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dc.contributor.authorMéndez-Echevarría, Ana
dc.contributor.authorCaminoa, María Belén
dc.contributor.authorDel Rosal, Teresa
dc.contributor.authorCasas Flecha, Inmaculada 
dc.contributor.authorPozo Sanchez, Francisco 
dc.contributor.authorPascual-Pascual, Samuel Ignacio
dc.contributor.authorGarcía-Romero, Mar
dc.contributor.authorCámara, Carmen
dc.contributor.authorCalvo, Cristina
dc.date.accessioned2022-03-28T10:39:31Z
dc.date.available2022-03-28T10:39:31Z
dc.date.issued2021-05
dc.identifier.citationViruses. 2021 May 9;13(5):867.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13854
dc.description.abstractBackground: The impact of respiratory virus infection in patients diagnosed with ataxia-telangiectasia (A-T) has not been well studied. Methods: A prospective case control study was performed at a National Reference Unit for Primary Immunodeficiency in Spain (from November 2018 to July 2019), including patients younger than 20 years. Symptom questionnaires and nasopharyngeal swabs from multiple respiratory viruses' polymerase chain reaction were collected monthly, and between visits in case of symptoms. Results: Twenty-two individuals were included (11 patients; 11 controls); 164 samples were obtained (81 patients; 84 controls). Patients presented respiratory symptoms more frequently compared with controls (26.5% vs. 3.5%; p < 0.01). Viral detection was observed in 23 (27.3%) episodes in patients and in 15 (17.8%) episodes in controls (p = 0.1). Rhinovirus was the most frequent virus in patients and controls (60% and 53.3%, respectively). Episodes with positive viral detection had associated symptoms in 54% of patients and 18% of controls (p = 0.07). However, patients with A-T presented a similar rate of symptoms during episodes with positive and negative viral detection (26% vs. 27%). The median points given for each questionnaire during symptomatic episodes with negative viral detection were 13/23 points, and during symptomatic positive detection, 7.5/23 points (p = 0.1). In the control group, all but two were asymptomatic during positive viral episodes (score: 2/23 and 3/23 points). Symptomatic episodes, with either positive or negative viral detection, were associated with lower IgA and higher IgM titers and higher CD8+ counts (p < 0.05), particularly when these episodes were moderate/severe. Conclusions: Patients with A-T more frequently present symptomatic viral infections than controls, especially those with lower IgA and higher IgM titers and higher CD8+ counts.es_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III, and Fondos FEDER of the EU, Grant No. PI18CIII/00372 (Fondo de Investigaciones Sanitarias—Spanish Health Research Fund (ISCIII)).es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectViruseses_ES
dc.subjectRhinoviruses_ES
dc.subjectPrimary immunodeficiency diseaseses_ES
dc.subjectAtaxia-telangiectasiaes_ES
dc.subjectRespiratory tract infectionses_ES
dc.titleThe Role of Respiratory Viruses in Children with Ataxia-Telangiectasiaes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID34065066es_ES
dc.format.volume13es_ES
dc.format.number5es_ES
dc.identifier.doi10.3390/v13050867es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderEuropean Regional Development Fund es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1999-4915es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/v13050867es_ES
dc.identifier.journalViruseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI18CIII/00372es_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional