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dc.contributor.authorBalestrino, Roberta
dc.contributor.authorHurtado-Gonzalez, Carlos Alberto
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorRadicati, Fabiana Giada
dc.contributor.authorChaudhuri, K Ray
dc.contributor.authorRodriguez-Blazquez, Carmen 
dc.contributor.authorMartinez-Martin, Pablo 
dc.contributor.authorPDCS European Study Group
dc.identifier.citationNPJ Parkinsons Dis. 2019 Nov 27;5:26.es_ES
dc.description.abstractThis study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). Frequency of symptoms was determined by the scores of items (present if >0). Using ROC analysis and Youden method, MDS-UPDRS motor subtypes were projected on the PDCS to achieve a comparable classification based on the PDCS scores. The same method was used to estimate severity levels from other measures in the study. The association between the PDCS and QoL (PDQ-39) was analyzed by correlation and multiple linear regression. The sample consisted of 776 PD patients. We found that the frequency of PD manifestations with PDCS and MDS-UPDRS were overlapping, the average difference between scales being 5.5% only. Using the MDS-UPDRS subtyping, 215 patients (27.7%) were assigned as Tremor Dominant (TD), 60 (7.7%) Indeterminate, and 501 (64.6%) Postural Instability and Gait Difficulty (PIGD) in this cohort. With this classification as criterion, the analogous PDCS-based ratio provided these cut-off values: TD subtype, ≥1.06; Indeterminate, <1.06 but >0.65; and PIGD, <0.65. The agreement between the two scales on this classification was substantial (87.6%; kappa = 0.69). PDCS total score cut-offs for PD severity were: 23/24 for mild/moderate and 41/42 for moderate/severe. Moderate to high correlations (r = 0.35-0.80) between PDCS and PDQ-39 were obtained, and the four PDCS domains showed a significant independent influence on QoL. The conclusions are: (1) the PDCS assessed the frequency of PD symptoms analogous to the MDS-UPDRS; (2) motor subtypes and severity levels can be determined with the PDCS; (3) a significant association between PDCS and QoL scores exists.es_ES
dc.description.sponsorshipThe authors thank the European Parkinson’s Disease Association for leading the My PD Journey initiative that includes the development and funding of the PDCS and the validation studies. F. Radicati also received a grant from the European Parkinson’s Disease Association in her role as Coordinator of this study.es_ES
dc.publisherNature Publishing Group es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectParkinson’s Disease Composite Scale (PDCS)es_ES
dc.subjectParkinson diseasees_ES
dc.titleApplications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS)es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderEuropean Parkinson’s Disease Associationes_ES
dc.identifier.journalNPJ Parkinson's Diseasees_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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