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dc.contributor.authorAmate, Jose Maria 
dc.contributor.authorLopez-Cuadrado, Teresa 
dc.contributor.authorAlmendro, Nuria 
dc.contributor.authorBouza, Carmen 
dc.contributor.authorSaz-Parkinson, Z
dc.contributor.authorRivas-Ruiz, R
dc.contributor.authorGonzalez-Canudas, J
dc.identifier.citationInt J Clin Pract. 2015 Mar;69(3):292-304.es_ES
dc.description.abstractObjective: Our review analyses the studies that have specifically compared the association iDPP4/metformin with glimepiride/metformin, both in second line pharmacotherapy of type 2 diabetes mellitus (DM2). Methods: Systematic literature review with a meta-analysis of clinical trials comparing glimepiride with any iDPP4, both used together with metformin as a second line treatment of DM2. The effectiveness variables used were as follows: %HbA1c variation, fasting plasma glucose variation, patients achieving the therapeutic objective of HbA1c <7%, treatment dropouts due to lack of effectiveness and rescue treatments needed. The safety variables included were as follows: weight variation at the end of treatment; presentation of any type of adverse event; presentation of serious adverse events; patients who experienced any type of hypoglycaemia; patients who experienced severe hypoglycaemia; treatments suspended due to adverse effects; and deaths for any reason. Results: Four studies met the inclusion criteria. The group treated with glimepiride showed better results in all effectiveness variables. Regarding safety variables, the main differences observed were in the greater number of cases with hypoglycaemia in the group treated with glimepiride, and the serious adverse events or treatment discontinuations due to these which occurred in slightly over 2% more cases in this group compared to the iDPP4 group. The remaining adverse events, including mortality, did not show any differences between both groups. The variation in the weight difference between groups (2.1 kg) is not considered clinically relevant. Conclusions: A greater effectiveness is seen in the glimepiride/metformin association, which should not be diminished by slight differences in adverse effects, with absence of severe hypoglycaemia in over 98% of patients under treatment. The association of glimepiride/metformin, both due to cost as well as effectiveness and safety, may be the preferential treatment for most DM2 patients, and it offers a potential advantage in refractory hyperglycemic populations, tolerant to treatment.es_ES
dc.publisherWiley es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshBlood Glucose es_ES
dc.subject.meshDiabetes Mellitus, Type 2 es_ES
dc.subject.meshDipeptidyl Peptidase 4 es_ES
dc.subject.meshDrug Therapy, Combination es_ES
dc.subject.meshHumans es_ES
dc.subject.meshHypoglycemic Agents es_ES
dc.subject.meshMetformin es_ES
dc.subject.meshSulfonylurea Compounds es_ES
dc.subject.meshTreatment Outcome es_ES
dc.titleEffectiveness and safety of glimepiride and iDPP4, associated with metformin in second line pharmacotherapy of type 2 diabetes mellitus: systematic review and meta-analysises_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.journalInternational Journal of Clinical Practicees_ES
dc.repisalud.centroISCIII::Agencia de Evaluación de Tecnologías Sanitariases_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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Atribución-NoComercial 4.0 Internacional
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