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dc.contributor.authorWilton, Joana 
dc.contributor.authorAcebo, Paloma 
dc.contributor.authorHerranz, Cristina 
dc.contributor.authorGomez-Lopez, Alicia 
dc.contributor.authorAmblar, Monica
dc.identifier.citationFront Genet. 2015 Apr 7;6:126.es_ES
dc.description.abstractStreptococcus pneumoniae is a prominent human pathogen responsible for many severe diseases and the leading cause of childhood mortality worldwide. The pneumococcus is remarkably adept at colonizing and infecting different niches in the human body, and its adaptation to dynamic host environment is a central aspect of its pathogenesis. In the last decade, increasing findings have evidenced small RNAs (sRNAs) as vital regulators in a number of important processes in bacteria. In S. pneumoniae, a small antisense RNA was first discovered in the pMV158 plasmid as a copy number regulator. More recently, genome-wide screens revealed that the pneumococcal genome also encodes multiple sRNAs, many of which have important roles in virulence while some are implicated in competence control. The knowledge of the sRNA-mediated regulation in pneumococcus remains very limited, and future research is needed for better understanding of functions and mechanisms. Here, we provide a comprehensive summary of the current knowledge on sRNAs from S. pneumoniae, focusing mainly on the trans-encoded sRNAs.es_ES
dc.description.sponsorshipThis work was supported by the Fondo de Investigación Sanitaria (FIS; PI11/00656) and CIBER Enfermedades Respiratorias (an initiative of the Instituto de Salud Carlos III). PA was the recipient of a contract funded by the FIS project PI11/00656 and JW was the recipient of grant from the Inov Contacto C18 program, attributed by the Agência para o Investimento e Comércio Externo de Portugal with Portuguese and European funds.es_ES
dc.publisherFrontiers Media es_ES
dc.subjectStreptococcus pneumoniaees_ES
dc.subjectSmall non-coding RNAses_ES
dc.subjectVirulence regulationes_ES
dc.titleSmall regulatory RNAs in Streptococcus pneumoniae: discovery and biological functionses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderAgência para o Investimento e Comércio Externo de Portugal es_ES
dc.identifier.journalFrontiers in Geneticses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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