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dc.contributor.authorKlingelhoefer, Lisa
dc.contributor.authorChaudhuri, Kallol R
dc.contributor.authorKamm, Christoph
dc.contributor.authorMartínez-Martín, Pablo 
dc.contributor.authorBhatia, Kailash
dc.contributor.authorSauerbier, Anna
dc.contributor.authorKaiser, Maximilian
dc.contributor.authorRodriguez-Blazquez, Carmen 
dc.contributor.authorBalint, Bettina
dc.contributor.authorUntucht, Robert
dc.contributor.authorHall, Lynsey J
dc.contributor.authorMildenstein, Lauritz
dc.contributor.authorWienecke, Miriam
dc.contributor.authorMartino, Davide
dc.contributor.authorGregor, Olaf
dc.contributor.authorStorch, Alexander
dc.contributor.authorReichmann, Heinz
dc.date.accessioned2022-03-23T11:32:43Z
dc.date.available2022-03-23T11:32:43Z
dc.date.issued2019-10
dc.identifier.citationAnn Clin Transl Neurol. 2019 Oct;6(10):2054-2065.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13804
dc.description.abstractObjetive: To develop and validate a novel 14-item self-completed questionnaire (in English and German) enquiring about the presence of non-motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter study. Methods: The Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest) covers seven domains including sleep, autonomic symptoms, fatigue, emotional well-being, stigma, activities of daily living, sensory symptoms. The feasibility and clinimetric attributes were analyzed. Results: Data from 194 patients with CD (65.6% female, mean age 58.96 ± 12.17 years, duration of disease 11.95 ± 9.40 years) and 102 age- and sex-matched healthy controls (66.7% female, mean age 55.67 ± 17.62 years) were collected from centres in Germany and the UK. The median total NMS score in CD patients was 5 (interquartile range 3-7), significantly higher than in healthy controls with 1 (interquartile range 0.75-2.25) (P < 0.001, Mann-Whitney U-test). Evidence for intercorrelation and convergent validity is shown by moderate to high correlations of total DNMSQuest score with motor symptom severity (TWSTRS: rs  = 0.61), clinical global impression (rs  = 0.40), and health-related quality of life measures: CDQ-24 (rs  = 0.74), EQ-5D index (rs  = -0.59), and scale (rs  = -0.49) (all P < 0.001). Data quality and acceptability was very satisfactory. Interpretation: The DNMSQuest, a patient self-completed questionnaire for NMS assessment in CD patients, appears robust, reproducible, and valid in clinical practice showing a tangible impact of NMS on quality of life in CD. As there is no specific, comprehensive, validated tool to assess the burden of NMS in dystonia, the DNMSQuest can bridge this gap and could easily be integrated into clinical practice.es_ES
dc.language.isoenges_ES
dc.publisherWiley es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPsychometrics es_ES
dc.subject.meshReproducibility of Results es_ES
dc.subject.meshSurveys and Questionnaires es_ES
dc.subject.meshTorticollis es_ES
dc.titleValidation of a self-completed Dystonia Non-Motor Symptoms Questionnairees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31560179es_ES
dc.format.volume6es_ES
dc.format.number10es_ES
dc.format.page2054-2065es_ES
dc.identifier.doi10.1002/acn3.50900es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2328-9503es_ES
dc.relation.publisherversionhttps://doi.org/10.1002/acn3.50900es_ES
dc.identifier.journalAnnals of Clinical and Translational Neurologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional