc.contributor.authorPizarro, Gonzalo 
dc.contributor.authorIbáñez, Borja 
dc.contributor.authorSánchez-González, Javier
dc.contributor.authorNothnagel, Nils D.
dc.contributor.authorGómez-Rubín, María C.
dc.contributor.authorCalero, María J.
dc.contributor.authorCabrera, José Ángel
dc.identifier.citationJACC Cardiovasc Imaging. 2021 Sep;14(9):1742-1754es_ES
dc.description.abstractThis study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold. CMR is the reference tool for cardiac imaging but is time-consuming. A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female). Left ventricular (LV) mass, volumes, and LV and right ventricular (RV) ejection fraction (LVEF, RVEF) were assessed by 3D ESSOS and 2D cine CMR. LGE (% LV) was assessed using 3D and 2D sequences. Three-dimensional and LGE acquisitions lasted 24 and 22 s, respectively. Three-dimensional and LGE images were of good quality and allowed quantification in all cases. Mean LVEF by 3D and 2D CMR were 51 ± 12% and 52 ± 12%, respectively, with excellent intermethod agreement (intraclass correlation coefficient [ICC]: 0.96; 95% confidence interval [CI]: 0.94 to 0.97) and insignificant bias. Mean RVEF 3D and 2D CMR were 60.4 ± 5.4% and 59.7 ± 5.2%, respectively, with acceptable intermethod agreement (ICC: 0.73; 95% CI: 0.63 to 0.81) and insignificant bias. Both 2D and 3D LGE showed excellent agreement, and intraobserver and interobserver agreement were excellent for 3D LGE. ESSOS single breath-hold 3D CMR allows accurate assessment of heart anatomy and function. Combining ESSOS with 3D LGE allows complete cardiac examination in <1 min of acquisition time. This protocol expands the indication for CMR, reduces costs, and increases patient comfort.es_ES
dc.description.sponsorshipFunding included Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund (ERDF) Grants DTS17/00136 to Dr. Ibáñez and PI19/01704 to Dr. Fernandez-Jimenez; Spanish Society of Cardiology Translational Research Grant 2016 to Dr. Ibáñez; European Research Council ERC-CoG 819775-MATRIX to Dr. Ibáñez; Comunidad de Madrid S2017/BMD-3867-RENIM-CM to Drs. Desco and Ibáñez; and Ministerio de Ciencia e Innovación (MICINN) RETOS2019-107332RB-I00 to Dr. Ibáñez. Dr. Fernandez-Jimenez received funding from the European Union Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Hrant Agreement No. 707642. The CNIC is supported by the ISCIII, the MICINN, and the Pro CNIC Foundation. Drs. Fernandez-Jimenez, Nothnagel, Fuster, Ibáñez, and Javier Sánchez-González are inventors of a joint patent (Philips/CNIC) for the new cine imaging method here described and validated/protected under the IP #2014P00960EP. Drs. Nothnagel, Kouwenhoven, Clemence, and Javier Sánchez-González are Philips employees. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.es_ES
dc.publisherElsevier es_ES
dc.subject.meshContrast Media es_ES
dc.subject.meshMagnetic Resonance Imaging, Cine es_ES
dc.subject.meshAged es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGadolinium es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImaging, Three-Dimensionales_ES
dc.subject.meshMagnetic Resonance Spectroscopy es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPredictive Value of Tests es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshReproducibility of Results es_ES
dc.titleClinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC) es_ES
dc.contributor.funderFundación ProCNIC es_ES
dc.contributor.funderComunidad de Madrid (España) es_ES
dc.identifier.journalJACC. Cardiovascular imaginges_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación: Imagen y Salud Cardiovasculares_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/PI19/0 1704es_ES
dc.rights.accessRightsopen accesses_ES

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